| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Lipid Research, Vol 37, 136-147, Copyright © 1996 by Lipid Research, Inc.
GM Dallinga-Thie, XD Bu, M van Linde-Sibenius Trip, JI Rotter, AJ Lusis and TW de Bruin
The underlying genetic abnormalities in familial combined hyperlipidemia
(FCH) have not been elucidated, although previous association and linkage
studies have implicated the apoA-I/C-III/A-IV gene cluster. We now report
studies of this cluster in 18 probands, 390 family members (hyperlipidemic
relatives, n = 179; normolipidemic relatives, n = 211), and 177 spouses.
Three restriction enzyme polymorphisms, XmnI and MspI sites 5' of the
apoA-I gene and the SstI site in the 3' untranslated region of exon 4 of
the apoC-III gene, were examined. In hyperlipidemic relatives and FCH
probands, the frequency of each minor allele was significantly higher than
in spouses. Associated with the higher frequency of minor alleles were
elevated plasma cholesterol, triglycerides, LDL-cholesterol, apoB, and
apoC-III levels. Quantitative sib-pair analysis revealed linkage between
the MspI minor allele and plasma LDL cholesterol levels (P < 0.04). The
present data indicate that, while apoA-I/C-III/A-IV gene cluster is not the
primary cause of FCH, this cluster has a specific modifying effect on
plasma triglyceride and LDL cholesterol levels.
ARTICLES
Apolipoprotein A-I/C-III/A-IV gene cluster in familial combined hyperlipidemia: effects on LDL-cholesterol and apolipoproteins B and C- III
Department of Medicine and Endocrinology, University Hospital, Utrecht, The Netherlands.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  R. Mar-Heyming, M. Miyazaki, D. Weissglas-Volkov, N. A. Kolaitis, N. Sadaat, C. Plaisier, P. Pajukanta, R. M. Cantor, T. W.A. de Bruin, J. M. Ntambi, et al. Association of Stearoyl-CoA Desaturase 1 Activity With Familial Combined Hyperlipidemia Arterioscler. Thromb. Vasc. Biol., June 1, 2008; 28(6): 1193 - 1199. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M De Michele, A Iannuzzi, A Salvato, P Pauciullo, M Gentile, G Iannuzzo, S Panico, A Pujia, G M Bond, and P Rubba Impaired endothelium-dependent vascular reactivity in patients with familial combined hyperlipidaemia Heart, January 1, 2007; 93(1): 78 - 81. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F Cardona, F J Tinahones, E Collantes, A Escudero, E Garcia-Fuentes, and F J Soriguer Contribution of polymorphisms in the apolipoprotein AI-CIII-AIV cluster to hyperlipidaemia in patients with gout Ann Rheum Dis, January 1, 2005; 64(1): 85 - 88. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Mar, P. Pajukanta, H. Allayee, M. Groenendijk, G. Dallinga-Thie, R. M. Krauss, J. S. Sinsheimer, R. M. Cantor, T. W.A. de Bruin, and A. J. Lusis Association of the APOLIPOPROTEIN A1/C3/A4/A5 Gene Cluster With Triglyceride Levels and LDL Particle Size in Familial Combined Hyperlipidemia Circ. Res., April 16, 2004; 94(7): 993 - 999. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Eichenbaum-Voline, M. Olivier, E. L. Jones, R. P. Naoumova, B. Jones, B. Gau, H. N. Patel, M. Seed, D. J. Betteridge, D. J. Galton, et al. Linkage and Association Between Distinct Variants of the APOA1/C3/A4/A5 Gene Cluster and Familial Combined Hyperlipidemia Arterioscler. Thromb. Vasc. Biol., January 1, 2004; 24(1): 167 - 174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Naoumova, S. A. Bonney, S. Eichenbaum-Voline, H. N. Patel, B. Jones, E. L. Jones, J. Amey, S. Colilla, C. K.Y. Neuwirth, R. Allotey, et al. Confirmed Locus on Chromosome 11p and Candidate Loci on 6q and 8p for the Triglyceride and Cholesterol Traits of Combined Hyperlipidemia Arterioscler. Thromb. Vasc. Biol., November 1, 2003; 23(11): 2070 - 2077. