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Journal of Lipid Research, Vol 37, 708-726, Copyright © 1996 by Lipid Research, Inc.
AC Bach, Y Ingenbleek and A Frey
Compared to long-chain triglycerides (LCT), medium-chain triglycerides
(MCT) display some specific physico-chemical, and biological
characteristics. Thus, MCT are currently used in clinical nutrition as
energy-yielding substrates, and have been advocated for three decades as a
useful mean for body weight reduction. This review encompasses most aspects
of MCT metabolism arguing this slimming hypothesis pro and con. Findings in
support of the opinion (lower energy density, control of satiety, rapid
intrahepatic delivery and oxidation rates, poor adipose tissue
incorporation) may be invalidated by counteracting data (stimulation of
insulin secretion and of anabolic-related processes, increased de novo
fatty acid synthesis, induced hypertriglyceridemia). The balance between
these two opposing influences depends on the composition (energy intake,
nature of ingredients, MCT/LCT ratio, octanoate/decanoate ratio) and
duration of the regimen. Due to the high energy level (around 50%) of MCT
necessary to achieve body weight loss, long-term compliance to such
slimming regimens is unlikely in human nutrition.
REVIEWS
The usefulness of dietary medium-chain triglycerides in body weight control: fact or fancy?
CEPE, CNRS, Strasbourg, France.
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