| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Lipid Research, Vol 34, 617-623, Copyright © 1993 by Lipid Research, Inc.
A Walsh, N Azrolan, K Wang, A Marcigliano, A O'Connell and JL Breslow
The apoA-I gene in humans is principally expressed in liver and small
intestine. Using transgenic mice, we previously showed that 256 bp of 5'
flanking DNA was sufficient for liver expression, but as much as 5.5 kb of
5' and 4.0 kb of 3' DNA did not allow intestinal expression of the human
apoA-I transgene. In the current study, a 10.5 kb DNA construction
containing the apoA-I and the adjacent convergently transcribed apoC-III
genes, which extends from 300 bp 5' to the apoA-I gene to 2.5 kb 5' to the
apoC-III gene, produced high levels of apoA-I intestinal expression. A
similar DNA construction ending 1.4 kb 5' to the apoC-III gene also allowed
apoA-I intestinal expression. The DNA region from 0.2 to 1.4 kb 5' to the
apoC-III gene was then cloned 1.7 kb 3' to the apoA-I gene in both
orientations in the absence of apoC- III gene sequences. Intestinal apoA-I
expression was also achieved with both of these constructions. In summary,
these in vivo experiments suggest that the intestinal control region for
the apoA-I gene is distinct from the liver control region, resides 3' to
the gene in the promoter of the adjacent apoC-III gene, and has some
properties of a tissue-specific enhancer.
ARTICLES
Intestinal expression of the human apoA-I gene in transgenic mice is controlled by a DNA region 3' to the gene in the promoter of the adjacent convergently transcribed apoC-III gene
Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, New York, NY 10021-6399.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  H. Coste and J. C. Rodriguez Orphan Nuclear Hormone Receptor Rev-erbalpha Regulates the Human Apolipoprotein CIII Promoter J. Biol. Chem., July 19, 2002; 277(30): 27120 - 27129. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Ostos, D. Recalde, N. Baroukh, A. Callejo, M. Rouis, G. Castro, and M. M. Zakin Fructose Intake Increases Hyperlipidemia and Modifies Apolipoprotein Expression in Apolipoprotein AI-CIII-AIV Transgenic Mice J. Nutr., May 1, 2002; 132(5): 918 - 923. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Georgopoulos, H.-Y. Kan, C. Reardon-Alulis, and V. Zannis The SP1 sites of the human apoCIII enhancer are essential for the expression of the apoCIII gene and contribute to the hepatic and intestinal expression of the apoA-I gene in transgenic mice Nucleic Acids Res., December 15, 2000; 28(24): 4919 - 4929. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Vergnes, N. Baroukh, M. A. Ostos, G. Castro, N. Duverger, M. N. Nanjee, J. Najib, J.-C. Fruchart, N. E. Miller, M. M. Zakin, et al. Expression of Human Apolipoprotein A-I/C-III/A-IV Gene Cluster in Mice Induces Hyperlipidemia but Reduces Atherogenesis Arterioscler. Thromb. Vasc. Biol., October 1, 2000; 20(10): 2267 - 2274. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Boffelli, D. A. Zajchowski, Z. Yang, and R. M. Lawn Estrogen Modulation of Apolipoprotein(a) Expression. IDENTIFICATION OF A REGULATORY ELEMENT J. Biol. Chem., May 28, 1999; 274(22): 15569 - 15574. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Jong, M. H. Hofker, and L. M. Havekes Role of ApoCs in Lipoprotein Metabolism : Functional Differences Between ApoC1, ApoC2, and ApoC3 Arterioscler. Thromb. Vasc. Biol., March 1, 1999; 19(3): 472 - 484. [Full Text] [PDF]
|
|
|
|
|
|
S. Hatada, W. Kuziel, O. Smithies, and N. Maeda The Influence of Chromosomal Location on the Expression of Two Transgenes in Mice J. Biol. Chem., January 8, 1999; 274(2): 948 - 955. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. B. Nielsen, D. Kahn, T. Duell, H.-U. G. Weier, S. Taylor, and S. G. Young Apolipoprotein B Gene Expression in a Series of Human Apolipoprotein B Transgenic Mice Generated with recA-assisted Restriction Endonuclease Cleavage-modified Bacterial Artificial Chromosomes. AN INTESTINE-SPECIFIC ENHANCER ELEMENT IS LOCATED BETWEEN 54 AND 62 KILOBASES 5' TO THE STRUCTURAL GENE J. Biol. Chem., August 21, 1998; 273(34): 21800 - 21807. