| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Lipid Research, Vol 37, 1316-1324, Copyright © 1996 by Lipid Research, Inc.
K Bohnet, T Pillot, S Visvikis, N Sabolovic and G Siest
The clinical relevance of apoE concentration in lipoprotein fractions
should be evaluated. We investigated the impact of the common
apolipoprotein (apo) E polymorphism in conjunction with very low density
lipoprotein (VLDL) apoE concentration on the receptor binding properties of
VLDL preparations from 17 normolipidemic subjects of the HepG2 cell surface
receptors. All six apoE genotypes were studied. When apoE genotype alone
was considered, two subgroups could be distinguished: VLDL without apoE
isoform E2 (VLDL-3/3, VLDL-3/4, and VLDL-4/4) showed significantly higher
affinity than VLDL with apoE2 (VLDL-4/2, VLDL-3/2, and VLDL-2/2). Once we
adjusted for VLDL apoE content, we observed that VLDL affinity to HepG2
cell surface receptors decreased, according to apoE genotype, in the
following order: VLDL-4/4 (100%) > VLDL-3/4 (93%) > VLDL-3/3 (82%)
> VLDL-4/2 (53%) > VLDL-3/2 (36%) > VLDL-2/2 (30%). Moreover, we
found that VLDL apoE concentration could modify isoform-specific binding.
An analysis in 47 subjects showed that the concentration of total VLDL
protein and the VLDL apoE concentration varied considerably. The variation
of VLDL apoE was independent of apoE genotype and corresponding serum apoE
levels. We conclude that, in addition to apoE genotype, apoE content of
VLDL is an important determinant of the receptor binding properties of
VLDL.
ARTICLES
Apolipoprotein (apo) E genotype and apoE concentration determine binding of normal very low density lipoproteins to HepG2 cell surface receptors
Centre de Medecine Preventive, Vandoeuvre les Nancy, France.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Altenburg, J. Arbones-Mainar, L. Johnson, J. Wilder, and N. Maeda Human LDL Receptor Enhances Sequestration of ApoE4 and VLDL Remnants on the Surface of Hepatocytes but Not Their Internalization in Mice Arterioscler. Thromb. Vasc. Biol., June 1, 2008; 28(6): 1104 - 1110. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. V. Giannoudis, M. van Griensven, E. Tsiridis, and H. C. Pape The genetic predisposition to adverse outcome after trauma J Bone Joint Surg Br, October 1, 2007; 89-B(10): 1273 - 1279. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Altenburg, L. Johnson, J. Wilder, and N. Maeda Apolipoprotein E4 in Macrophages Enhances Atherogenesis in a Low Density Lipoprotein Receptor-dependent Manner J. Biol. Chem., March 16, 2007; 282(11): 7817 - 7824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Heeren, U. Beisiegel, and T. Grewal Apolipoprotein E Recycling: Implications for Dyslipidemia and Atherosclerosis Arterioscler. Thromb. Vasc. Biol., March 1, 2006; 26(3): 442 - 448. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. G. Jackson, V. Maitin, D. S. Leake, P. Yaqoob, and C. M. Williams Saturated fat-induced changes in Sf 60-400 particle composition reduces uptake of LDL by HepG2 cells J. Lipid Res., February 1, 2006; 47(2): 393 - 403. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Moreno, F. Perez-Jimenez, C. Marin, P. Perez-Martinez, R. Moreno, P. Gomez, Y. Jimenez-Gomez, J. A. Paniagua, D. Lairon, and J. Lopez-Miranda The Apolipoprotein E Gene Promoter (-219G/T) Polymorphism Determines Insulin Sensitivity in Response to Dietary Fat in Healthy Young Adults J. Nutr., November 1, 2005; 135(11): 2535 - 2540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Heeren, T. Grewal, A. Laatsch, N. Becker, F. Rinninger, K.-A. Rye, and U. Beisiegel Impaired Recycling of Apolipoprotein E4 Is Associated with Intracellular Cholesterol Accumulation J. Biol. Chem., December 31, 2004; 279(53): 55483 - 55492. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Liberopoulos, G. Miltiadous, M. Hatzivassiliou, N. Ayrton, E. Bairaktari, M. Cariolou, and M. Elisaf Apolipoprotein E Polymorphism in Northwestern Greece: Frequency and Effect on Lipid Parameters Ann. Clin. Lab. Sci., July 1, 2004; 34(3): 347 - 354. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M A Wozniak, E M Riley, and R F Itzhaki Apolipoprotein E polymorphisms and risk of malaria J. Med. Genet., March 1, 2004; 41(3): 145 - 146. [Full Text] [PDF]
|
|
|
|
|
|
S. I. Malloy, M. K. Altenburg, C. Knouff, L. Lanningham-Foster, J. S. Parks, and N. Maeda Harmful Effects of Increased LDLR Expression in Mice With Human APOE*4 But Not APOE*3 Arterioscler. Thromb. Vasc. Biol., January 1, 2004; 24(1): 91 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. DeKroon, M. Mihovilovic, Z. V. Goodger, J. B. Robinette, P. M. Sullivan, A. M. Saunders, and W. J. Strittmatter ApoE genotype-specific inhibition of apoptosis J. Lipid Res., August 1, 2003; 44(8): 1566 - 1573. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M A Wozniak, E B Faragher, J A Todd, K A Koram, E M Riley, and R F Itzhaki Does apolipoprotein E polymorphism influence susceptibility to malaria? J. Med. Genet., May 1, 2003; 40(5): 348 - 351. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Ballantyne, J. A. Herd, E. A. Stein, L. L. Ferlic, J. K. Dunn, A. M. Gotto Jr., and A. J. Marian Apolipoprotein E genotypes and response of plasma lipids and progression-regression of coronary atherosclerosis to lipid-lowering drug therapy J. Am. Coll. Cardiol., November 1, 2000; 36(5): 1572 - 1578. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-C. Lambert, T. Brousseau, V. Defosse, A. Evans, D. Arveiler, J.-B. Ruidavets, B. Haas, J.-P. Cambou, G. Luc, P. Ducimetiere, et al. Independent association of an APOE gene promoter polymorphism with increased risk of myocardial infarction and decreased APOE plasma concentrations--the ECTIM Study Hum. Mol. Genet., January 1, 2000; 9(1): 57 - 61. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. D. S. Mamotte, M. Sturm, J. I. Foo, F. M. van Bockxmeer, and R. R. Taylor Comparison of the LDL-receptor binding of VLDL and LDL from apoE4 and apoE3 homozygotes Am J Physiol Endocrinol Metab, March 1, 1999; 276(3): E553 - E557. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. H.-J. Schmidt, M. Stuhrmann, R. Shamburek, C. K. Schewe, M. Ebhardt, L. A. Zech, C. Büttner, M. Wendt, U. Beisiegel, H. B. Brewer, et al. Delayed Low Density Lipoprotein (LDL) Catabolism Despite a Functional Intact LDL-Apolipoprotein B Particle and LDL-Receptor in a Subject with Clinical Homozygous Familial Hypercholesterolemia J. Clin. Endocrinol. Metab., June 1, 1998; 83(6): 2167 - 2174. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Vincent-Viry, F. Schiele, R. Gueguen, K. Bohnet, S. Visvikis, and G. Siest Biological variations and genetic reference values for apolipoprotein E serum concentrations: results from the STANISLAS cohort study Clin. Chem., May 1, 1998; 44(5): 957 - 965. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |
