|
 |
|
|||||||
|
|||||||||
Journal of Lipid Research, Vol 33, 369-380, Copyright © 1992 by Lipid Research, Inc.
E Campos, K Nakajima, A Tanaka and RJ Havel
A monoclonal antibody to apolipoprotein (apo) B-100 (JI-H) with unique
binding properties has been used to separate a population of
triglyceride-rich lipoproteins from blood plasma of normotriglyceridemic
individuals and patients with various forms of hypertriglyceridemia. This
antibody fails to recognize an apoE-rich population of very low density
lipoproteins (VLDL) containing apoB-100 as well as all triglyceride-rich
lipoproteins containing apoB-48, but it binds other VLDL that contain apoE
and almost all lipoproteins that contain apoB-100, but no apoE. The unbound
triglyceride-rich lipoproteins separated by ultracentrifugation after
separation from plasma by immunoaffinity chromatography contained 10-13% of
the apoB of triglyceride-rich lipoproteins from three normotriglyceridemic
individuals, 10-29% of that from five patients with endogenous
hypertriglyceridemia, 40-48% of that from three patients with familial
dysbetablipoproteinemia, and 65% of that from a patient with lipoprotein
lipase deficiency. In all cases, the unbound triglyceride- rich
lipoproteins contained more molecules of apoE and cholesteryl esters per
particle than those that were bound to monoclonal antibody JI-H, and they
were generally depleted of C apolipoproteins. These properties resemble
those described for partially catabolized remnants of chylomicrons and
VLDL. The affinity of the unbound lipoproteins for the low density
lipoprotein (LDL) receptor varied widely, and closely resembled that of the
total triglyceride-rich lipoproteins from individual subjects. Our results
demonstrate that remnant-like chylomicrons and a population of remnant-like
VLDL can be isolated and quantified in blood plasma obtained in the
postabsorptive state from normotriglyceridemic and hypertriglyceridemic
individuals alike.
ARTICLES
Properties of an apolipoprotein E-enriched fraction of triglyceride- rich lipoproteins isolated from human blood plasma with a monoclonal antibody to apolipoprotein B-100
Cardiovascular Research Institute, San Francisco, CA.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  J. de Graaf, G. M. van der Vleuten, E. ter Avest, G. M. Dallinga-Thie, and A. F. H. Stalenhoef High Plasma Level of Remnant-Like Particles Cholesterol in Familial Combined Hyperlipidemia J. Clin. Endocrinol. Metab., April 1, 2007; 92(4): 1269 - 1275. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Imke, B. L. Rodriguez, J. S. Grove, J. R. McNamara, C. Waslien, A. R. Katz, B. Willcox, K. Yano, and J. D. Curb Are Remnant-Like Particles Independent Predictors of Coronary Heart Disease Incidence?: The Honolulu Heart Study Arterioscler. Thromb. Vasc. Biol., August 1, 2005; 25(8): 1718 - 1722. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-Q. Lai, S. Demissie, L. A. Cupples, Y. Zhu, X. Adiconis, L. D. Parnell, D. Corella, and J. M. Ordovas Influence of the APOA5 locus on plasma triglyceride, lipoprotein subclasses, and CVD risk in the Framingham Heart Study J. Lipid Res., November 1, 2004; 45(11): 2096 - 2105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. M. Maggi, S. Raselli, L. Grigore, L. Redaelli, S. Fantappie, and A. L. Catapano Lipoprotein Remnants and Endothelial Dysfunction in the Postprandial Phase J. Clin. Endocrinol. Metab., June 1, 2004; 89(6): 2946 - 2950. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Oi, H. Shimokawa, J. Hiroki, T. Uwatoku, K. Abe, Y. Matsumoto, Y. Nakajima, K. Nakajima, S. Takeichi, and A. Takeshita Remnant Lipoproteins from Patients with Sudden Cardiac Death Enhance Coronary Vasospastic Activity Through Upregulation of Rho-Kinase Arterioscler. Thromb. Vasc. Biol., May 1, 2004; 24(5): 918 - 922. [Abstract] [Full Text]
