Journal of Lipid Research, Vol 34, 1445-1450, Copyright © 1993 by Lipid Research, Inc.
Changes in biliary lipid secretion during normal development and diurnal cycling in the rat
SJ Robins, JM Fasulo, PD Lessard and GM Patton
Division of Lipid Metabolism, Boston VA Medical Center, MA 02130.
Biliary lipid secretion in conjunction with hepatic cholesterol synthesis
was determined in normal male rats at 4, 5, 7, and 9 weeks of age, during a
period of linear growth and a near fourfold increase in liver size. Studies
were performed both at periods of low (mid-light cycle) and high (mid-dark
cycle) hepatic cholesterol synthesis. Biliary bile salt, phospholipid, and
cholesterol secretion (per g of liver) markedly decreased with an increase
in liver size. Whereas the secretion of bile salts and phospholipid was not
significantly different in mid-dark and mid-light periods for animals of
the same age, cholesterol secretion was greater in the mid-dark than in the
mid- light period at 5, 7, and 9 weeks of age. Relationships between
biliary cholesterol secretion and bile salt and phospholipid secretion
differed at mid-dark and mid-light periods, as follows: cholesterol
secretion was not significantly related to bile salt secretion at mid-dark
(r = 0.49, P > 0.05) but was related at mid-light (r = 0.73, P = 0.003);
and although cholesterol secretion was significantly related to
phospholipid secretion at mid-dark, this relationship was not nearly as
strong as at mid-light (P < 0.005, comparing r = 0.95 at mid-light with
r = 0.53 at mid-dark). In contrast, at mid-dark, biliary cholesterol
secretion was strongly related to hepatic cholesterol synthesis (r = 0.84,
P < 0.0001) whereas at mid-light the two were not significantly related
(r = 0.13, P > 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
