|
 |
|
|||||||
|
|||||||||
Journal of Lipid Research, Vol 32, 1539-1570, Copyright © 1991 by Lipid Research, Inc.
G Schmitz and G Muller
This review article attempts to present an overview of the occurrence and
function of lipid storage and secretory organelles: the lamellar bodies.
Morphologically these organelles vary considerably in size (100 nm to 2400
nm); they are surrounded by a membrane and contain multilamellar lipid
membranes. Lamellar bodies may also contain apolipoproteins and lytic
enzymes and have an acidic pH, which confers on them a lysosomal character.
Under normal physiological conditions, the main function of lamellar bodies
is the supply of extracellular domains with specialized lipid components
related to a specialized function. The lamellar bodies of the lung
epithelium are best investigated in their functional and structural
features and are the storage form of the lung surfactant. They provide a
monomolecular lipid film of dipalmitoyl phosphatidylcholine (DPPC) on the
surface of lung alveoli to lower surface tension necessary for optimal gas
exchange and a hydrophobic protective lining against environmental
influences. Additional cells of the respiratory system such as the mucosa
of the human nose and the bronchi contain lamellar bodies. Lamellar bodies
are also found in the gastrointestinal tract, in tongue papillae, oral
epithelium, and mucosa cells of the stomach. The major phospholipid of
lamellar bodies in mucosa cells of the stomach is DPPC, providing a
hydrophobic protective lipid film against the tissue-damaging activities of
gastric juice. The hydrophobic water-protective barrier of the skin, which
consists mainly of neutral lipids, however, also originates from lamellar
bodies secreted by epithelial cells. Lamellar bodies, mainly consisting of
DPPC, also occur in mesodermal cell layers of sliding surfaces to provide
the lubrication of joints, of the peritoneum, pericardium, and pleural
mesothelium. In certain pathological conditions, such as atherosclerosis,
Niemann-Pick disease, lecithin:cholesterol acyltransferase (LCAT)
deficiency, cholestasis, degeneration of nerves and brain, and regeneration
of nerves and wound healing, lipid-containing lamellar bodies have been
observed in various cells, the function of which still remains to be
elucidated. In early and late lesions of atherosclerotic plaques, lamellar
bodies, consisting of unesterified cholesterol and phospholipids, are
associated with the extracellular matrix of the intima. During regression
of fatty streaks, lamellar bodies are seen intracellularly in macrophages
and smooth muscle cells. Inherited metabolic disorders, such as
Niemann-Pick disease type I and type II, result in the excessive
accumulation of lamellar body-containing cells, for example in bone marrow,
spleen, and lymphoid tissue. Type I is a deficiency in sphingomyelinase and
type II is a defect in intracellular trafficking of lipoprotein-derived
cholesterol.(ABSTRACT TRUNCATED AT 400 WORDS)
REVIEWS
Structure and function of lamellar bodies, lipid-protein complexes involved in storage and secretion of cellular lipids
Institut fur Klinische Chemie und Laboratoriumsmedizin, Universitat Regensburg, Germany.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  B. Payre, P. de Medina, N. Boubekeur, L. Mhamdi, J. Bertrand-Michel, F. Terce, I. Fourquaux, D. Goudouneche, M. Record, M. Poirot, et al. Microsomal antiestrogen-binding site ligands induce growth control and differentiation of human breast cancer cells through the modulation of cholesterol metabolism Mol. Cancer Ther., December 1, 2008; 7(12): 3707 - 3718. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Phillips, E. A. Woodruff III, P. Liang, M. Patten, and K. Broadie Neuronal Loss of Drosophila NPC1a Causes Cholesterol Aggregation and Age-Progressive Neurodegeneration J. Neurosci., June 25, 2008; 28(26): 6569 - 6582. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. V. Andreeva, M. A. Kutuzov, and T. A. Voyno-Yasenetskaya Regulation of surfactant secretion in alveolar type II cells Am J Physiol Lung Cell Mol Physiol, August 1, 2007; 293(2): L259 - L271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Denham, B. J. Conley, F. Olsson, L. Gulluyan, T. J. Cole, and R. Mollard A murine respiratory-inducing niche displays variable efficiency across human and mouse embryonic stem cell species Am J Physiol Lung Cell Mol Physiol, May 1, 2007; 292(5): L1241 - L1247. