Journal of Lipid Research, Vol 33, 381-384, Copyright © 1992 by Lipid Research, Inc.
Effect of retinoids on nuclear retinoic acid receptors mRNA in adipose tissue of retinol-deficient rats
and F Chytil
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232.
In this study, we examined effects of retinol deficiency and three
retinoids, all-trans-retinoic acid, 13-cis-retinoic acid, and etretin, the
aromatic derivative of retinoic acid on nuclear retinoic acid receptor
isoforms alpha, beta, and gamma mRNA in rat adipose tissue. Retinol
deficiency caused an almost 50% decrease in isoform beta mRNA levels of
adipose tissue, whereas little change occurred in the abundance of alpha
and gamma isoforms transcripts in this tissue. Intragastric administration
of all-trans-retinoic acid to retinol- deficient rats increased the adipose
tissue retinoic acid receptor isoforms beta and gamma mRNA levels sixfold
and twofold, respectively, in 4 h as compared to adipose tissue of
retinol-deficient rats that were administered cottonseed oil. In contrast
to this, 13-cis-retinoic acid and etretin at equimolar doses were not
effective in inducing beta or gamma isoforms mRNA in retinol-deficient
rats. These results show that adipose tissue isoform beta responds to
retinol deficiency, and all-trans-retinoic acid rapidly induces beta and
gamma mRNA isoforms in this tissue. Thus, retinoic acid may regulate
expression of specific genes through its interaction with retinoic acid
receptors in adipocytes.
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