Journal of Lipid Research, Vol 33, 1619-1628, Copyright © 1992 by Lipid Research, Inc.
Effects of dietary fat on cholesterol movement between tissues in CBA/J and C57BR/cdJ mice
SI Kuan, J Stewart, MK Dowd, L Patterson, J Dupont and RC Seagrave
Department of Chemical Engineering, Iowa State University, Ames 50011.
Differences in dietary fats cause differences in cholesterol metabolism in
mice. CBA/J mice are resistant to diet-induced hypercholesterolemia and
atherosclerosis; they adjust hepatic hydroxymethyl-glutaryl-CoA reductase
activity (HMGR) to maintain homeostasis; C57BR/cdJ mice are susceptible,
but young animals are thought to maintain homeostasis by changing fecal
excretion of sterols. Compartmental modelling of movement of
[4-14C]cholesterol was used to analyze movement of cholesterol between
serum and liver, heart, and carcass in mice fed 40 en% fat, polyunsaturated
to saturated fatty acid ratio (P/S) = 0.24 (US74) or 30 en% fat, P/S = 1
(MOD). Dietary effects were quite pronounced, while strain effects were
more subdued. The C57/cdJ animals appear to regulate the overall
cholesterol balance by reducing synthesis, as do the CBA/J animals, even
though synthesis is not reduced to the same degree as in the CBA/J animals.
Both diet and strain influence the whole-animal turnover rate, with slower
turnover occurring for C57BR/cdJ animals and animals fed the US74 diet.
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