HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Friedl, W. Articles by McCarthy, B. J. Search for Related Content PubMed PubMed Citation Articles by Friedl, W. Articles by McCarthy, B. J. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol 31, 659-665, Copyright © 1990 by Lipid Research, Inc.

ARTICLES

Hypervariability in a minisatellite 3' of the apolipoprotein B gene in patients with coronary heart disease compared with normal controls

W Friedl, EH Ludwig, B Paulweber, F Sandhofer and BJ McCarthy
Gladstone Foundation Laboratories for Cardiovascular Research, University of California, San Francisco 94140-0608.

Several recent reports have examined whether there is a correlation between the presence of some minor alleles of the highly polymorphic apolipoprotein B gene and atherosclerosis and premature heart disease. The present study extends this investigation. A high-resolution method was used to study the allele frequencies of a hypervariable minisatellite region close to the apolipoprotein B gene in 110 patients with severe coronary disease and in 117 normal controls. Alleles containing 38, 44, 46, or 48 hypervariable elements showed an association with coronary heart disease. These alleles were also associated with elevated serum levels of total cholesterol and apolipoprotein B among patients and with elevated serum levels of total triglycerides among controls. The hypervariable region showed strong linkage disequilibrium with a polymorphic EcoRI site in exon 29 and was in linkage equilibrium with a polymorphic MspI site in exon 26. Two patients carried a base change at codon 3500 that results in an arginine-to-glutamine substitution; the base change was linked in both instances to the allele with 48 hypervariable elements.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				P. M. Frossard, E. N. Obineche, and G. G. Lestringant Association of an Apolipoprotein B Gene Marker With Essential Hypertension Hypertension, April 1, 1999; 33(4): 1052 - 1056. [Abstract] [Full Text] [PDF]

				B. Vedie, X. Jeunemaitre, J. L. Megnien, I. Myara, H. Trebeden, A. Simon, and N. Moatti Charge Heterogeneity of LDL in Asymptomatic Hypercholesterolemic Men Is Related to Lipid Parameters and Variations in the ApoB and CIII Genes Arterioscler. Thromb. Vasc. Biol., November 1, 1998; 18(11): 1780 - 1789. [Abstract] [Full Text] [PDF]