Journal of Lipid Research, Vol 35, 2105-2113, Copyright © 1994 by Lipid Research, Inc.

ARTICLES

Dietary ethanol is associated with reduced lipolysis of intestinally derived lipoproteins

HJ Pownall
Department of Medicine, Baylor College of Medicine, Houston, TX.

An acute oral fat load produces transient lipemia that is enhanced by the simultaneous ingestion of ethanol. This phenomenon has been reinvestigated in six normal subjects who consumed three different fat loads with and without ethanol. The fat loads consisted of saturated fat, polyunsaturated fat, or polyunsaturated fat enriched with omega-3 (n-3) fatty acids. Each fat load contained retinol as a marker for intestinally derived lipoproteins. Plasma levels of triglycerides, retinyl palmitate, and nonesterified fatty acid species were determined at several time points after consumption. Increasing the size of a saturated fat load increased postprandial lipemia and delayed retinyl palmitate clearance. Postprandial lipemia and plasma retinyl palmitate concentrations were lower when omega-3 or omega-6 (n-6) polyunsaturated fat was substituted for saturated fat. Preprandial ethanol increased postprandial lipemia, an effect that was most profound with the saturated fat load. Concurrently, oral ethanol also increased postprandial retinyl palmitate. Addition of ethanol to the fat loads had no effect on the plasma concentrations of fatty acids derived from peripheral tissue but appeared to decrease the plasma concentration of free fatty acids of dietary origin. These data support the hypothesis that preprandial ethanol is associated with impaired chylomicron hydrolysis that may be due to inhibition of plasma lipoprotein lipase. These findings are important to the search for the molecular mechanism of ethanolic hypertriglyceridemia and to the development of dietary guidelines for its control.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				J. R. Greenfield, K. Samaras, C. S. Hayward, D. J. Chisholm, and L. V. Campbell Beneficial Postprandial Effect of a Small Amount of Alcohol on Diabetes and Cardiovascular Risk Factors: Modification by Insulin Resistance J. Clin. Endocrinol. Metab., February 1, 2005; 90(2): 661 - 672. [Abstract] [Full Text] [PDF]

				B.-H. Chung, S. Doran, P. Liang, L. Osterlund, B. S. Cho, R. A Oster, B. Darnell, and F. Franklin Alcohol-mediated enhancement of postprandial lipemia: a contributing factor to an increase in plasma HDL and a decrease in risk of cardiovascular disease Am. J. Clinical Nutrition, September 1, 2003; 78(3): 391 - 399. [Abstract] [Full Text] [PDF]

				J. Budzynski, M. Klopocka, M. Swiatkowski, G. Pulkowski, and M. Ziolkowski LIPOPROTEIN(a) IN ALCOHOL-DEPENDENT MALE PATIENTS DURING A SIX-MONTH ABSTINENCE PERIOD Alcohol Alcohol., March 1, 2003; 38(2): 157 - 162. [Abstract] [Full Text] [PDF]

				R. V. Sekhar, F. Jahoor, A. C. White, H. J. Pownall, F. Visnegarwala, M. C. Rodriguez-Barradas, M. Sharma, P. J. Reeds, and A. Balasubramanyam Metabolic basis of HIV-lipodystrophy syndrome Am J Physiol Endocrinol Metab, August 1, 2002; 283(2): E332 - E337. [Abstract] [Full Text] [PDF]

				B. Verges, B. Guerci, V. Durlach, C. Galland-Jos, J. L. Paul, L. Lagrost, and P. Gambert Increased plasma apoA-IV level is a marker of abnormal postprandial lipemia: a study in normoponderal and obese subjects J. Lipid Res., December 1, 2001; 42(12): 2021 - 2029. [Abstract] [Full Text] [PDF]

				A. R. Sharrett, G. Heiss, L. E. Chambless, E. Boerwinkle, S. A. Coady, A. R. Folsom, and W. Patsch Metabolic and Lifestyle Determinants of Postprandial Lipemia Differ From Those of Fasting Triglycerides : The Atherosclerosis Risk in Communities (ARIC) Study Arterioscler. Thromb. Vasc. Biol., February 1, 2001; 21(2): 275 - 281. [Abstract] [Full Text] [PDF]

				J. Budzynski, J. Rybakowski, M. Swiatkowski, L. Torlinski, M. Klopocka, W. Kosmowski, and M. Ziolkowski NALTREXONE EXERTS A FAVOURABLE EFFECT ON PLASMA LIPIDS IN ABSTINENT PATIENTS WITH ALCOHOL DEPENDENCE Alcohol Alcohol., January 1, 2000; 35(1): 91 - 97. [Abstract] [Full Text] [PDF]

				S. Hadjadj, J.-L. Paul, L. Meyer, V. Durlach, B. Vergès, O. Ziegler, P. Drouin, and B. Guerci Delayed Changes in Postprandial Lipid in Young Normolipidemic Men after a Nocturnal Vitamin A Oral Fat Load Test J. Nutr., September 1, 1999; 129(9): 1649 - 1655. [Abstract] [Full Text]

				H. J. Pownall, C. M. Ballantyne, K. T. Kimball, S. L. Simpson, D. Yeshurun, and A. M. Gotto Jr Effect of Moderate Alcohol Consumption on Hypertriglyceridemia: A Study in the Fasting State Arch Intern Med, May 10, 1999; 159(9): 981 - 987. [Abstract] [Full Text] [PDF]