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Journal of Lipid Research, Vol 37, 1842-1848, Copyright © 1996 by Lipid Research, Inc.
KJ Halliwell, BA Fielding, JS Samra, SM Humphreys and KN Frayn
The objective of this study was to investigate the mobilization of
individual fatty acids from human subcutaneous adipose tissue in vivo.
Concentrations of individual non-esterified fatty acids were measured in
arterialized plasma and in the venous drainage from subcutaneous abdominal
adipose tissue in eight normal subjects, after an overnight fast, and for
the subsequent 6 h. Whilst the veno-arterial concentration difference for
non-esterified fatty acids increased over this period, the relative
proportions of different fatty acids remained constant. There was a close
relationship between veno-arterial difference and arterialized
concentration for the different fatty acids. The arterialized concentration
of stearic acid consistently lay above the regression line drawn for
unsaturated fatty acids (P = 0.001), probably reflecting lower clearance of
stearic acid. The release of individual fatty acids was compared with their
prevalence in adipose tissue triacylglycerol in biopsies taken from six
subjects. Relative release decreased with increasing chain length, and for
a given chain length increased with increasing unsaturation, in agreement
with animal studies (P < 0.001 for differences in relative mobilization
according to these two factors). The results suggest that the systemic
plasma concentration of individual non-esterified fatty acids is determined
by their release from adipose tissue, but that the relationship between
release and systemic concentration for stearic acid is different from that
for other fatty acids. The results confirm, in humans, differences in
relative mobilization found previously in animal studies.
ARTICLES
Release of individual fatty acids from human adipose tissue in vivo after an overnight fast
Nuffield Department of Clinical Medicine, Radcliffe Infirmary, United Kingdom.
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