| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Lipid Research, Vol 37, 439-447, Copyright © 1996 by Lipid Research, Inc.
GR Thompson, RP Naoumova and GF Watts
The review examines the evidence that the supply of cholesterol available
for incorporation into nascent lipoprotein particles exerts a regulatory
influence on apolipoprotein (apo) B secretion by the liver. Support for
this hypothesis comes both from in vitro experiments and from recent
observations in normal subjects and patients with dyslipidemia associated
with familial hypercholesterolemia, obesity, noninsulin dependent diabetes
mellitus, growth hormone deficiency and cholesteryl ester storage disease.
The findings do not negate a role for triglyceride synthesis in determining
apoB secretion in very low density lipoprotein, but the inhibitory effects
on the latter process of pharmacological blockade of cholesterol synthesis
or esterification suggest that it is conditional upon an adequate supply of
cholesteryl ester.
REVIEWS
Role of cholesterol in regulating apolipoprotein B secretion by the liver
Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  H. N. Ginsberg REVIEW: Efficacy and Mechanisms of Action of Statins in the Treatment of Diabetic Dyslipidemia J. Clin. Endocrinol. Metab., February 1, 2006; 91(2): 383 - 392. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Hapon, S. M. Varas, G. A. Jahn, and M. S. Gimenez Effects of hypothyroidism on mammary and liver lipid metabolism in virgin and late-pregnant rats J. Lipid Res., June 1, 2005; 46(6): 1320 - 1330. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G D Kolovou, K K Anagnostopoulou, and D V Cokkinos Pathophysiology of dyslipidaemia in the metabolic syndrome Postgrad. Med. J., June 1, 2005; 81(956): 358 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M. Lewin, S. Wang, C. A. Nagle, C. G. Van Horn, and R. A. Coleman Mitochondrial glycerol-3-phosphate acyltransferase-1 directs the metabolic fate of exogenous fatty acids in hepatocytes Am J Physiol Endocrinol Metab, May 1, 2005; 288(5): E835 - E844. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D.C. Chan, G.F. Watts, P.H.R. Barrett, A.J. Whitfield, and F.M. van Bockxmeer ATP-Binding Cassette Transporter G8 Gene As a Determinant of Apolipoprotein B-100 Kinetics in Overweight Men Arterioscler. Thromb. Vasc. Biol., November 1, 2004; 24(11): 2188 - 2191. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bilz, S. Wagner, M. Schmitz, A. Bedynek, U. Keller, and T. Demant Effects of atorvastatin versus fenofibrate on apoB-100 and apoA-I kinetics in mixed hyperlipidemia J. Lipid Res., January 1, 2004; 45(1): 174 - 185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. H. C. M. T. Prinsen, J. A. Romijn, P. H. Bisschop, M. M. J. de Barse, P. H. R. Barrett, M. Ackermans, R. Berger, T. J. Rabelink, and M. G. M. de Sain-van der Velden Endogenous cholesterol synthesis is associated with VLDL-2 apoB-100 production in healthy humans J. Lipid Res., July 1, 2003; 44(7): 1341 - 1348. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. C. Chan, G. F. Watts, P. H. R. Barrett, L. J. Beilin, T. G. Redgrave, and T. A. Mori Regulatory Effects of HMG CoA Reductase Inhibitor and Fish Oils on Apolipoprotein B-100 Kinetics in Insulin-Resistant Obese Male Subjects With Dyslipidemia Diabetes, August 1, 2002; 51(8): 2377 - 2386. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Roglans, E. Sanguino, C. Peris, M. Alegret, M. Vazquez, T. Adzet, C. Diaz, G. Hernandez, J. C. Laguna, and R. M. Sanchez Atorvastatin Treatment Induced Peroxisome Proliferator-Activated Receptor alpha Expression and Decreased Plasma Nonesterified Fatty Acids and Liver Triglyceride in Fructose-Fed Rats J. Pharmacol. Exp. Ther., July 1, 2002; 302(1): 232 - 239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Chan, G. F. Watts, P. H. R. Barrett, T. A. Mori, L. J. Beilin, and T. G. Redgrave Mechanism of Action of a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor on Apolipoprotein B-100 Kinetics in Visceral Obesity J. Clin. Endocrinol. Metab., May 1, 2002; 87(5): 2283 - 2289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Y. Chang, C. C. Y. Chang, X. Lu, and S. Lin Catalysis of ACAT may be completed within the plane of the membrane: a working hypothesis J. Lipid Res., December 1, 2001; 42(12): 1933 - 1938. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. L. Volger, H. van der Boom, E. C. M. de Wit, W. van Duyvenvoorde, G. Hornstra, J. Plat, L. M. Havekes, R. P. Mensink, and H. M. G. Princen Dietary Plant Stanol Esters Reduce VLDL Cholesterol Secretion and Bile Saturation in Apolipoprotein E*3-Leiden Transgenic Mice Arterioscler. Thromb. Vasc. Biol., June 1, 2001; 21(6): 1046 - 1052. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Maugeais, K. Ouguerram, R. Frénais, P. Maugère, B. Charbonnel, T. Magot, and M. Krempf Effect of Low-Density Lipoprotein Apheresis on Kinetics of Apolipoprotein B in Heterozygous Familial Hypercholesterolemia J. Clin. Endocrinol. Metab., April 1, 2001; 86(4): 1679 - 1686. [Abstract] [Full Text]
|
|
|
|
 |
|
 G.F. WATTS, S. HERRMANN, and F.M. RICHES Effects of diet and serotonergic agonist on hepatic apolipoprotein B-100 secretion and endothelial function in obese men QJM, March 1, 2000; 93(3): 153 - 161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Burnett, L. J. Wilcox, D. E. Telford, S. J. Kleinstiver, P. H. R. Barrett, R. S. Newton, and M. W. Huff The Magnitude of Decrease in Hepatic Very Low Density Lipoprotein Apolipoprotein B Secretion Is Determined by the Extent of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibition in Miniature Pigs Endocrinology, November 1, 1999; 140(11): 5293 - 5302. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. Lin, D. Cheng, M.-S. Liu, J. Chen, and T.-Y. Chang Human Acyl-CoA:Cholesterol Acyltransferase-1 in the Endoplasmic Reticulum Contains Seven Transmembrane Domains J. Biol. Chem., August 13, 1999; 274(33): 23276 - 23285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. M. Riches, G. F. Watts, J. Hua, G. R. Stewart, R. P. Naoumova, and P. H. R. Barrett Reduction in Visceral Adipose Tissue Is Associated with Improvement in Apolipoprotein B-100 Metabolism in Obese Men J. Clin. Endocrinol. Metab., August 1, 1999; 84(8): 2854 - 2861. [Abstract] [Full Text]
|
|
|
|
|
|
J. R. Burnett, L. J. Wilcox, D. E. Telford, S. J. Kleinstiver, P. H. R. Barrett, R. S. Newton, and M. W. Huff Inhibition of ACAT by avasimibe decreases both VLDL and LDL apolipoprotein B production in miniature pigs J. Lipid Res., July 1, 1999; 40(7): 1317 - 1328. [Abstract] [Full Text]
|
|
|
|
|
|
Z. Zhang, K. Cianflone, and A. D. Sniderman Role of Cholesterol Ester Mass in Regulation of Secretion of ApoB100 Lipoprotein Particles by Hamster Hepatocytes and Effects of Statins on That Relationship Arterioscler. Thromb. Vasc. Biol., March 1, 1999; 19(3): 743 - 752. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. S. Shelness, M. F. Ingram, X. F. Huang, and J. A. DeLozier Apolipoprotein B in the Rough Endoplasmic Reticulum: Translation, Translocation and the Initiation of Lipoprotein Assembly J. Nutr., February 1, 1999; 129(2): 456 - 456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. M. Riches, G. F. Watts, F. M. van Bockxmeer, J. Hua, S. Song, S. E. Humphries, and P. J. Talmud Apolipoprotein B signal peptide and apolipoprotein E genotypes as determinants of the hepatic secretion of VLDL apoB in obese men J. Lipid Res., September 1, 1998; 39(9): 1752 - 1758. [Abstract] [Full Text]
|
|
|
|
|
|
A. D. Sniderman, K. Cianflone, P. Arner, L. K. M. Summers, and K. N. Frayn The Adipocyte, Fatty Acid Trapping, and Atherogenesis Arterioscler. Thromb. Vasc. Biol., February 1, 1998; 18(2): 147 - 151. [Full Text] [PDF]
|
|
|
|
|
|
J. R. Burnett, L. J. Wilcox, D. E. Telford, S. J. Kleinstiver, P. H. R. Barrett, R. S. Newton, and M. W. Huff Inhibition of HMG-CoA Reductase by Atorvastatin Decreases Both VLDL and LDL Apolipoprotein B Production in Miniature Pigs Arterioscler. Thromb. Vasc. Biol., November 1, 1997; 17(11): 2589 - 2600. [Abstract] [Full Text]
|
|
|
|
 |
|
 V. L. Meiner, S. Cases, H. M. Myers, E. R. Sande, S. Bellosta, M. Schambelan, R. E. Pitas, J. McGuire, J. Herz, and R. V. Farese Jr. Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: Evidence suggesting multiple cholesterol esterification enzymes in mammals PNAS, November 26, 1996; 93(24): 14041 - 14046. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Y. Chang, N. Sakashita, K. Ornvold, O. Lee, E. T. Chang, R. Dong, S. Lin, C.-Y. G. Lee, S. C. Strom, R. Kashyap, et al. Immunological Quantitation and Localization of ACAT-1 and ACAT-2 in Human Liver and Small Intestine J. Biol. Chem., September 1, 2000; 275(36): 28083 - 28092. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |
