HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Averna, M. Articles by Schonfeld, G. Search for Related Content PubMed PubMed Citation Articles by Averna, M. Articles by Schonfeld, G. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol 34, 1957-1967, Copyright © 1993 by Lipid Research, Inc.

ARTICLES

Postprandial lipemia in subjects with hypobetalipoproteinemia and a single intestinal allele for apoB-48

M Averna, RL Seip, K Mankowitz and G Schonfeld
Division of Atherosclerosis, Nutrition, and Lipid Research, Washington University School of Medicine, St. Louis, MO 63110.

Hypobetalipoproteinemia in many kindreds is associated with truncated forms of apoB-100. Mutations of the apoB gene specifying more than 20 different carboxyl terminal truncations of apoB have been identified ranging in length from apoB-2 to apoB-89. Truncations longer than apoB- 48 appear to be secreted only by liver, while truncations shorter than apoB-48 are secreted by liver as well as intestine. Thus, intestines of subjects heterozygous for truncations > apoB-48 contain two alleles producing apoB-48, while intestines of heterozygotes with truncations < apoB-48 contain only one allele producing apoB-48. Our aims were to assess whether intestinal fat absorption differed from normal in subjects with apoB-truncation-associated hypobetalipoproteinemia and whether fat absorption in heterozygotes with apoB < 48 differed from heterozygotes with apoB > 48. Ten subjects heterozygous for apoB > 48 (apoBs -89, -75, -54, -52), six heterozygous for apoB < 48 (apoBs -46, - 40, -31) and a group of 16 controls matched for age, sex, body mass index characteristics, and eating similar diets were given identical fat meals containing vitamin A. Plasma triglycerides in whole plasma and retinyl palmitate in chylomicron and non-chylomicron (remnant) fractions were analyzed at zero time and over the next 14 hours. Fasting vitamins A and E also were quantified. Fasting plasma levels of vitamin E were lower in heterozygotes (536 +/- 198 mg/l for apoB > 48 vs. 372 +/- 155 for apoB < 48) versus controls (1162 +/- 441), but were not different when corrected for differences in LDL-C. Plasma vitamin A levels (uncorrected) were not different. Meal responses were characterized in terms of peak concentrations and areas under the curves (after subtraction of minimum points). These indices of fat absorption were comparable in all apoB phenotype groups suggesting that one allele specifying the intestinal production of apoB-48 is sufficient for normal fat absorption.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				A. J. Hooper, K. Robertson, P. H. R. Barrett, K. G. Parhofer, F. M. van Bockxmeer, and J. R. Burnett Postprandial Lipoprotein Metabolism in Familial Hypobetalipoproteinemia J. Clin. Endocrinol. Metab., April 1, 2007; 92(4): 1474 - 1478. [Abstract] [Full Text] [PDF]

				X. Lin, P. Yue, Y. Xie, N. O. Davidson, N. Sakata, R. E. Ostlund Jr., Z. Chen, and G. Schonfeld Reduced intestinal fat absorptive capacity but enhanced susceptibility to diet-induced fatty liver in mice heterozygous for ApoB38.9 truncation Am J Physiol Gastrointest Liver Physiol, July 1, 2005; 289(1): G146 - G152. [Abstract] [Full Text] [PDF]

				P. Tarugi, A. Lonardo, C. Gabelli, F. Sala, G. Ballarini, I. Cortella, L. Previato, S. Bertolini, R. Cordera, and S. Calandra Phenotypic expression of familial hypobetalipoproteinemia in three kindreds with mutations of apolipoprotein B gene J. Lipid Res., October 1, 2001; 42(10): 1552 - 1561. [Abstract] [Full Text] [PDF]

				K. G. Parhofer, P. H. R. Barrett, and P. Schwandt Atorvastatin Improves Postprandial Lipoprotein Metabolism in Normolipidemic Subjects J. Clin. Endocrinol. Metab., November 1, 2000; 85(11): 4224 - 4230. [Abstract] [Full Text]

				X.-F. Zhu, D. Noto, R. Seip, A. Shaish, and G. Schonfeld Organ Loci of Catabolism of Short Truncations of ApoB Arterioscler. Thromb. Vasc. Biol., June 1, 1997; 17(6): 1032 - 1038. [Abstract] [Full Text]