|
|
|
|
|
|
R. B. Heath, F. Karpe, R. W. Milne, G. C. Burdge, S. A. Wootton, and K. N. Frayn Selective partitioning of dietary fatty acids into the VLDL TG pool in the early postprandial period J. Lipid Res., November 1, 2003; 44(11): 2065 - 2072. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Hirowatari, H. Yoshida, H. Kurosawa, K.-i. Doumitu, and N. Tada Measurement of cholesterol of major serum lipoprotein classes by anion-exchange HPLC with perchlorate ion-containing eluent J. Lipid Res., July 1, 2003; 44(7): 1404 - 1412. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Hidaka, M. Tozuka, B. Meyer, K. Yamauchi, M. Sugano, T. Nakabayashi, and T. Katsuyama Characterization of Triglyceride Rich Lipoproteins with Very Light Density by Ultracentrifugation and Agarose Gel Electrophoresis using Triglyceride- and Cholesterol-Staining Ann. Clin. Lab. Sci., April 1, 2003; 33(2): 167 - 178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. B. Twickler, G. M. Dallinga-Thie, F. L. J. Visseren, W. R. de Vries, D. W. Erkelens, and H. P. F. Koppeschaar Induction of Postprandial Inflammatory Response in Adult Onset Growth Hormone Deficiency Is Related to Plasma Remnant-Like Particle-Cholesterol Concentration J. Clin. Endocrinol. Metab., March 1, 2003; 88(3): 1228 - 1233. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Y. Ntanios, Y. Homma, and S. Ushiro A Spread Enriched with Plant Sterol-Esters Lowers Blood Cholesterol and Lipoproteins without Affecting Vitamins A and E in Normal and Hypercholesterolemic Japanese Men and Women J. Nutr., December 1, 2002; 132(12): 3650 - 3655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Somekawa, H. Umeki, K. Kobayashi, S. Tomura, T. Aso, and H. Hamaguchi Effects of Hormone Replacement Therapy and Hepatic Lipase Polymorphism on Serum Lipid Profiles in Postmenopausal Japanese Women J. Clin. Endocrinol. Metab., October 1, 2002; 87(10): 4766 - 4770. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. R. W. de Sauvage Nolting, M. B. Twickler, G. M. Dallinga-Thie, R. J.A. Buirma, B. A. Hutten, J. J.P. Kastelein, and for the Examination of Probands and Relatives in S Elevated Remnant-Like Particles in Heterozygous Familial Hypercholesterolemia and Response to Statin Therapy Circulation, August 13, 2002; 106(7): 788 - 792. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Campos, L. Kotite, P. Blanche, Y. Mitsugi, P. H. Frost, U. Masharani, R. M. Krauss, and R. J. Havel Properties of triglyceride-rich and cholesterol-rich lipoproteins in the remnant-like particle fraction of human blood plasma J. Lipid Res., March 1, 2002; 43(3): 365 - 374. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ai, A. Tanaka, K. Ogita, M. Sekinc, F. Numano, F. Numano, and G. M. Reaven Relationship between plasma insulin concentration and plasma remnant lipoprotein response to an oral fat load in patients with type 2 diabetes J. Am. Coll. Cardiol., November 15, 2001; 38(6): 1628 - 1632. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-S. Kim, F. Abbasi, C. Lamendola, T. McLaughlin, and G. M Reaven Effect of insulin resistance on postprandial elevations of remnant lipoprotein concentrations in postmenopausal women Am. J. Clinical Nutrition, November 1, 2001; 74(5): 592 - 595. