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Journal of Lipid Research, Vol 36, 462-472, Copyright © 1995 by Lipid Research, Inc.
H Campos, DM Dreon and RM Krauss
To test whether lipoprotein lipase or hepatic lipase activities are
associated with lipoprotein subclasses, and to assess the effects of
dietary manipulations on these associations, enzyme activities were
measured in postheparin plasma (75 U heparin/kg) from 43 healthy men who
were randomly allocated to a low-fat (24% fat, 60% carbohydrate) and a
high-fat (46% fat, 38% carbohydrate) diet for 6 weeks each in a cross-over
design. The high-fat diet significantly increased both lipoprotein lipase
(+20%, P = 0.02) and hepatic lipase (+8%, P = 0.007) activities. On both
diets, hepatic lipase activity was significantly positively correlated (P
< 0.01) with plasma apolipoprotein (apo)B concentrations, and with
levels of small dense low density lipoprotein (LDL) III, measured by
analytic ultracentrifugation as mass of lipoproteins of flotation rate
(Sof) 3-5, while lipoprotein lipase activity was inversely associated with
levels of LDL III (P < 0.05). Despite the cross-sectional correlations,
increased hepatic lipase activity was not significantly correlated with the
reduction in LDL III mass observed on the high-fat diet. Rather, changes in
hepatic lipase were correlated inversely with changes in small very low
density lipoproteins (VLDL) of Sof 20-40, and small intermediate density
lipoproteins (VLDL) of Sof 10-16. Moreover, changes in lipoprotein lipase
activity were not significantly correlated with changes in small LDL, but
were positively associated with changes in small IDL of Sof 10- 14, and
large LDL I of Sof 7-10. Thus, while increased levels of small dense LDL
are associated with a metabolic state characterized by relatively increased
hepatic lipase and decreased lipoprotein lipase activity, changes in these
enzymes do not appear to be primary determinants of diet-induced changes in
levels of this LDL subfraction. On the other hand, increased lipoprotein
lipase activity induced by high-fat feeding may contribute to the
accumulation in plasma of both large LDL I and small IDL, whereas increased
hepatic lipase may promote catabolism or clearance of triglyceride-rich
lipoprotein remnants.
ARTICLES
Associations of hepatic and lipoprotein lipase activities with changes in dietary composition and low density lipoprotein subclasses
Department of Molecular and Nuclear Medicine, Lawrence Berkely Laboratory, University of California, Berkeley 94720, USA.
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