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Allayee, L. W. Castellani, R. M. Cantor, T. W.A. de Bruin, and A. J. Lusis Biochemical and Genetic Association of Plasma Apolipoprotein A-II Levels With Familial Combined Hyperlipidemia Circ. Res., June 13, 2003; 92(11): 1262 - 1267. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Couillard, M.-C. Vohl, J. C. Engert, I. Lemieux, A. Houde, N. Almeras, D. Prud'homme, A. Nadeau, J.-P. Despres, and J. Bergeron Effect of apoC-III gene polymorphisms on the lipoprotein-lipid profile of viscerally obese men J. Lipid Res., May 1, 2003; 44(5): 986 - 993. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Allayee, K. L. Krass, P. Pajukanta, R. M. Cantor, C. J.H. van der Kallen, R. Mar, J. I. Rotter, T. W.A. de Bruin, L. Peltonen, and A. J. Lusis Locus for Elevated Apolipoprotein B Levels on Chromosome 1p31 in Families With Familial Combined Hyperlipidemia Circ. Res., May 3, 2002; 90(8): 926 - 931. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Dallinga-Thie, M. Groenendijk, R. N. H. H. C. Blom, T. W. A. De Bruin, and E. De Kant Genetic heterogeneity in the apolipoprotein C-III promoter and effects of insulin J. Lipid Res., September 1, 2001; 42(9): 1450 - 1456. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M.W. Geurts, R. G.J.H. Janssen, M. M.J. van Greevenbroek, C. J.H. van der Kallen, R. M. Cantor, X.-d. Bu, B. E. Aouizerat, H. Allayee, J. I. Rotter, and T. W.A. de Bruin Identification of TNFRSF1B as a novel modifier gene in familial combined hyperlipidemia Hum. Mol. Genet., September 1, 2000; 9(14): 2067 - 2074. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Hölzl, H. G. Kraft, H. Wiebusch, A. Sandhofer, J. Patsch, F. Sandhofer, and B. Paulweber wo novel mutations in the lipoprotein lipase gene in a family with marked hypertriglyceridemia in heterozygous carriers: potential interaction with the polymorphic marker D1S104 on chromosome 1q21-q23 J. Lipid Res., May 1, 2000; 41(5): 734 - 741. [Abstract] [Full Text]
|
|
|
|
|
|
H. Allayee, K. M. Dominguez, B. E. Aouizerat, R. M. Krauss, J. I. Rotter, J. Lu, R. M. Cantor, T. W. A. de Bruin, and A. J. Lusis Contribution of the hepatic lipase gene to the atherogenic lipoprotein phenotype in familial combined hyperlipidemia J. Lipid Res., February 1, 2000; 41(2): 245 - 252. [Abstract] [Full Text]
|
|
|
|
|
|
J. Pihlajamaki, L. Karjalainen, P. Karhapaa, I. Vauhkonen, and M. Laakso Impaired Free Fatty Acid Suppression During Hyperinsulinemia Is a Characteristic Finding in Familial Combined Hyperlipidemia, but Insulin Resistance Is Observed Only in Hypertriglyceridemic Patients Arterioscler. Thromb. Vasc. Biol., January 1, 2000; 20(1): 164 - 170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E. Aouizerat, H. Allayee, R. M. Cantor, G. M. Dallinga-Thie, C. D. Lanning, T. W. A. de Bruin, A. J. Lusis, and J. I. Rotter Linkage of a Candidate Gene Locus to Familial Combined Hyperlipidemia : Lecithin:Cholesterol Acyltransferase on 16q Arterioscler. Thromb. Vasc. Biol., November 1, 1999; 19(11): 2730 - 2736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Edwards, M. C. Mahaney, A. G. Motulsky, and M. A. Austin Pleiotropic Genetic Effects on LDL Size, Plasma Triglyceride, and HDL Cholesterol in Families Arterioscler. Thromb. Vasc. Biol., October 1, 1999; 19(10): 2456 - 2464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ribalta, J. Girona, J. C. Vallvé, A. E. La Ville, M. Heras, and L. Masana Vitamin A is linked to the expression of the AI-CIII-AIV gene cluster in familial combined hyperlipidemia J. Lipid Res., March 1, 1999; 40(3): 426 - 431. [Abstract] [Full Text]
|
|
|
|
|
|
M. C. Jong, M. H. Hofker, and L. M. Havekes Role of ApoCs in Lipoprotein Metabolism : Functional Differences Between ApoC1, ApoC2, and ApoC3 Arterioscler. Thromb. Vasc. Biol., March 1, 1999; 19(3): 472 - 484. [Full Text] [PDF]
|
|
|
|
 |
|
 H. Esterbauer, E. Hell, F. Krempler, and W. Patsch Allele-specific Differences in Apolipoprotein C-III mRNA Expression in Human Liver Clin. Chem., March 1, 1999; 45(3): 331 - 339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Vedie, X. Jeunemaitre, J. L. Megnien, I. Myara, H. Trebeden, A. Simon, and N. Moatti Charge Heterogeneity of LDL in Asymptomatic Hypercholesterolemic Men Is Related to Lipid Parameters and Variations in the ApoB and CIII Genes Arterioscler. Thromb. Vasc. Biol., November 1, 1998; 18(11): 1780 - 1789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Tahvanainen, P. Pajukanta, K. Porkka, S. Nieminen, L. Ikavalko, I. Nuotio, M.-R. Taskinen, L. Peltonen, and C. Ehnholm Haplotypes of the ApoA-I/C-III/A-IV Gene Cluster and Familial Combined Hyperlipidemia Arterioscler. Thromb. Vasc. Biol., November 1, 1998; 18(11): 1810 - 1817. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Wijsman, J. D. Brunzell, G. P. Jarvik, M. A. Austin, A. G. Motulsky, and S. S. Deeb Evidence Against Linkage of Familial Combined Hyperlipidemia to the Apolipoprotein AI-CIII-AIV Gene Complex Arterioscler. Thromb. Vasc. Biol., February 1, 1998; 18(2): 215 - 226. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Mann, A. A. Troussard, F. T. Yen, N. Hannouche, J. Najib, J.-C. Fruchart, V. Lotteau, P. Andre, and B. E. Bihain Inhibitory Effects of Specific Apolipoprotein C-III Isoforms on the Binding of Triglyceride-rich Lipoproteins to the Lipolysis-stimulated Receptor J. Biol. Chem., December 12, 1997; 272(50): 31348 - 31354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ribalta, A. E. LaVille, J. Girona, J. C. Vallve, and L. Masana Low plasma vitamin A concentrations in familial combined hyperlipidemia Clin. Chem., December 1, 1997; 43(12): 2379 - 2383. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Stroes, T. de Bruin, H. de Valk, W. Erkelens, J.-D. Banga, H. van Rijn, H. Koomans, and T. Rabelink NO activity in familial combined hyperlipidemia: potential role of cholesterol remnants Cardiovasc Res, December 1, 1997; 36(3): 445 - 452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.J.H. Bredie, J. van Drongelen, L.A. Kiemeney, P.N.M. Demacker, T.H. Beaty, and A.F.H. Stalenhoef Segregation Analysis of Plasma Apolipoprotein B Levels in Familial Combined Hyperlipidemia Arterioscler. Thromb. Vasc. Biol., May 1, 1997; 17(5): 834 - 840. [Abstract] [Full Text]
|
|
|
|
|
|
H. Allayee, K. L. Krass, P. Pajukanta, R. M. Cantor, C. J.H. van der Kallen, R. Mar, J. I. Rotter, T. W.A. de Bruin, L. Peltonen, and A. J. Lusis Locus for Elevated Apolipoprotein B Levels on Chromosome 1p31 in Families With Familial Combined Hyperlipidemia Circ. Res., May 3, 2002; 90(8): 926 - 931. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |
