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Journal of Lipid Research, Vol 36, 705-713, Copyright © 1995 by Lipid Research, Inc.
AK Batta, GS Tint, S Shefer, D Abuelo and G Salen
Cholesta-5,8-dien-3 beta-ol (8-dehydrocholesterol) and cholesta-5,7- dien-3
beta-ol (7-dehydrocholesterol) were isolated from the fecal neutral sterol
fraction from homozygotes with Smith-Lemli-Opitz syndrome. The structures
of the sterols were conclusively established from their mass spectra and 1H
and 13C nuclear magnetic resonance spectra. It is probable that
8-dehydrocholesterol arises from 7- dehydrocholesterol and is not a direct
precursor of cholesterol.
ARTICLES
Identification of 8-dehydrocholesterol (cholesta-5,8-dien-3 beta-ol) in patients with Smith-Lemli-Opitz syndrome
Department of Medicine, University of Medicine and Dentistry-New Jersey Medical School, Newark 07103, USA.
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