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Koutsari, F. Karpe, S. M. Humphreys, K. N. Frayn, and A. E. Hardman Exercise Prevents the Accumulation of Triglyceride-Rich Lipoproteins and Their Remnants Seen When Changing to a High-Carbohydrate Diet Arterioscler. Thromb. Vasc. Biol., September 1, 2001; 21(9): 1520 - 1525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. C. Ooi, M. Cousins, D. S. Ooi, G. Steiner, K. D. Uffelman, K. Nakajima, and I. E. Simo Postprandial Remnant-like Lipoproteins in Hypertriglyceridemia J. Clin. Endocrinol. Metab., July 1, 2001; 86(7): 3134 - 3142. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. W Wilmink, M. B Twickler, J. D. Banga, G. M Dallinga-Thie, H. Eeltink, D.W. Erkelens, T. J Rabelink, and E. S Stroes Effect of statin versus fibrate on postprandial endothelial dysfunction: role of remnant-like particles Cardiovasc Res, June 1, 2001; 50(3): 577 - 582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Karpe, S. Boquist, R. Tang, G. M. Bond, U. de Faire, and A. Hamsten Remnant lipoproteins are related to intima-media thickness of the carotid artery independently of LDL cholesterol and plasma triglycerides J. Lipid Res., January 1, 2001; 42(1): 17 - 21. [Abstract] [Full Text]
|
|
|
|
|
|
T. B. Twickler, H. W. Wilmink, P. C. N. J. Schreuder, M. C. Cabezas, P. S. van Dam, H. P. F. Koppeschaar, D. W. Erkelens, and G. M. Dallinga-Thie Growth Hormone (GH) Treatment Decreases Postprandial Remnant-Like Particle Cholesterol Concentration and Improves Endothelial Function in Adult-Onset GH Deficiency J. Clin. Endocrinol. Metab., December 1, 2000; 85(12): 4683 - 4689. [Abstract] [Full Text]
|
|
|
|
|
|
Th. B. Twickler, G. M. Dallinga-Thie, H. W. de Valk, P. C. N. J. Schreuder, H. Jansen, M. C. Cabezas, and D. W. Erkelens High Dose of Simvastatin Normalizes Postprandial Remnant-Like Particle Response in Patients With Heterozygous Familial Hypercholesterolemia Arterioscler. Thromb. Vasc. Biol., November 1, 2000; 20(11): 2422 - 2427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ai, A. Tanaka, K. Ogita, M. Sekine, F. Numano, F. Numano, and G. M. Reaven Relationship between Hyperinsulinemia and Remnant Lipoprotein Concentrations in Patients with Impaired Glucose Tolerance J. Clin. Endocrinol. Metab., October 1, 2000; 85(10): 3557 - 3560. [Abstract] [Full Text]
|
|
|
|
|
|
R. J. Havel and P. H. Frost The Role of Non-High-Density Lipoprotein-Cholesterol in Evaluation and Treatment of Lipid Disorders J. Clin. Endocrinol. Metab., June 1, 2000; 85(6): 2105 - 2108. [Full Text]
|
|
|
|
|
|
F. Abbasi, T. McLaughlin, C. Lamendola, H. Yeni-Komshian, A. Tanaka, T. Wang, K. Nakajima, and G. M. Reaven Fasting Remnant Lipoprotein Cholesterol and Triglyceride Concentrations Are Elevated in Nondiabetic, Insulin-Resistant, Female Volunteers J. Clin. Endocrinol. Metab., November 1, 1999; 84(11): 3903 - 3906. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. Wang, K. Nakajima, E. T. Leary, G. R. Warnick, J. S. Cohn, P. N. Hopkins, L. L. Wu, D. D. Cilla, J. Zhong, and R. J. Havel Ratio of Remnant-like Particle-Cholesterol to Serum Total Triglycerides Is an Effective Alternative to Ultracentrifugal and Electrophoretic Methods in the Diagnosis of Familial Type III Hyperlipoproteinemia Clin. Chem., November 1, 1999; 45(11): 1981 - 1987. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. van Antwerpen, M. La Belle, E. Navratilova, and R. M. Krauss Structural heterogeneity of apoB-containing serum lipoproteins visualized using cryo-electron microscopy J. Lipid Res., October 1, 1999; 40(10): 1827 - 1836. [Abstract] [Full Text]
|
|
|
|
|
|
J. S. Cohn, C. Marcoux, and J. Davignon Detection, Quantification, and Characterization of Potentially Atherogenic Triglyceride-Rich Remnant Lipoproteins Arterioscler. Thromb. Vasc. Biol., October 1, 1999; 19(10): 2474 - 2486. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. ANDO, T. SANAKA, and H. NIHEI Eicosapentanoic Acid Reduces Plasma Levels of Remnant Lipoproteins and Prevents in Vivo Peroxidation of LDL in Dialysis Patients J. Am. Soc. Nephrol., October 1, 1999; 10(10): 2177 - 2184. [Abstract] [Full Text]
|
|
|
|
|
|
H. Doi, K. Kugiyama, M. Ohgushi, S. Sugiyama, T. Matsumura, Y. Ohta, H. Oka, N. Ogata, A. Hirata, Y. Yamamoto, et al. Membrane Active Lipids in Remnant Lipoproteins Cause Impairment of Endothelium-Dependent Vasorelaxation Arterioscler. Thromb. Vasc. Biol., August 1, 1999; 19(8): 1918 - 1924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kugiyama, H. Doi, K. Takazoe, H. Kawano, H. Soejima, Y. Mizuno, R. Tsunoda, T. Sakamoto, T. Nakano, K. Nakajima, et al. Remnant Lipoprotein Levels in Fasting Serum Predict Coronary Events in Patients With Coronary Artery Disease Circulation, June 8, 1999; 99(22): 2858 - 2860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kugiyama, T. Motoyama, H. Doi, H. Kawano, N. Hirai, H. Soejima, Y. Miyao, K. Takazoe, Y. Moriyama, Y. Mizuno, et al. Improvement of endothelial vasomotor dysfunction by treatment with alpha-tocopherol in patients with high remnant lipoproteins levels J. Am. Coll. Cardiol., May 1, 1999; 33(6): 1512 - 1518. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Marcoux, M. Tremblay, K. Nakajima, J. Davignon, and J. S. Cohn Characterization of remnant-like particles isolated by immunoaffinity gel from the plasma of type III and type IV hyperlipoproteinemic patients J. Lipid Res., April 1, 1999; 40(4): 636 - 647. [Abstract] [Full Text]
|
|
|
|
|
|
E. T. Leary, T. Wang, D. J. Baker, D. D. Cilla, J. Zhong, G. R. Warnick, K. Nakajima, and R. J. Havel Evaluation of an immunoseparation method for quantitative measurement of remnant-like particle-cholesterol in serum and plasma Clin. Chem., December 1, 1998; 44(12): 2490 - 2498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kugiyama, H. Doi, T. Motoyama, H. Soejima, K. Misumi, H. Kawano, O. Nakagawa, M. Yoshimura, H. Ogawa, T. Matsumura, et al. Association of Remnant Lipoprotein Levels With Impairment of Endothelium-Dependent Vasomotor Function in Human Coronary Arteries Circulation, June 30, 1998; 97(25): 2519 - 2526. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. McNamara, P. K. Shah, K. Nakajima, L. A. Cupples, P. W. F. Wilson, J. M. Ordovas, and E. J. Schaefer Remnant lipoprotein cholesterol and triglyceride reference ranges from the Framingham Heart Study Clin. Chem., June 1, 1998; 44(6): 1224 - 1232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kagawa, H. Matsutaka, C. Fukuhama, H. Fujino, and H. Okuda Suppressive Effect of Globin Digest on Postprandial Hyperlipidemia in Male Volunteers J. Nutr., January 1, 1998; 128(1): 56 - 60. [Abstract] [Full Text]
|
|
|
|
|
|
C. J. Packard and J. Shepherd Lipoprotein Heterogeneity and Apolipoprotein B Metabolism Arterioscler. Thromb. Vasc. Biol., December 1, 1997; 17(12): 3542 - 3556. [Abstract] [Full Text]
|
|
|
|
|
|
N. Bergeron and R. J. Havel Influence of Diets Rich in Saturated and Omega-6 Polyunsaturated Fatty Acids on the Postprandial Responses of Apolipoproteins B-48, B-100, E, and Lipids in Triglyceride-Rich Lipoproteins Arterioscler. Thromb. Vasc. Biol., December 1, 1995; 15(12): 2111 - 2121. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |