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Journal of Lipid Research, Vol 36, 1264-1273, Copyright © 1995 by Lipid Research, Inc.
X Hebuterne, XD Wang, EJ Johnson, NI Krinsky and RM Russell
This study was done to examine the intestinal absorption and cleavage of
9-cis-beta-carotene in vivo. A micellar solution, containing either no
addition or 10 mumol of 9-cis- or all-trans-beta-carotene, was perfused for
2 h through the upper portion of the small intestine of ferrets. The
effluent of a mesenteric lymph duct cannulation was collected, as well as
intestinal mucosa scrapings, a portal blood sample, and a liver biopsy,
both before and after perfusion. Carotenoids and retinoids were measured by
reverse-phase, high performance liquid chromatography. 9-Cis- and
all-trans-beta-carotene were transported equally well into mesenteric
lymph, although the intestinal concentration of the corresponding isomer
was tenfold higher after perfusion of the 9-cis- isomer than after
perfusion of all-trans- beta-carotene. Regardless of which isomer was used,
perfusion of beta- carotene resulted in the biosynthesis of similar amounts
of retinoic acid in portal blood, liver, and intestine. However, after the
perfusion of all-trans-beta-carotene, all the retinoic acid formed was in
the all-trans- form, whereas the perfusion of 9-cis-beta-carotene resulted
in the biosynthesis of about 50% of the total retinoic acid as the
9-cis-isomer. We conclude that in the in vivo ferret model, 9-cis-
beta-carotene has a good bioavailability and is a precursor of 9-cis-
retinoic acid.
ARTICLES
Intestinal absorption and metabolism of 9-cis-beta-carotene in vivo: biosynthesis of 9-cis-retinoic acid
United States Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
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