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Journal of Lipid Research, Vol 31, 307-314, Copyright © 1990 by Lipid Research, Inc.

ARTICLES

Identification of metabolites from peroxisomal beta-oxidation of prostaglandins

U Diczfalusy and SE Alexson
Department of Clinical Chemistry I, Huddinge University Hospital, Sweden.

We have recently shown that isolated rat liver peroxisomes can chain- shorten prostaglandin F2 alpha and prostaglandin E2 to tetranor- metabolites. In the present report dinor-metabolites of these two prostaglandins were also identified, suggesting that the peroxisomal chain-shortening reaction of prostaglandins is a beta-oxidation reaction. Furthermore, an intermediate containing an extra double bond was isolated from incubates of prostaglandin F2 alpha with peroxisomes. This intermediate was tentatively assigned the structure 2,3- dehydroprostaglandin F2 alpha. Prostaglandin E1 and a major circulating prostaglandin F2 alpha metabolite were also metabolized to chain- shortened products by peroxisomes. The accumulation of the 2,3-dehydro- metabolite and the dinor-metabolites suggest that the peroxisomal beta- oxidation sequence is not tightly coupled, in contrast to mitochondrial fatty acid oxidation.
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