HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hultin, M. Articles by Olivecrona, T. Search for Related Content PubMed PubMed Citation Articles by Hultin, M. Articles by Olivecrona, T. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol 35, 1850-1860, Copyright © 1994 by Lipid Research, Inc.

ARTICLES

Metabolism of emulsions containing medium- and long-chain triglycerides or interesterified triglycerides

M Hultin, A Mullertz, MA Zundel, G Olivecrona, TT Hansen, RJ Deckelbaum, YA Carpentier and T Olivecrona
Department of Medical Biochemistry and Biophysics, University of Umea, Sweden.

This study compares the clearing and metabolism of three different lipid emulsions. They had the same phospholipid emulsifier and similar particle sizes. In one (LLL) the core component was long-chain triglycerides (TG), the second (MMM/LLL) contained equal molar amounts of medium- and long-chain TG, the third (MLM) contained synthetic TG with medium-chain (M) fatty acids in the 1,3-positions and a long-chain (L) fatty acid in the 2-position. In model experiments with bovine lipoprotein lipase, the MMM component was hydrolyzed preferentially in the MMM/LLL emulsion so that the initial products were M fatty acids and M monoglycerides. The MLM emulsion, in contrast, gave M fatty acids and formation of L-MG (monoglyceride) throughout hydrolysis. For in vivo studies [3H]oleic acid was incorporated into the emulsion TG as marker for the long-chain component. After bolus injection to rats, the MMM/LLL and MLM emulsions were cleared more rapidly than the LLL emulsion. This was true at all TG loads studied (4-64 mg for a 200 g rat). The labeled oleic acid was oxidized somewhat more rapidly when administered in the MLM emulsion compared to the MMM/LLL emulsion. There were only slight differences in tissue distribution of label. Hence, differences in in vivo metabolism of the long-chain fatty acids were small compared to the marked differences in TG structure and in patterns of product release during in vitro lipolysis.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				K. Yasunaga, S. Saito, Y.-L. Zhang, A. Hernandez-Ono, and H. N. Ginsberg Effects of triacylglycerol and diacylglycerol oils on blood clearance, tissue uptake, and hepatic apolipoprotein B secretion in mice J. Lipid Res., May 1, 2007; 48(5): 1108 - 1121. [Abstract] [Full Text] [PDF]

				K. Qi, T. Seo, Z. Jiang, Y. A. Carpentier, and R. J. Deckelbaum Triglycerides in Fish Oil Affect the Blood Clearance of Lipid Emulsions Containing Long- and Medium-Chain Triglycerides in Mice J. Nutr., November 1, 2006; 136(11): 2766 - 2772. [Abstract] [Full Text] [PDF]

				C. Chambrier, M. Lauverjat, and P. Bouletreau Structured Triglyceride Emulsions in Parenteral Nutrition Nutr Clin Pract, August 1, 2006; 21(4): 342 - 350. [Abstract] [Full Text] [PDF]

				J. W. Kruimel, T. H. Naber, J. Adam van der Vliet, C. Carneheim, M. B. Katan, and J. B. Jansen Parenteral Structured Triglyceride Emulsion Improves Nitrogen Balance and Is Cleared Faster from the Blood in Moderately Catabolic Patients JPEN J Parenter Enteral Nutr, September 1, 2001; 25(5): 237 - 244. [Abstract] [PDF]

				A. M. van Bennekum, Y. Kako, P. H. Weinstock, E. H. Harrison, R. J. Deckelbaum, I. J. Goldberg, and W. S. Blaner Lipoprotein lipase expression level influences tissue clearance of chylomicron retinyl ester J. Lipid Res., March 1, 1999; 40(3): 565 - 574. [Abstract] [Full Text]