| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Lipid Research, Vol 35, 930-937, Copyright © 1994 by Lipid Research, Inc.
ARTICLES |
EZ Amri, G Ailhaud and PA Grimaldi
Centre de Biochimie (UMR 134 CNRS), Universite de Nice-Sophia Antipolis, Faculte des Sciences, France.
Fatty acids are important metabolic substrates for adipose tissue and act, in preadipose cells, as potent inducers of various proteins directly involved in their metabolism. We have investigated the long- term effects of fatty acids on the conversion process of preadipose Ob1771 cells to adipose cells. Chronic exposure of cells to palmitate led, in a dose-dependent manner, to a strong stimulation of cell differentiation; this effect was confined to terminal events whereas fatty acids did not affect expression of early genes related to commitment of adipoblasts to preadipose cells. Adipogenic action of fatty acids did not require their metabolism as 2-bromopalmitate, which is not metabolized by preadipose cells, was more effective than palmitate in inducing differentiation. The critical role of fatty acids occurred during the first 3 days of the differentiation process and led subsequently to an increase in the number of differentiated cells by means of enhancement of post-confluent mitoses and over-expression of terminal differentiation-related genes. These results thus provide, at the molecular level, a potential link observed in vivo between an increase in fatty acid supply induced by high-fat or high-carbohydrate diets and the hyperplastic development of adipose tissue.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  W. Guo, S. Wong, W. Xie, T. Lei, and Z. Luo Palmitate modulates intracellular signaling, induces endoplasmic reticulum stress, and causes apoptosis in mouse 3T3-L1 and rat primary preadipocytes Am J Physiol Endocrinol Metab, August 1, 2007; 293(2): E576 - E586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Guo, T. Pirtskhalava, T. Tchkonia, W. Xie, T. Thomou, J. Han, T. Wang, S. Wong, A. Cartwright, F. G. Hegardt, et al. Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity Am J Physiol Endocrinol Metab, April 1, 2007; 292(4): E1041 - E1051. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-K. Kim, M. Della-Fera, J. Lin, and C. A. Baile Docosahexaenoic Acid Inhibits Adipocyte Differentiation and Induces Apoptosis in 3T3-L1 Preadipocytes J. Nutr., December 1, 2006; 136(12): 2965 - 2969. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sekiya, J.-i. Osuga, H. Okazaki, N. Yahagi, K. Harada, W.-J. Shen, Y. Tamura, S. Tomita, Y. Iizuka, K. Ohashi, et al. Absence of Hormone-sensitive Lipase Inhibits Obesity and Adipogenesis in Lepob/ob Mice J. Biol. Chem., April 9, 2004; 279(15): 15084 - 15090. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Azain Role of fatty acids in adipocyte growth and development J Anim Sci, March 1, 2004; 82(3): 916 - 924. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Massiera, P. Saint-Marc, J. Seydoux, T. Murata, T. Kobayashi, S. Narumiya, P. Guesnet, E.-Z. Amri, R. Negrel, and G. Ailhaud Arachidonic acid and prostacyclin signaling promote adipose tissue development: a human health concern? J. Lipid Res., February 1, 2003; 44(2): 271 - 279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Pohl, A. Ring, and W. Stremmel Uptake of long-chain fatty acids in HepG2 cells involves caveolae: analysis of a novel pathway J. Lipid Res., August 1, 2002; 43(9): 1390 - 1399. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Gagnon, P. Dods, N. Roustan-Delatour, C.-S. Chen, and A. Sorisky Phosphatidylinositol-3,4,5-Trisphosphate Is Required for Insulin-Like Growth Factor 1-Mediated Survival of 3T3-L1 Preadipocytes Endocrinology, January 1, 2001; 142(1): 205 - 212. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Chen, J. J. Billadello, and D. J. Schneider Identification and Localization of a Fatty Acid Response Region in the Human Plasminogen Activator Inhibitor-1 Gene Arterioscler. Thromb. Vasc. Biol., December 1, 2000; 20(12): 2696 - 2701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. N. Dieudonne, R. Pecquery, M. C. Leneveu, and Y. Giudicelli Opposite Effects of Androgens and Estrogens on Adipogenesis in Rat Preadipocytes: Evidence for Sex and Site-Related Specificities and Possible Involvement of Insulin-Like Growth Factor 1 Receptor and Peroxisome Proliferator-Activated Receptor {gamma}2 Endocrinology, February 1, 2000; 141(2): 649 - 656. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bastie, D. Holst, D. Gaillard, C. Jehl-Pietri, and P. A. Grimaldi Expression of Peroxisome Proliferator-activated Receptor PPARdelta Promotes Induction of PPARgamma and Adipocyte Differentiation in 3T3C2 Fibroblasts J. Biol. Chem., July 30, 1999; 274(31): 21920 - 21925. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Dace, G. Sarkissian, L. Schneider, C. Martin-El Yazidi, J. Bonne, A. Margotat, R. Planells, and J. Torresani Transient Expression of c-erbA{beta}1 Messenger Ribonucleic Acid and {beta}1 Thyroid Hormone Receptor Early in Adipogenesis of Ob 17 Cells Endocrinology, July 1, 1999; 140(7): 2983 - 2990. [Abstract] [Full Text]
|
|
|
|
|
|
J. Gao and G. Serrero Adipose Differentiation Related Protein (ADRP) Expressed in Transfected COS-7 Cells Selectively Stimulates Long Chain Fatty Acid Uptake J. Biol. Chem., June 11, 1999; 274(24): 16825 - 16830. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Sartipy, G. Bondjers, and E. Hurt-Camejo Phospholipase A2 Type II Binds to Extracellular Matrix Biglycan : Modulation of Its Activity on LDL by Colocalization in Glycosaminoglycan Matrixes Arterioscler. Thromb. Vasc. Biol., December 1, 1998; 18(12): 1934 - 1941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mandrup, R. V. Sorensen, T. Helledie, J. Nohr, T. Baldursson, C. Gram, J. Knudsen, and K. Kristiansen Inhibition of 3T3-L1 Adipocyte Differentiation by Expression of Acyl-CoA-binding Protein Antisense RNA J. Biol. Chem., September 11, 1998; 273(37): 23897 - 23903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Okuno, K. Kajiwara, S. Imai, T. Kobayashi, N. Honma, T. Maki, K. Suruga, T. Goda, S. Takase, Y. Muto, et al. Perilla Oil Prevents the Excessive Growth of Visceral Adipose Tissue in Rats by Down-Regulating Adipocyte Differentiation J. Nutr., September 1, 1997; 127(9): 1752 - 1757. [Abstract] [Full Text]
|
|
|
|
|
|
D. Lacasa, E. Garcia, D. Henriot, B. Agli, and Y. Giudicelli Site-Related Specificities of the Control by Androgenic Status of Adipogenesis and Mitogen-Activated Protein Kinase Cascade/c-fos Signaling Pathways in Rat Preadipocytes Endocrinology, August 1, 1997; 138(8): 3181 - 3186. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Kliewer, S. S. Sundseth, S. A. Jones, P. J. Brown, G. B. Wisely, C. S. Koble, P. Devchand, W. Wahli, T. M. Willson, J. M. Lenhard, et al. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma PNAS, April 29, 1997; 94(9): 4318 - 4323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Brasaemle, T. Barber, A. R. Kimmel, and C. Londos Post-translational Regulation of Perilipin Expression. STABILIZATION BY STORED INTRACELLULAR NEUTRAL LIPIDS J. Biol. Chem., April 4, 1997; 272(14): 9378 - 9387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. Berk, S.-L. Zhou, C.-L. Kiang, D. Stump, M. Bradbury, and L. M. Isola Uptake of Long Chain Free Fatty Acids Is Selectively Up-regulated in Adipocytes of Zucker Rats with Genetic Obesity and Non-insulin-dependent Diabetes Mellitus J. Biol. Chem., March 28, 1997; 272(13): 8830 - 8835. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Sartipy, B. Johansen, G. Camejo, B. Rosengren, G. Bondjers, and E. Hurt-Camejo Binding of Human Phospholipase A2 Type II to Proteoglycans. DIFFERENTIAL EFFECT OF GLYCOSAMINOGLYCANS ON ENZYME ACTIVITY J. Biol. Chem., October 18, 1996; 271(42): 26307 - 26314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Teboul, D. Gaillard, L. Staccini, H. Inadera, E.-Z. Amri, and P. A. Grimaldi Thiazolidinediones and Fatty Acids Convert Myogenic Cells into Adipose-like Cells J. Biol. Chem., November 24, 1995; 270(47): 28183 - 28187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E.-Z. Amri, F.édér. Bonino, Gér. Ailhaud, N. A. Abumrad, and P. A. Grimaldi Cloning of a Protein That Mediates Transcriptional Effects of Fatty Acids in Preadipocytes J. Biol. Chem., February 3, 1995; 270(5): 2367 - 2371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bastie, S. Luquet, D. Holst, C. Jehl-Pietri, and P. A. Grimaldi Alterations of Peroxisome Proliferator-activated Receptor delta Activity Affect Fatty Acid-controlled Adipose Differentiation J. Biol. Chem., December 1, 2000; 275(49): 38768 - 38773. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. C. Schiller, G. D'Ippolito, R. Brambilla, B. A. Roos, and G. A. Howard Inhibition of Gap-Junctional Communication Induces the Trans-differentiation of Osteoblasts to an Adipocytic Phenotype in Vitro J. Biol. Chem., April 20, 2001; 276(17): 14133 - 14138. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |
