Journal of Lipid Research, Vol 34, 239-247, Copyright © 1993 by Lipid Research, Inc.

ARTICLES

Effect of a high linoleate and a high alpha-linolenate diet on general behavior and drug sensitivity in mice

Y Nakashima, S Yuasa, Y Hukamizu, H Okuyama, T Ohhara, T Kameyama and T Nabeshima
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.

Semi-purified diets supplemented with either a high linoleate (n-6) (safflower) oil or a high alpha-linolenate (n-3) (perilla) oil were fed to mouse mothers and their offspring through 6 weeks of age. The proportions of n-3 and n-6 highly unsaturated fatty acids in brain phospholipids reflected the n-3/n-6 balance of the diets while no difference was found in phospholipid compositions or cholesterol/phospholipid ratios. In the elevated plus maze task, the total number of entries into the open- and enclosed-arms was smaller and the time spent in the dark enclosed arms tended to be longer in the perilla group than the safflower group. The time required to reach a safe platform in Morris's water maze test was less in the perilla group, but no significant difference was observed in the entries into the arms darkened with a movable cover in Y-maze dark-preference task. The safflower group was more sensitive to pentobarbital; the anesthesia onset time was less and the anesthetic time was longer than in the perilla group. Increased locomotion induced by scopolamine injection was less in the safflower group as compared with the perilla group. These results indicate that in mice the dietary alpha- linolenate/linoleate balance affects the n-3/n-6 ratio of brain phospholipid acyl chains and that this is accompanied by general behavioral changes as well as changes in sensitivities to drugs known to affect behavior.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				J. C McCann and B. N Ames Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals Am. J. Clinical Nutrition, August 1, 2005; 82(2): 281 - 295. [Abstract] [Full Text] [PDF]

				J. Denomme, K. D. Stark, and B. J. Holub Directly Quantitated Dietary (n-3) Fatty Acid Intakes of Pregnant Canadian Women Are Lower than Current Dietary Recommendations J. Nutr., February 1, 2005; 135(2): 206 - 211. [Abstract] [Full Text] [PDF]

				E. FARKAS, M. C. DE WILDE, A. J. KILIAAN, and P. G. M. LUITEN Systemic Effects of Dietary n-3 PUFA Supplementation Accompany Changes of CNS Parameters in Cerebral Hypoperfusion Ann. N.Y. Acad. Sci., November 1, 2002; 977(1): 77 - 86. [Abstract] [Full Text] [PDF]

				T. Moriguchi, J. Loewke, M. Garrison, J. N. Catalan, and N. Salem , Jr. Reversal of docosahexaenoic acid deficiency in the rat brain, retina, liver, and serum J. Lipid Res., March 1, 2001; 42(3): 419 - 427. [Abstract] [Full Text]

				A. Ikemoto, A. Fukuma, Y. Fujii, and H. Okuyama Lysosomal Enzyme Activities Are Decreased in the Retina and Their Circadian Rhythms Are Different from Those in the Pineal Gland of Rats Fed an {{alpha}}-Linolenic Acid-Restricted Diet J. Nutr., December 1, 2000; 130(12): 3059 - 3062. [Abstract] [Full Text] [PDF]

				I. Carrié, M. Clément, D. de Javel, H. Francès, and J.-M. Bourre Specific phospholipid fatty acid composition of brain regions in mice: effects of n;-3 polyunsaturated fatty acid deficiency and phospholipid supplementation J. Lipid Res., March 1, 2000; 41(3): 465 - 472. [Abstract] [Full Text]

				I. Carrié, M. Clément, D. de Javel, H. Francès, and J.-M. Bourre Phospholipid supplementation reverses behavioral and biochemical alterations induced by n;-3 polyunsaturated fatty acid deficiency in mice J. Lipid Res., March 1, 2000; 41(3): 473 - 480. [Abstract] [Full Text]

				M. Umezawa, K. Kogishi, H. Tojo, S. Yoshimura, N. Seriu, A. Ohta, T. Takeda, and M. Hosokawa High-Linoleate and High-{alpha}-Linolenate Diets Affect Learning Ability and Natural Behavior in SAMR1 Mice J. Nutr., February 1, 1999; 129(2): 431 - 437. [Abstract] [Full Text] [PDF]

				S. Chalon, S. Delion-Vancassel, C. Belzung, D. Guilloteau, A.-M. Leguisquet, J.-C. Besnard, and G. Durand Dietary Fish Oil Affects Monoaminergic Neurotransmission and Behavior in Rats J. Nutr., December 1, 1998; 128(12): 2512 - 2519. [Abstract] [Full Text]

				C. Belzung, A.-M. Leguisquet, S. Barreau, S. Delion-Vancassel, S. Chalon, and G. Durand alpha -Linolenic Acid Deficiency Modifies Distractibility but Not Anxiety and Locomotion in Rats during Aging J. Nutr., September 1, 1998; 128(9): 1537 - 1542. [Abstract] [Full Text]

				P. E. Wainwright, H.-C. Xing, L. Mutsaers, D. McCutcheon, and D. Kyle Arachidonic Acid Offsets the Effects on Mouse Brain and Behavior of a Diet with a Low (n-6):(n-3) Ratio and Very High Levels of Docosahexaenoic Acid J. Nutr., January 1, 1997; 127(1): 184 - 193. [Abstract] [Full Text]