J. Lipid Res. Neurobiology of Lipids (ISSN1683-5506)
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shillabeer, G.
Right arrow Articles by Lau, D. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shillabeer, G.
Right arrow Articles by Lau, D. C.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Journal of Lipid Research, Vol 31, 623-631, Copyright © 1990 by Lipid Research, Inc.

ARTICLES

Hepatic and adipose tissue lipogenic enzyme mRNA levels are suppressed by high fat diets in the rat

G Shillabeer, J Hornford, JM Forden, NC Wong and DC Lau
Department of Medicine, University of Calgary, Alberta, Canada.

Small changes in lipogenic enzyme activity induced by dietary fats of different composition may, over the long term, have significant impact on the development of obesity. We have investigated the effect of high fat diets (45% of calories as fat) on abundance of mRNA encoding fatty acid synthetase (FAS) and glycerophosphate dehydrogenase (GPDH) in male Sprague-Dawley rats. When caloric intake was equal, the relative amount of hepatic FAS mRNA was greater in rats fed a saturated compared to a polyunsaturated fat diet. This difference could not be attributed to diet-induced changes in plasma insulin concentration. However, both fat diets suppressed hepatic FAS mRNA compared to a sucrose diet. Close correlation between FAS specific activity and the relative amount of mRNA suggested that regulation was mainly at a pre-translational level. Adipose tissue FAS mRNA was suppressed by the two fat diets equally while GPDH mRNA was unaffected by dietary composition. Retroperitoneal fat pads were significantly larger in rats fed saturated compared to those fed polyunsaturated fat for 26 weeks. We concluded that dietary saturated fats fail to suppress hepatic de novo lipogenesis as effectively as polyunsaturated fats, which may have implications for the prevention of obesity in humans.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Nutr.Home page
J. A. Vogt, K. B. Ishii-Schrade, P. B. Pencharz, P. J. H. Jones, and T. M. S. Wolever
L-Rhamnose and Lactulose Decrease Serum Triacylglycerols and Their Rates of Synthesis, but Do Not Affect Serum Cholesterol Concentrations in Men
J. Nutr., August 1, 2006; 136(8): 2160 - 2166.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
M. J. Azain
Role of fatty acids in adipocyte growth and development
J Anim Sci, March 1, 2004; 82(3): 916 - 924.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
M. ROSSMEISL, I. SYROVY, F. BAUMRUK, P. FLACHS, P. JANOVSKÁ, and J. KOPECKY
Decreased fatty acid synthesis due to mitochondrial uncoupling in adipose tissue
FASEB J, September 1, 2000; 14(12): 1793 - 1800.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 1990 by the American Society for Biochemistry and Molecular Biology.