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Journal of Lipid Research, Vol 32, 374-379, Copyright © 1991 by Lipid Research, Inc.

ARTICLES

Analysis of two different tandem repetitive elements within the human apolipoprotein B gene

EH Ludwig, K Haubold and BJ McCarthy
Cardiovascular Research Institute, University of California, San Francisco 94140-0608.

A large number of copies of the sequence (dTG-dAC)n, where n is between 10 and 60, exist in the human genome, and many are useful as polymorphic markers. One of these sequences occurs about 3 kilobases 5' of the human apolipoprotein (apo) B gene as seven distinguishable alleles containing from (TG)12 to (TG)18. This repeat is also present in the DNA of other primates. A second alternating purine-pyrimidine sequence with nine dinucleotide repeats and located in intron 4 is not polymorphic. Together with the apoB hypervariable repeat immediately 3' of the gene, the (TG)n sequence will provide a useful haplotype marker capable of distinguishing a large number of human apoB alleles, some of which may be associated with disease states.
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