|
 |
|
|||||||
|
|||||||||
Journal of Lipid Research, Vol 36, 672-684, Copyright © 1995 by Lipid Research, Inc.
P Mauriege, A Marette, C Atgie, C Bouchard, G Theriault, LK Bukowiecki, P Marceau, S Biron, A Nadeau and JP Despres
Lipolytic and lipoprotein lipase (LPL) activities were studied in isolated
human adipocytes obtained from two intraabdominal depots (round ligament
and omental) and from the subcutaneous abdominal region of nine severely
obese premenopausal women (with body mass indices ranging from 37 to 51
kg/m2), aged 36 +/- 3 yr, undergoing gastrointestinal surgery. Both fat
cell weight and LPL activity were significantly greater in round ligament
adipose cells than in subcutaneous abdominal or in omental adipocytes (P
< 0.05). The antilipolytic effect of insulin and the sensitivity to this
hormone were also higher in round ligament adipose cells than in omental
adipocytes (P < 0.05). Although epinephrine initiated a similar biphasic
profile of response in all cell types, the catecholamine promoted a weaker
inhibition of lipolysis in omental adipocytes than in subcutaneous
abdominal adipose cells (P < 0.05). In addition, a lack of regional
variation was found in the maximal antilipolysis initiated by UK 14304 and
the alpha 2-adrenoceptors was higher in both subcutaneous abdominal and
round ligament fat cells than in omental adipocytes. Moreover, the maximal
lipolytic response to isoproterenol or to agents acting at post-receptor
levels was not different among fat depots. Finally, a lower beta-adrenergic
lipolytic sensitivity associated with a reduced beta-adrenoceptor density
was observed in round ligament as compared to omental adipose cells. These
data suggest that in massively obese premenopausal women, omental and round
ligament adipose tissues show distinct metabolic properties that may
contribute to limit the impact of intraabdominal obesity.
ARTICLES
Regional variation in adipose tissue metabolism of severely obese premenopausal women
Physical Activity Sciences Laboratory, Laval University, Ste-Foy, Quebec, Canada.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  I. Lemieux, V. Drapeau, D. Richard, J. Bergeron, P. Marceau, S. Biron, and P. Mauriege Waist Girth Does Not Predict Metabolic Complications in Severely Obese Men. Diabetes Care, June 1, 2006; 29(6): 1417 - 1419. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Tchernof, C. Belanger, A.-S. Morisset, C. Richard, J. Mailloux, P. Laberge, and P. Dupont Regional differences in adipose tissue metabolism in women: minor effect of obesity and body fat distribution. Diabetes, May 1, 2006; 55(5): 1353 - 1360. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Travers, B. W. Jeffers, and R. H. Eckel Insulin Resistance during Puberty and Future Fat Accumulation J. Clin. Endocrinol. Metab., August 1, 2002; 87(8): 3814 - 3818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. van Harmelen, A. Dicker, M. Ryden, H. Hauner, F. Lonnqvist, E. Naslund, and P. Arner Increased Lipolysis and Decreased Leptin Production by Human Omental as Compared With Subcutaneous Preadipocytes Diabetes, July 1, 2002; 51(7): 2029 - 2036. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Johnson, S. K. Fried, F. X. Pi-Sunyer, and J. B. Albu Impaired insulin action in subcutaneous adipocytes from women with visceral obesity Am J Physiol Endocrinol Metab, January 1, 2001; 280(1): E40 - E49. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. L. Wajchenberg Subcutaneous and Visceral Adipose Tissue: Their Relation to the Metabolic Syndrome Endocr. Rev., December 1, 2000; 21(6): 697 - 738. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. Imbeault, C. Couillard, A. Tremblay, J-P. Despres, and P. Mauriege Reduced {alpha}2-adrenergic sensitivity of subcutaneous abdominal adipocytes as a modulator of fasting and postprandial triglyceride levels in men J. Lipid Res., September 1, 2000; 41(9): 1367 - 1375. [Abstract] [Full Text]
|
|
|
|
|
|
C. M. Halleux, P. J. Declerck, S. L. Tran, R. Detry, and S. M. Brichard Hormonal Control of Plasminogen Activator Inhibitor-1 Gene Expression and Production in Human Adipose Tissue: Stimulation by Glucocorticoids and Inhibition by Catecholamines J. Clin. Endocrinol. Metab., November 1, 1999; 84(11): 4097 - 4105. [Abstract] [Full Text]
|
|
|
|
|
|
P. Mauriege, P. Imbeault, D. Langin, M. Lacaille, N. Almeras, A. Tremblay, and J. P. Despres Regional and gender variations in adipose tissue lipolysis in response to weight loss J. Lipid Res., September 1, 1999; 40(9): 1559 - 1571. [Abstract] [Full Text]
|
|
|
|
|
|
J. B. Albu, M. Curi, M. Shur, L. Murphy, D. E. Matthews, and F. X. Pi-Sunyer Systemic resistance to the antilipolytic effect of insulin in black and white women with visceral obesity Am J Physiol Endocrinol Metab, September 1, 1999; 277(3): E551 - E560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Mauriege, M. Brochu, D. Prud'homme, A. Tremblay, A. Nadeau, S. Lemieux, and J. P. Despres Is Visceral Adiposity a Significant Correlate of Subcutaneous Adipose Cell Lipolysis in Men? J. Clin. Endocrinol. Metab., February 1, 1999; 84(2): 736 - 742. [Abstract] [Full Text]
|
|
|
|
 |
|
 F. Lonnqvist, A. Thorne, V. Large, and P. Arner Sex Differences in Visceral Fat Lipolysis and Metabolic Complications of Obesity Arterioscler Thromb Vasc Biol, July 1, 1997; 17(7): 1472 - 1480. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. Valet, D. Grujic, J. Wade, M. Ito, M. C. Zingaretti, V. Soloveva, S. R. Ross, R. A. Graves, S. Cinti, M. Lafontan, et al. Expression of Human alpha 2-Adrenergic Receptors in Adipose Tissue of beta 3-Adrenergic Receptor-deficient Mice Promotes Diet-induced Obesity J. Biol. Chem., October 27, 2000; 275(44): 34797 - 34802. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |