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Journal of Lipid Research, Vol 31, 1577-1588, Copyright © 1990 by Lipid Research, Inc.
M La Belle and RM Krauss
The neutral carbohydrate content of both the protein (apoB) and lipid
fractions of low density lipoproteins (LDL) from subjects with a
predominance of small, dense LDL (subclass pattern B) was found to be lower
than in subjects with larger LDL (subclass pattern A): 45 +/- 12 versus 64
+/- 13 mg/g apoLDL, and 58 +/- 8 versus 71 +/- 8 mg/g apoLDL (P less than
0.0005 for both). Sialic acid content of LDL lipids, but not apoB, was also
reduced in subclass pattern B. ApoB and glycolipid carbohydrate content of
total LDL and LDL density subfractions declined with increasing LDL density
and decreasing particle diameter. Moreover, in LDL subfractions from
pattern B subjects, carbohydrate content of LDL apoB, but not LDL
glycolipid, was significantly lower in comparison with particles of similar
size from pattern A subjects. Thus, in LDL subclass pattern B, reductions
in LDL carbohydrate content are associated both with reduced concentrations
of larger carbohydrate- enriched LDL subclasses, and with reduced
glycosylation of apoB in all LDL particles. LDL glycolipids may vary with
overall lipid content of LDL particles, but variation in apoB glycosylation
may indicate differences in pathways for LDL production, and reduced apoB
glycosylation may reflect the altered metabolic state responsible for LDL
subclass pattern B.
ARTICLES
Differences in carbohydrate content of low density lipoproteins associated with low density lipoprotein subclass patterns
Donner Laboratory, Univesity of California, Berkeley.
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