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Journal of Lipid Research, Vol 31, 1307-1313, Copyright © 1990 by Lipid Research, Inc.
O Ben-Zeev, MH Doolittle, N Singh, CH Chang and MC Schotz
Lipoprotein lipase (LPL) expression was determined in adult rat hippocampus
and compared to enzyme expression in other brain regions. Hippocampus LPL
mRNA levels were at least 2.5-fold higher than those detected in the
cerebral cortex, cerebellum, and remaining brain regions. Enzyme mass and
activity levels in the hippocampus were also increased to a similar degree.
De novo synthesis of LPL in the hippocampus was confirmed by
[35S]methionine-labeling of the tissue and identification of a 57 kDa
protein obtained by immunoprecipitation. Addition of an excess amount of
bovine LPL completely prevented the immunoprecipitation of this protein.
The effect of nutritional modulations on brain LPL activity was determined
after a 12-h fast. While no significant changes were observed in other
regions of the brain, hippocampus LPL activity in fasted rats increased by
60% compared to the fed control group. Simultaneously, fasting reduced
adipose LPL activity by 60%. Intraperitoneal injection of ACTH over a 5-
day period had no effect on hippocampus LPL activity, while adipose LPL
levels increased 2.3-fold and heart LPL levels decreased 1.4-fold. We
conclude that LPL is synthesized, active and regulated in a tissue-
specific manner in the adult rat hippocampus.
ARTICLES
Synthesis and regulation of lipoprotein lipase in the hippocampus
Department of Lipid Research, Veterans Administration, Wadsworth Medical Center, Los Angeles, CA 90073.
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