Journal of Lipid Research, Vol 34, 1709-1716, Copyright © 1993 by Lipid Research, Inc.
Metabolism of beta-muricholic acid in the hamster and prairie dog
S Miki, EH Mosbach, BI Cohen, T Mikami, R Infante, N Ayyad and CK McSherry
Department of Surgery, Beth Israel Medical Center, New York, NY 10003.
The metabolism of beta-muricholic acid was investigated in the prairie dog
and the hamster. Intravenous infusion into bile fistula hamsters showed
that beta-muricholic acid was extracted by the liver and secreted into the
bile (> 85% in 1 h). Hepatic extraction of this compound and cholic acid
in the prairie dog was not as rapid as in the hamster. In the bile of the
prairie dog, most (93%) of the administered beta-muricholic acid was
present as the taurine conjugate. In the hamster, 28% of infused
beta-muricholic acid was secreted in unconjugated form, 43% as the taurine
conjugate, and 22% as the glycine conjugate. In both species, the
administered compound underwent little biotransformation. After
intraduodenal injection of [6 alpha-3H]- labeled beta-muricholic acid into
bile fistula hamsters, the bile acid was rapidly secreted into the bile;
more than 80% of the administered radioactivity was recovered in 3 h. In
the prairie dog, biliary recovery after intraduodenal administration of
either beta-muricholic acid (43% in 3 h) or cholic acid (22% in 3 h) was
slower than in the hamster. After intragastric administration, more than
80% of beta- muricholic acid was recovered unchanged in feces of both
animal species.
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