Advertisement
J. Lipid Res.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tang, G. W.
Right arrow Articles by Russell, R. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tang, G. W.
Right arrow Articles by Russell, R. M.
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Journal of Lipid Research, Vol 31, 175-182, Copyright © 1990 by Lipid Research, Inc.


ARTICLES

13-cis-retinoic acid is an endogenous compound in human serum

GW Tang and RM Russell
USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111.

The occurrence of 13-cis-retinoic acid as an endogenous component in human serum has been confirmed by cochromatography with standards in both normal-phase and reverse-phase high-performance liquid chromatographic (HPLC) system, by the lambda max of its UV spectrum recorded simultaneously with the HPLC run, and by chromatography of its methyl derivative. The method using solid-phase extraction followed by a gradient reverse-phase HPLC procedure with an internal standard and sensitive UV detector, provides an efficient and sensitive technique for the separation and quantification of serum 13-cis- and all-trans- retinoic acid. Serum levels of 13-cis- and all-trans-retinoic acid in 26 fasting volunteers ranged from 1.0 to 2.2 ng/ml (mean +/- SEM = 1.4 +/- 0.3 ng/ml) and from 1.1 to 1.9 ng/ml (mean +/- SEM = 1.4 +/- 0.2 ng/ml), respectively. The levels determined by a liquid-liquid double- phase extraction method were 90% higher in both 13-cis- and all- trans- retinoic acid than those from a solid-phase extraction. Human small intestine can isomerize all-trans-retinoic acid. 13-cis-Retinoic acid is the predominant cis isomer after incubation of intestinal mucosa homogenates with all-trans-retinoic acid. Moreover, the concentration of retinoic acid in serum is related to diet in that the level of total retinoic acid was 36% higher (n = 10) 2 h after a nonstandard breakfast than in fasting subjects.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
J. Lipid Res.Home page
S. H. Gieng, J. Raila, and F. J. Rosales
Accumulation of retinol in the liver after prolonged hyporetinolemia in the vitamin A-sufficient rat
J. Lipid Res., April 1, 2005; 46(4): 641 - 649.
[Abstract] [Full Text] [PDF]


Home page
Cancer Epidemiol. Biomarkers Prev.Home page
R. L. Sedjo, J. Ranger-Moore, J. Foote, N. E. Craft, D. S. Alberts, M.-J. Xu, and A. R. Giuliano
Circulating Endogenous Retinoic Acid Concentrations among Participants Enrolled in a Randomized Placebo-Controlled Clinical Trial of Retinyl Palmitate
Cancer Epidemiol. Biomarkers Prev., November 1, 2004; 13(11): 1687 - 1692.
[Abstract] [Full Text] [PDF]


Home page
J. Nutr.Home page
T. van Vliet, E. Boelsma, A. J. de Vries, and H. van den Berg
Retinoic Acid Metabolites in Plasma Are Higher after Intake of Liver Paste Compared with a Vitamin A Supplement in Women
J. Nutr., December 1, 2001; 131(12): 3197 - 3203.
[Abstract] [Full Text] [PDF]


Home page
J. Nutr.Home page
K.-J. Yeum, S.-H. Ahn, S. A. Rupp de Paiva, Y. C. Lee-Kim, N. I. Krinsky, and R. M. Russell
Correlation between Carotenoid Concentrations in Serum and Normal Breast Adipose Tissue of Women with Benign Breast Tumor or Breast Cancer
J. Nutr., November 1, 1998; 128(11): 1920 - 1926.
[Abstract] [Full Text]


Home page
Pharmacol. Rev.Home page
T. C. Roos, F. K. Jugert, H. F. Merk, and D. R. Bickers
Retinoid Metabolism in the Skin
Pharmacol. Rev., June 1, 1998; 50(2): 315 - 333.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. Takase, K. Tanaka, K. Suruga, M. Kitagawa, M. Igarashi, and T. Goda
Dietary fatty acids are possible key determinants of cellular retinol-binding protein II gene expression
Am J Physiol Gastrointest Liver Physiol, April 1, 1998; 274(4): G626 - G632.
[Abstract] [Full Text] [PDF]


Home page
Drug Metab. Dispos.Home page
H. Chen and M. R. Juchau
Biotransformation of 13-cis- and 9-cis-Retinoic Acid to All-trans-Retinoic Acid in Rat Conceptal Homogenates. Evidence for Catalysis by a Conceptal Isomerase
Drug Metab. Dispos., March 1, 1998; 26(3): 222 - 228.
[Abstract] [Full Text]


Home page
Arch DermatolHome page
L. Y. Matsuoka, J. Wortsman, G. Tang, R. M. Russell, L. Parker, R. Gelfand, and R. G. Mehta
Are Endogenous Retinoids Involved in the Pathogenesis of Acne?
Arch Dermatol, July 1, 1991; 127(7): 1072 - 1073.
[Abstract] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 1990 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement