HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Almendingen, K. Articles by Pedersen, J. I. Search for Related Content PubMed PubMed Citation Articles by Almendingen, K. Articles by Pedersen, J. I. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol 36, 1370-1384, Copyright © 1995 by Lipid Research, Inc.

ARTICLES

Effects of partially hydrogenated fish oil, partially hydrogenated soybean oil, and butter on serum lipoproteins and Lp[a] in men

K Almendingen, O Jordal, P Kierulf, B Sandstad and JI Pedersen
Institute for Nutrition Research, University of Oslo, Norway.

We have compared the effects of partially hydrogenated fish oil (PHFO- diet), partially hydrogenated soybean oil (PHSO-diet), and butterfat (butter-diet) on serum lipids and lipoprotein[a] in 31 young men. The three test margarines, which contributed 78% of total fat in the diets, were produced from 70% of butterfat, PHSO, or PHFO, each with 30% of soybean oil. Fat provided about 35% of energy, and trans fatty acids 0.9%, 8.5%, and 8.0% of energy in the butter-, the PHSO-, and the PHFO- diet, respectively. Dietary cholesterol was balanced by the addition of dried egg powder to the PHSO- and the butter-diet; thus all diets contained 420 mg dietary cholesterol per 10 MJ per day. The subjects consumed all three test diets for 19-21 days in a random order (crossover design). The serum levels of total and LDL-cholesterol were significantly elevated on the PHFO-diet (mean values 5.42 and 3.94 mmol/L, respectively) compared to the PHSO-diet (5.11 and 3.58 mmol/L, respectively) but not different from those on the butter-diet (5.32 and 3.81 mmol/L, respectively). LDL-cholesterol was significantly reduced on the PHSO-diet compared to the butter-diet. The level of HDL- cholesterol was significantly lower on the PHFO-diet (0.98 mmol/L) when compared to the butter-diet (1.05 mmol/L) and with border-line significance compared to the PHSO-diet (1.05 mmol/L). The ratio of LDL- to HDL-cholesterol was significantly higher on the PHFO-diet (4.20) when compared to both other test diets (3.85 and 3.65, respectively). No significant differences in triglyceride values were observed. Lp[a] increased and apoA-I decreased significantly after consumption of both the PHSO-diet and the PHFO-diet, compared to the butter-diet. In conclusion, our results indicate that consumption of PHFO may unfavorably affect lipid risk indicators for coronary heart disease at least to the same extent as butterfat. To what extent the observed effects are due to the content of monoene trans, diene trans, or to the long chain saturated fatty acids in PHFO remains to be elucidated.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				N. Zaima, T. Sugawara, D. Goto, and T. Hirata Trans geometric isomers of EPA decrease LXR{alpha}-induced cellular triacylglycerol via suppression of SREBP-1c and PGC-1{beta} J. Lipid Res., December 1, 2006; 47(12): 2712 - 2717. [Abstract] [Full Text] [PDF]

				G. P. Zaloga, K. A. Harvey, W. Stillwell, and R. Siddiqui Trans Fatty Acids and Coronary Heart Disease Nutr Clin Pract, October 1, 2006; 21(5): 505 - 512. [Abstract] [Full Text] [PDF]

				D. Mozaffarian, M. B. Katan, A. Ascherio, M. J. Stampfer, and W. C. Willett Trans Fatty Acids and Cardiovascular Disease N. Engl. J. Med., April 13, 2006; 354(15): 1601 - 1613. [Full Text] [PDF]

				T. Tholstrup and S. Samman Postprandial Lipoprotein(a) Is Affected Differently by Specific Individual Dietary Fatty Acids in Healthy Young Men J. Nutr., October 1, 2004; 134(10): 2550 - 2555. [Abstract] [Full Text] [PDF]

				P. M. Clifton, J. B. Keogh, and M. Noakes Trans Fatty Acids in Adipose Tissue and the Food Supply Are Associated with Myocardial Infarction J. Nutr., April 1, 2004; 134(4): 874 - 879. [Abstract] [Full Text] [PDF]

				H. Muller, A. S. Lindman, A. Blomfeldt, I. Seljeflot, and J. I. Pedersen A Diet Rich in Coconut Oil Reduces Diurnal Postprandial Variations in Circulating Tissue Plasminogen Activator Antigen and Fasting Lipoprotein (a) Compared with a Diet Rich in Unsaturated Fat in Women J. Nutr., November 1, 2003; 133(11): 3422 - 3427. [Abstract] [Full Text] [PDF]

				T. Huby, V. Afzal, C. Doucet, R. M. Lawn, E. L. Gong, M. J. Chapman, J. Thillet, and E. M. Rubin Regulation of the Expression of the Apolipoprotein(a) Gene: Evidence for a Regulatory Role of the 5' Distal Apolipoprotein(a) Transcription Control Region Enhancer in Yeast Artificial Chromosome Transgenic Mice Arterioscler. Thromb. Vasc. Biol., September 1, 2003; 23(9): 1633 - 1639. [Abstract] [Full Text] [PDF]

				R. P Mensink, P. L Zock, A. D. Kester, and M. B Katan Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials Am. J. Clinical Nutrition, May 1, 2003; 77(5): 1146 - 1155. [Abstract] [Full Text] [PDF]

				A. Baylin, E. K. Kabagambe, A. Ascherio, D. Spiegelman, and H. Campos High 18:2 Trans-Fatty Acids in Adipose Tissue Are Associated with Increased Risk of Nonfatal Acute Myocardial Infarction in Costa Rican Adults J. Nutr., April 1, 2003; 133(4): 1186 - 1191. [Abstract] [Full Text] [PDF]

				H. Muller, A. S. Lindman, A. L. Brantsaeter, and J. I. Pedersen The Serum LDL/HDL Cholesterol Ratio Is Influenced More Favorably by Exchanging Saturated with Unsaturated Fat Than by Reducing Saturated Fat in the Diet of Women J. Nutr., January 1, 2003; 133(1): 78 - 83. [Abstract] [Full Text] [PDF]

				References Circulation, December 17, 2002; 106(25): 3373 - 3421. [Full Text]

				N. M. de Roos, E. G. Schouten, and M. B. Katan Consumption of a Solid Fat Rich in Lauric Acid Results in a More Favorable Serum Lipid Profile in Healthy Men and Women than Consumption of a Solid Fat Rich in trans-Fatty Acids J. Nutr., February 1, 2001; 131(2): 242 - 245. [Abstract] [Full Text]

				A. H. Lichtenstein, L. M. Ausman, S. M. Jalbert, and E. J. Schaefer Effects of Different Forms of Dietary Hydrogenated Fats on Serum Lipoprotein Cholesterol Levels N. Engl. J. Med., June 24, 1999; 340(25): 1933 - 1940. [Abstract] [Full Text] [PDF]

				A. Ascherio, M. B. Katan, P. L. Zock, M. J. Stampfer, and W. C. Willett Trans Fatty Acids and Coronary Heart Disease N. Engl. J. Med., June 24, 1999; 340(25): 1994 - 1998. [Full Text]

				T. A. B. Sanders, F. R. Oakley, G. J. Miller, K. A. Mitropoulos, D. Crook, and M. F. Oliver Influence of n-6 versus n-3 Polyunsaturated Fatty Acids in Diets Low in Saturated Fatty Acids on Plasma Lipoproteins and Hemostatic Factors Arterioscler. Thromb. Vasc. Biol., December 1, 1997; 17(12): 3449 - 3460. [Abstract] [Full Text]

				B. A. Clevidence, J. T. Judd, E. J. Schaefer, J. L. Jenner, A. H. Lichtenstein, R. A. Muesing, J. Wittes, and M. E. Sunkin Plasma Lipoprotein (a) Levels in Men and Women Consuming Diets Enriched in Saturated, Cis-, or Trans-Monounsaturated Fatty Acids Arterioscler. Thromb. Vasc. Biol., September 1, 1997; 17(9): 1657 - 1661. [Abstract] [Full Text]

				K. Sundram, A. Ismail, K. C. Hayes, R. Jeyamalar, and R. Pathmanathan Trans (Elaidic) Fatty Acids Adversely Affect the Lipoprotein Profile Relative to Specific Saturated Fatty Acids in Humans J. Nutr., March 1, 1997; 127(3): 514 - 514. [Abstract] [Full Text]

				K. Almendingen, I. Seljeflot, B. Sandstad, and J. I. Pedersen Effects of Partially Hydrogenated Fish Oil, Partially Hydrogenated Soybean Oil, and Butter on Hemostatic Variables in Men Arterioscler. Thromb. Vasc. Biol., March 1, 1996; 16(3): 375 - 380. [Abstract] [Full Text]