| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Lipid Research, Vol 32, 1741-1753, Copyright © 1991 by Lipid Research, Inc.
ARTICLES |
F Nigon, P Lesnik, M Rouis and MJ Chapman
INSERM Unite 321, Hopital de la Pitie, Paris, France.
The low density lipoproteins (LDL) of human plasma consist of a series of discrete particle subspecies of distinct physicochemical, immunological, and hydrodynamic properties. Such structural differences are intimately linked to the metabolic heterogeneity of circulating LDL in vivo. The current studies were designed to evaluate and compare the interaction of discrete LDL subspecies from normolipidemic subjects with the LDL receptor. Plasma LDL of d 1.019-1.063 g/ml from healthy males were fractionated into 15 subspecies of defined physicochemical characteristics by isopycnic density gradient ultracentrifugation as described earlier (Chapman et al., J. Lipid Res. 1988. 29: 442-458). The major LDL subspecies, LDL-5 to LDL-10, exhibited an overall range in density from 1.0244 to 1.0435 g/ml; individual subspecies increased in density by increments of 0.027 (LDL-5), 0.026 (LDL-6), 0.030 (LDL- 7), 0.031 (LDL-8), 0.035 (LDL-9), and 0.042 g/ml (LDL-10), respectively. Taken together, these subspecies accounted for approximately 70% of the total mass of LDL of d 1.019-1.063 g/ml; their cholesterol: protein ratios decreased from 1.70 to 1.12 and particle size from 275 to 260 A with increase in density. ApoB-100 was the unique protein component in subspecies 5-8, with trace amounts (less than 0.2% of apoLDL) of both apoA-I and apoE in subspecies 9 and 10. The interaction of individual LDL subspecies with the LDL receptor on cultured human U-937 monocyte-like cells was compared by determining receptor binding affinities at 4 degrees C. Scatchard analysis of specific binding curves demonstrated a single class of binding site for each subspecies. The lowest dissociation constants were displayed by LDL subspecies 6 (Kd 5.71 nM), 7 (Kd 5.24 nM) and 8 (Kd 4.67 nM), while subspecies 5, 9, and 10 displayed significantly higher Kd values (8.35, 7.20, and 6.87 nM, respectively). Competitive displacement studies at 4 degrees C, in which unlabeled subspecies from the same gradient series competed for binding with 125I-labeled LDL subspecies, confirmed the relative binding affinities of these subspecies. As the hydrophobic lipid core of LDL undergoes a thermotropic transition at approximately 37 degrees C, which may in turn influence the surface structure of the particle, internalization and degradation studies were performed at 37 degrees C. No effect of temperature was detectable; again, LDL subspecies at each extreme of the density distribution (LDL-5 and LDL- 10) displayed significantly lower binding affinities for the LDL receptor than that from the peak region (LDL-7).(ABSTRACT TRUNCATED AT 400 WORDS)
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  A. M.G. Cali, T. L. Zern, S. E. Taksali, A. M. de Oliveira, S. Dufour, J. D. Otvos, and S. Caprio Intrahepatic Fat Accumulation and Alterations in Lipoprotein Composition in Obese Adolescents: A perfect proatherogenic state Diabetes Care, December 1, 2007; 30(12): 3093 - 3098. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. S. Fisher, P. L. Surdo, S. Pandit, M. Mattu, J. C. Santoro, D. Wisniewski, R. T. Cummings, A. Calzetta, R. M. Cubbon, P. A. Fischer, et al. Effects of pH and Low Density Lipoprotein (LDL) on PCSK9-dependent LDL Receptor Regulation J. Biol. Chem., July 13, 2007; 282(28): 20502 - 20512. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Aspichueta, B. Perez-Agote, S. Perez, B. Ochoa, and O. Fresnedo Impaired response of VLDL lipid and apoB secretion to endotoxin in the fasted rat liver Innate Immunity, June 1, 2006; 12(3): 181 - 191. [Abstract] [PDF]
|
|
|
|
 |
|
 R. J. Wood, J. S. Volek, Y. Liu, N. S. Shachter, J. H. Contois, and M. L. Fernandez Carbohydrate Restriction Alters Lipoprotein Metabolism by Modifying VLDL, LDL, and HDL Subfraction Distribution and Size in Overweight Men J. Nutr., February 1, 2006; 136(2): 384 - 389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kathiresan, J. D. Otvos, L. M. Sullivan, M. J. Keyes, E. J. Schaefer, P. W.F. Wilson, R. B. D'Agostino, R. S. Vasan, and S. J. Robins Increased Small Low-Density Lipoprotein Particle Number: A Prominent Feature of the Metabolic Syndrome in the Framingham Heart Study Circulation, January 3, 2006; 113(1): 20 - 29. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Rufail, H. A. Schenkein, S. E. Barbour, J. G. Tew, and R. van Antwerpen Altered lipoprotein subclass distribution and PAF-AH activity in subjects with generalized aggressive periodontitis J. Lipid Res., December 1, 2005; 46(12): 2752 - 2760. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. L. Ruel, B. Lamarche, J.-F. Mauger, K. O. Badellino, J. S. Cohn, M. Marcil, and P. Couture Effect of Fenofibrate on Plasma Lipoprotein Composition and Kinetics in Patients With Complete Hepatic Lipase Deficiency Arterioscler. Thromb. Vasc. Biol., December 1, 2005; 25(12): 2600 - 2607. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Gazi, E. S. Lourida, T. Filippatos, V. Tsimihodimos, M. Elisaf, and A. D. Tselepis Lipoprotein-Associated Phospholipase A2 Activity Is a Marker of Small, Dense LDL Particles in Human Plasma Clin. Chem., December 1, 2005; 51(12): 2264 - 2273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Krauss Dietary and Genetic Probes of Atherogenic Dyslipidemia Arterioscler. Thromb. Vasc. Biol., November 1, 2005; 25(11): 2265 - 2272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. C. Geiss, S. Bremer, P. H. R. Barrett, C. Otto, and K. G. Parhofer In vivo metabolism of LDL subfractions in patients with heterozygous FH on statin therapy: rebound analysis of LDL subfractions after LDL apheresis J. Lipid Res., August 1, 2004; 45(8): 1459 - 1467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Khovidhunkit, M.-S. Kim, R. A. Memon, J. K. Shigenaga, A. H. Moser, K. R. Feingold, and C. Grunfeld Thematic review series: The Pathogenesis of Atherosclerosis. Effects of infection and inflammation on lipid and lipoprotein metabolism mechanisms and consequences to the host J. Lipid Res., July 1, 2004; 45(7): 1169 - 1196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Bosse, L. Perusse, and M.-C. Vohl Genetics of LDL particle heterogeneity: from genetic epidemiology to DNA-based variations J. Lipid Res., June 1, 2004; 45(6): 1008 - 1026. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. M. Sacks and H. Campos Low-Density Lipoprotein Size and Cardiovascular Disease: A Reappraisal J. Clin. Endocrinol. Metab., October 1, 2003; 88(10): 4525 - 4532. [Full Text] [PDF]
|
|
|
|
|
|
K. Winkler, T. Konrad, S. Fullert, I. Friedrich, R. Destani, M. W. Baumstark, K. Krebs, H. Wieland, and W. Marz Pioglitazone Reduces Atherogenic Dense LDL Particles in Nondiabetic Patients With Arterial Hypertension: A double-blind, placebo-controlled study Diabetes Care, September 1, 2003; 26(9): 2588 - 2594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Guerin, W. Le Goff, E. Frisdal, S. Schneider, D. Milosavljevic, E. Bruckert, and M. J. Chapman Action of Ciprofibrate in Type IIB Hyperlipoproteinemia: Modulation of the Atherogenic Lipoprotein Phenotype and Stimulation of High-Density Lipoprotein-Mediated Cellular Cholesterol Efflux J. Clin. Endocrinol. Metab., August 1, 2003; 88(8): 3738 - 3746. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. C. Felmeden, C. G.C. Spencer, A. D. Blann, D. G. Beevers, and G. Y.H. Lip Low-Density Lipoprotein Subfractions and Cardiovascular Risk in Hypertension: Relationship to Endothelial Dysfunction and Effects of Treatment Hypertension, March 1, 2003; 41(3): 528 - 533. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Wiemer, K. Winkler, M. Baumstark, W. Marz, and J. E. Scherberich Influence of low molecular weight heparin compared to conventional heparin for anticoagulation during haemodialysis on low density lipoprotein subclasses Nephrol. Dial. Transplant., December 1, 2002; 17(12): 2231 - 2238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Winkler, C. Abletshauser, M. M. Hoffmann, I. Friedrich, M. W. Baumstark, H. Wieland, and W. Marz Effect of Fluvastatin Slow-Release on Low Density Lipoprotein (LDL) Subfractions in Patients with Type 2 Diabetes Mellitus: Baseline LDL Profile Determines Specific Mode of Action J. Clin. Endocrinol. Metab., December 1, 2002; 87(12): 5485 - 5490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. Berneis and R. M. Krauss Metabolic origins and clinical significance of LDL heterogeneity J. Lipid Res., September 1, 2002; 43(9): 1363 - 1379. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Sanchez-Quesada, S. Benitez, C. Otal, M. Franco, F. Blanco-Vaca, and J. Ordonez-Llanos Density distribution of electronegative LDL in normolipemic and hyperlipemic subjects J. Lipid Res., May 1, 2002; 43(5): 699 - 705. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kratz, E. Gulbahce, A. von Eckardstein, P. Cullen, A. Cignarella, G. Assmann, and U. Wahrburg Dietary Mono- and Polyunsaturated Fatty Acids Similarly Affect LDL Size in Healthy Men and Women J. Nutr., April 1, 2002; 132(4): 715 - 718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Llorente-Cortes, M. Otero-Vinas, E. Hurt-Camejo, J. Martinez-Gonzalez, and L. Badimon Human Coronary Smooth Muscle Cells Internalize Versican-Modified LDL Through LDL Receptor-Related Protein and LDL Receptors Arterioscler. Thromb. Vasc. Biol., March 1, 2002; 22(3): 387 - 393. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. MERTENS and P. HOLVOET Oxidized LDL and HDL: antagonists in atherothrombosis FASEB J, October 1, 2001; 15(12): 2073 - 2084. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Campos, L. A. Moye, S. P. Glasser, M. J. Stampfer, and F. M. Sacks Low-Density Lipoprotein Size, Pravastatin Treatment, and Coronary Events JAMA, September 26, 2001; 286(12): 1468 - 1474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Marz, H. Scharnagl, C. Abletshauser, M. M. Hoffmann, A. Berg, J. Keul, H. Wieland, and M. W. Baumstark Fluvastatin Lowers Atherogenic Dense Low-Density Lipoproteins in Postmenopausal Women With the Atherogenic Lipoprotein Phenotype Circulation, April 17, 2001; 103(15): 1942 - 1948. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pedersen, M. W. Baumstark, P. Marckmann, H. Gylling, and B. Sandström An olive oil-rich diet results in higher concentrations of LDL cholesterol and a higher number of LDL subfraction particles than rapeseed oil and sunflower oil diets J. Lipid Res., December 1, 2000; 41(12): 1901 - 1911. [Abstract] [Full Text]
|
|
|
|
 |
|
 S M Jones, C P D Harris, J Lloyd, C A Stirling, J P D Reckless, and N J McHugh Lipoproteins and their subfractions in psoriatic arthritis: identification of an atherogenic profile with active joint disease Ann Rheum Dis, November 1, 2000; 59(11): 904 - 909. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. WAKATSUKI, N. IKENOUE, Y. OKATANI, K. SHINOHARA, and T. FUKAYA Lipoprotein Particles in Preeclampsia: Susceptibility to Oxidative Modification Obstet. Gynecol., July 1, 2000; 96(1): 55 - 59. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. M. Schamberger, H. C. Geiss, M. M. Ritter, P. Schwandt, and K. G. Parhofer Influence of LDL apheresis on LDL subtypes in patients with coronary heart disease and severe hyperlipoproteinemia J. Lipid Res., May 1, 2000; 41(5): 727 - 733. [Abstract] [Full Text]
|
|
|
|
|
|
C. J. Packard, T. Demant, J. P. Stewart, D. Bedford, M. J. Caslake, G. Schwertfeger, A. Bedynek, J. Shepherd, and D. Seidel Apolipoprotein B metabolism and the distribution of VLDL and LDL subfractions J. Lipid Res., February 1, 2000; 41(2): 305 - 318. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. A. P. Skyrme-Jones, R. C. O'Brien, M. Luo, and I. T. Meredith Endothelial vasodilator function is related to low-density lipoprotein particle size and low-density lipoprotein vitamin E content in type 1 diabetes J. Am. Coll. Cardiol., February 1, 2000; 35(2): 292 - 299. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lepage, F. Nigon, D. Bonnefont-Rousselot, U. Assogba, S. Goulinet, L. Chancharme, J. Delattre, E. Bruckert, and M. J. Chapman Oxidizability of Atherogenic Low-Density Lipoprotein Subspecies in Severe Familial Hypercholesterolemia: Impact of Long-Term Low-Density Lipoprotein Apheresis Journal of Cardiovascular Pharmacology and Therapeutics, January 1, 2000; 5(2): 87 - 103. [Abstract] [PDF]
|
|
|
|
|
|
M. Guerin, T. S. Lassel, W. Le Goff, M. Farnier, and M. J. Chapman Action of Atorvastatin in Combined Hyperlipidemia : Preferential Reduction of Cholesteryl Ester Transfer From HDL to VLDL1 Particles Arterioscler. Thromb. Vasc. Biol., January 1, 2000; 20(1): 189 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. van Antwerpen, M. La Belle, E. Navratilova, and R. M. Krauss Structural heterogeneity of apoB-containing serum lipoproteins visualized using cryo-electron microscopy J. Lipid Res., October 1, 1999; 40(10): 1827 - 1836. [Abstract] [Full Text]
|
|
|
|
|
|
A. WAKATSUKI, N. IKENOUE, Y. OKATANI, and C. IZUMIYA Lipid Transfer Reactions and Lipid Composition of Low-Density Lipoprotein Particles in Postmenopausal Women Receiving Estrogen Obstet. Gynecol., October 1, 1999; 94(4): 492 - 497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Skoglund-Andersson, R. Tang, M. G. Bond, U. de Faire, A. Hamsten, and F. Karpe LDL Particle Size Distribution Is Associated With Carotid Intima-Media Thickness in Healthy 50-Year-Old Men Arterioscler. Thromb. Vasc. Biol., October 1, 1999; 19(10): 2422 - 2430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. IKENOUE, A. WAKATSUKI, and Y. OKATANI Small Low-Density Lipoprotein Particles in Women With Natural or Surgically Induced Menopause Obstet. Gynecol., April 1, 1999; 93(4): 566 - 570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Chancharme, P. Therond, F. Nigon, S. Lepage, M. Couturier, and M. J. Chapman Cholesteryl Ester Hydroperoxide Lability Is a Key Feature of the Oxidative Susceptibility of Small, Dense LDL Arterioscler. Thromb. Vasc. Biol., March 1, 1999; 19(3): 810 - 820. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Bittolo-Bon and G. Cazzolato Analytical capillary isotachophoresis of total plasma lipoproteins: a new tool to identify atherogenic low density lipoproteins J. Lipid Res., January 1, 1999; 40(1): 170 - 177. [Abstract] [Full Text]
|
|
|
|
|
|
B. Staels, J. Dallongeville, J. Auwerx, K. Schoonjans, E. Leitersdorf, and J.-C. Fruchart Mechanism of Action of Fibrates on Lipid and Lipoprotein Metabolism Circulation, November 10, 1998; 98(19): 2088 - 2093. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Lamarche, A. Tchernof, P. Mauriege, B. Cantin, G. R. Dagenais, P. J. Lupien, and J.-P. Despres Fasting Insulin and Apolipoprotein B Levels and Low-Density Lipoprotein Particle Size as Risk Factors for Ischemic Heart Disease JAMA, June 24, 1998; 279(24): 1955 - 1961. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Chappey, B. Beyssen, E. Foos, F. Ledru, J. L. Guermonprez, J. C. Gaux, and I. Myara Sialic Acid Content of LDL in Coronary Artery Disease: No Evidence of Desialylation in Subjects With Coronary Stenosis and Increased Levels in Subjects With Extensive Atherosclerosis and Acute Myocardial Infarction : Relation Between Desialylation and In Vitro Peroxidation Arterioscler. Thromb. Vasc. Biol., June 1, 1998; 18(6): 876 - 883. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Barbagallo, G. A. Levine, P. J. Blanche, B. Y. Ishida, and R. M. Krauss Influence of ApoE Content on Receptor Binding of Large, Buoyant LDL in Subjects With Different LDL Subclass Phenotypes Arterioscler. Thromb. Vasc. Biol., March 1, 1998; 18(3): 466 - 472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. S. Lassel, M. Guerin, S. Auboiron, M. J. Chapman, and B. Guy-Grand Preferential Cholesteryl Ester Acceptors Among Triglyceride-Rich Lipoproteins During Alimentary Lipemia in Normolipidemic Subjects Arterioscler. Thromb. Vasc. Biol., January 1, 1998; 18(1): 65 - 74. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Packard and J. Shepherd Lipoprotein Heterogeneity and Apolipoprotein B Metabolism Arterioscler. Thromb. Vasc. Biol., December 1, 1997; 17(12): 3542 - 3556. [Abstract] [Full Text]
|
|
|
|
|
|
P. Lesnik, C. Dachet, L. Petit, M. Moreau, S. Griglio, P. Brudi, and M. J. Chapman Impact of a Combination of a Calcium Antagonist and a ß-Blocker on Cell- and Copper-Mediated Oxidation of LDL and on the Accumulation and Efflux of Cholesterol in Human Macrophages and Murine J774 Cells Arterioscler. Thromb. Vasc. Biol., May 1, 1997; 17(5): 979 - 988. [Abstract] [Full Text]
|
|
|
|
|
|
S. Goulinet and M. J. Chapman Plasma LDL and HDL Subspecies Are Heterogenous in Particle Content of Tocopherols and Oxygenated and Hydrocarbon Carotenoids: Relevance to Oxidative Resistance and Atherogenesis Arterioscler. Thromb. Vasc. Biol., April 1, 1997; 17(4): 786 - 796. [Abstract] [Full Text]
|
|
|
|
|
|
B. Lamarche, A. Tchernof, S. Moorjani, B. Cantin, G. R. Dagenais, P. J. Lupien, and J.-P. Despres Small, Dense Low-Density Lipoprotein Particles as a Predictor of the Risk of Ischemic Heart Disease in Men: Prospective Results From the Quebec Cardiovascular Study Circulation, January 7, 1997; 95(1): 69 - 75. [Abstract] [Full Text]
|
|
|
|
|
|
R. Prassl, J. M. Chapman, F. Nigon, M. Sara, S. Eschenburg, C. Betzel, A. Saxena, and P. Laggner Crystallization and Preliminary X-ray Analysis of a Low Density Lipoprotein from Human Plasma J. Biol. Chem., November 15, 1996; 271(46): 28731 - 28733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Guerin, E. Bruckert, P. J. Dolphin, G. Turpin, and M. J. Chapman Fenofibrate Reduces Plasma Cholesteryl Ester Transfer From HDL to VLDL and Normalizes the Atherogenic, Dense LDL Profile in Combined Hyperlipidemia Arterioscler. Thromb. Vasc. Biol., June 1, 1996; 16(6): 763 - 772. [Abstract] [Full Text]
|
|
|
|
|
|
H. Campos, K. S. Arnold, M. E. Balestra, T. L. Innerarity, and R. M. Krauss Differences in Receptor Binding of LDL Subfractions Arterioscler. Thromb. Vasc. Biol., June 1, 1996; 16(6): 794 - 801. [Abstract] [Full Text]
|
|
|
|
|
|
A. Gaw, C. J. Packard, G. M. Lindsay, E. F. Murray, B. A. Griffin, M. J. Caslake, I. Colquhoun, D. J. Wheatley, A. R. Lorimer, and J. Shepherd Effects of Colestipol Alone and in Combination With Simvastatin on Apolipoprotein B Metabolism Arterioscler. Thromb. Vasc. Biol., February 1, 1996; 16(2): 236 - 249. [Abstract] [Full Text]
|
|
|
|
|
|
M. Halle, A. Berg, J. Keul, and M. W. Baumstark Association Between Serum Fibrinogen Concentrations and HDL and LDL Subfraction Phenotypes in Healthy Men Arterioscler. Thromb. Vasc. Biol., January 1, 1996; 16(1): 144 - 148. [Abstract] [Full Text]
|
|
|
|
|
|
D. L. Tribble, P. M. Thiel, J. J.M. van den Berg, and R. M. Krauss Differing {alpha}-Tocopherol Oxidative Lability and Ascorbic Acid Sparing Effects in Buoyant and Dense LDL Arterioscler. Thromb. Vasc. Biol., November 1, 1995; 15(11): 2025 - 2031. [Abstract] [Full Text]
|
|
|
|
|
|
A. D. Tselepis, C. Dentan, S.-A. P. Karabina, M. J. Chapman, and E. Ninio PAF-Degrading Acetylhydrolase Is Preferentially Associated With Dense LDL and VHDL-1 in Human Plasma : Catalytic Characteristics and Relation to the Monocyte-Derived Enzyme Arterioscler. Thromb. Vasc. Biol., October 1, 1995; 15(10): 1764 - 1773. [Abstract] [Full Text]
|
|
|
|
|
|
M. Guerin, P. J. Dolphin, C. Talussot, J. Gardette, F. Berthezene, and M. J. Chapman Pravastatin Modulates Cholesteryl Ester Transfer From HDL to ApoB-Containing Lipoproteins and Lipoprotein Subspecies Profile in Familial Hypercholesterolemia Arterioscler. Thromb. Vasc. Biol., September 1, 1995; 15(9): 1359 - 1368. [Abstract] [Full Text]
|
|
|
|