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Yang, D. Boffelli, N. Boonmark, K. Schwartz, and R. Lawn Apolipoprotein(a) Gene Enhancer Resides within a LINE Element J. Biol. Chem., January 9, 1998; 273(2): 891 - 897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. B. Nielsen, S. P. A. McCormick, V. Pierotti, C. Tam, M. D. Gunn, H. Shizuya, and S. G. Young Human Apolipoprotein B Transgenic Mice Generated with 207- and 145-Kilobase Pair Bacterial Artificial Chromosomes. EVIDENCE THAT A DISTANT 5'-ELEMENT CONFERS APPROPRIATE TRANSGENE EXPRESSION IN THE INTESTINE J. Biol. Chem., November 21, 1997; 272(47): 29752 - 29758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Dusing, A. G. Brickner, M. B. Thomas, and D. A. Wiginton Regulation of Duodenal Specific Expression of the Human Adenosine Deaminase Gene J. Biol. Chem., October 17, 1997; 272(42): 26634 - 26642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Lacorte, E. Ktistaki, A. Beigneux, V. I. Zannis, J. Chambaz, and I. Talianidis Activation of CAAT Enhancer-binding Protein delta (C/EBPdelta ) by Interleukin-1 Negatively Influences Apolipoprotein C-III Expression J. Biol. Chem., September 19, 1997; 272(38): 23578 - 23584. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. C.F. Oliveira, L. Ma, R. Milne, S. M. Marcovina, A. Inazu, H. Mabuchi, and A. R. Tall Cholesteryl Ester Transfer Protein Activity Enhances Plasma Cholesteryl Ester Formation: Studies in CETP Transgenic Mice and Human Genetic CETP Deficiency Arterioscler. Thromb. Vasc. Biol., June 1, 1997; 17(6): 1045 - 1052. [Abstract] [Full Text]
|
|
|
|
|
|
J. D. Fraser, D. Keller, V. Martinez, D. Santiso-Mere, R. Straney, and M. R. Briggs Utilization of Recombinant Adenovirus and Dominant Negative Mutants to Characterize Hepatocyte Nuclear Factor 4-regulated Apolipoprotein AI and CIII Expression J. Biol. Chem., May 23, 1997; 272(21): 13892 - 13898. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kardassis, I. Tzameli, M. Hadzopoulou-Cladaras, I. Talianidis, and V. Zannis Distal Apolipoprotein C-III Regulatory Elements F to J Act as a General Modular Enhancer for Proximal Promoters That Contain Hormone Response Elements: Synergism Between Hepatic Nuclear Factor-4 Molecules Bound to the Proximal Promoter and Distal Enhancer Sites Arterioscler. Thromb. Vasc. Biol., January 1, 1997; 17(1): 222 - 232. [Abstract] [Full Text]
|
|
|
|
|
|
H. C.F. Oliveira, R. A. Chouinard, L. B. Agellon, C. Bruce, L. Ma, A. Walsh, J. L. Breslow, and A. R. Tall Human Cholesteryl Ester Transfer Protein Gene Proximal Promoter Contains Dietary Cholesterol Positive Responsive Elements and Mediates Expression in Small Intestine and Periphery While Predominant Liver and Spleen Expression Is Controlled by 5'-distal Sequences. CIS-ACTING SEQUENCES MAPPED IN TRANSGENIC MICE J. Biol. Chem., December 13, 1996; 271(50): 31831 - 31838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Duverger, C. Viglietta, L. Berthou, F. Emmanuel, A. Tailleux, L. Parmentier-Nihoul, B. Laine, C. Fievet, G. Castro, J. C. Fruchart, et al. Transgenic Rabbits Expressing Human Apolipoprotein A-I in the Liver Arterioscler. Thromb. Vasc. Biol., December 1, 1996; 16(12): 1424 - 1429. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. Kardassis, M. Laccotripe, I. Talianidis, and V. Zannis Transcriptional Regulation of the Genes Involved in Lipoprotein Transport : The Role of Proximal Promoters and Long-range Regulatory Elements and Factors in Apolipoprotein Gene Regulation Hypertension, April 1, 1996; 27(4): 980 - 1008. [Full Text]
|
|
|
|
|
|
N. Azrolan, H. Odaka, J. L. Breslow, and E. A. Fisher Dietary Fat Elevates Hepatic ApoA-I Production by Increasing the Fraction of Apolipoprotein A-I mRNA in the Translating Pool J. Biol. Chem., August 25, 1995; 270(34): 19833 - 19838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Bisaha, T. C. Simon, J. I. Gordon, and J. L. Breslow Characterization of an Enhancer Element in the Human Apolipoprotein C-III Gene That Regulates Human Apolipoprotein A-I Gene Expression in the Intestinal Epithelium J. Biol. Chem., August 25, 1995; 270(34): 19979 - 19988. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. J. Dzau, G. H. Gibbons, B. K. Kobilka, R. M. Lawn, and R. E. Pratt Genetic Models of Human Vascular Disease Circulation, January 15, 1995; 91(2): 521 - 531. [Abstract] [Full Text]
|
|
|
|
|
|
H.-Y. Kan, S. Georgopoulos, and V. Zannis A Hormone Response Element in the Human Apolipoprotein CIII (ApoCIII) Enhancer Is Essential for Intestinal Expression of the ApoA-I and ApoCIII Genes and Contributes to the Hepatic Expression of the Two Linked Genes in Transgenic Mice J. Biol. Chem., September 22, 2000; 275(39): 30423 - 30431. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |