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ochs Stereological analysis of acute lung injury Eur. Respir. Rev., December 1, 2006; 15(101): 115 - 121. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Cheong, M. Madesh, L. W. Gonzales, M. Zhao, K. Yu, P. L. Ballard, and H. Shuman Functional and Trafficking Defects in ATP Binding Cassette A3 Mutants Associated with Respiratory Distress Syndrome J. Biol. Chem., April 7, 2006; 281(14): 9791 - 9800. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Lajoie, G. Guay, J. W. Dennis, and I. R. Nabi The lipid composition of autophagic vacuoles regulates expression of multilamellar bodies J. Cell Sci., May 1, 2005; 118(9): 1991 - 2003. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Coppens and K. A. Joiner Host but Not Parasite Cholesterol Controls Toxoplasma Cell Entry by Modulating Organelle Discharge Mol. Biol. Cell, September 1, 2003; 14(9): 3804 - 3820. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Niemann, J. Baltes, and H.-P. Elsässer Fluorescence Properties and Staining Behavior of Monodansylpentane, a Structural Homologue of the Lysosomotropic Agent Monodansylcadaverine J. Histochem. Cytochem., February 1, 2001; 49(2): 177 - 186. [Abstract] [Full Text]
|
|
|
|
|
|
S Lusa, T. Blom, E. Eskelinen, E Kuismanen, J. Mansson, K Simons, and E Ikonen Depletion of rafts in late endocytic membranes is controlled by NPC1-dependent recycling of cholesterol to the plasma membrane J. Cell Sci., January 5, 2001; 114(10): 1893 - 1900. [Abstract] [PDF]
|
|
|
|
 |
|
 K. Simons and E. Ikonen How Cells Handle Cholesterol Science, December 1, 2000; 290(5497): 1721 - 1726. [Abstract] [Full Text]
|
|
|
|
|
|
A. Niemann, A. Takatsuki, and H.-P. Elsässer The Lysosomotropic Agent Monodansylcadaverine Also Acts as a Solvent Polarity Probe J. Histochem. Cytochem., February 1, 2000; 48(2): 251 - 258. [Abstract] [Full Text]
|
|
|
|
|
|
M. Hariri, G. Millane, M.-P. Guimond, G. Guay, J. W. Dennis, and I. R. Nabi Biogenesis of Multilamellar Bodies via Autophagy Mol. Biol. Cell, January 1, 2000; 11(1): 255 - 268. [Abstract] [Full Text]
|
|
|
|
 |
|
 B. A. Hills An alternative view of the role(s) of surfactant and the alveolar model J Appl Physiol, November 1, 1999; 87(5): 1567 - 1583. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Lange, J. Ye, and T. L. Steck Circulation of Cholesterol between Lysosomes and the Plasma Membrane J. Biol. Chem., July 24, 1998; 273(30): 18915 - 18922. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-c. Jiang, J. D'Armiento, R. K. Mallampalli, J. Mar, S.-F. Yan, and M. Lin Expression of Plasma Phospholipid Transfer Protein mRNA in Normal and Emphysematous Lungs and Regulation by Hypoxia J. Biol. Chem., June 19, 1998; 273(25): 15714 - 15718. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Vermehren, P. B. Johansen, and H. S. Hansen Absorption and Metabolism of the Absorption Enhancer Didecanoylphosphatidylcholine in Rabbit Nasal Epithelium In Vivo Drug Metab. Dispos., September 1, 1997; 25(9): 1083 - 1088. [Abstract] [Full Text]
|
|
|
|
 |
|
 H. C. Stary, A. B. Chandler, R. E. Dinsmore, V. Fuster, S. Glagov, W. Insull Jr, M. E. Rosenfeld, C. J. Schwartz, W. D. Wagner, and R. W. Wissler A Definition of Advanced Types of Atherosclerotic Lesions and a Histological Classification of Atherosclerosis : A Report From the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association Arterioscler. Thromb. Vasc. Biol., September 1, 1995; 15(9): 1512 - 1531. [Abstract] [Full Text]
|
|
|
|
 |
|
 H. C. Stary, A. B. Chandler, R. E. Dinsmore, V. Fuster, S. Glagov, W. Insull Jr, M. E. Rosenfeld, C. J. Schwartz, W. D. Wagner, and R. W. Wissler A Definition of Advanced Types of Atherosclerotic Lesions and a Histological Classification of Atherosclerosis : A Report From the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association Circulation, September 1, 1995; 92(5): 1355 - 1374. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |