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Journal of Lipid Research, Vol 38, 2249-2263, Copyright © 1997 by Lipid Research, Inc.
Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein
DL Brasaemle, T Barber, NE Wolins, G Serrero, EJ Blanchette-Mackie and C Londos
Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-2715, USA.
The adipose differentiation-related protein (ADRP) was first characterized
as a mRNA induced early during adipocyte differentiation (Jiang, H. P., and
G. Serrero. 1992. Proc. Natl. Acad. Sci. USA. 89:7856-7860). The present
study demonstrates that ADRP mRNA is expressed in a variety of tissues and
cultured cell lines. Immunocytochemical examination revealed that ADRP
localizes to neutral lipid storage droplets in cultured murine 3T3-L1
adipocytes, murine MA- 10 Leydig cells, Chinese hamster ovary (CHO)
fibroblasts, and human HepG2 hepatoma cells; the association of ADRP with
lipid droplets was confirmed by subcellular fractionation of MA-10 Leydig
cells. In addition to ADRP, steroidogenic cells and adipocytes express the
perilipins, a family of lipid droplet-associated proteins that share a
highly related sequence domain with ADRP. ADRP and perilipins co- localize
on lipid droplets in MA-10 Leydig cells. While ADRP was found on small
lipid droplets in 3T3-L1 preadipocytes and early differentiated adipocytes,
it was absent in maturing adipocytes. In contrast, perilipins were absent
early during differentiation, but were found on small and large lipid
droplets at later stages. The transition in surface protein composition of
adipocyte lipid droplets from ADRP to perilipins occurred 3 days after the
initiation of differentiation when cells displayed co-localizatioin of both
proteins on the same lipid droplets. The specific localization of adipose
differentiation-related protein to lipid droplets in a wide variety of
cells suggests that ADRP plays a role in management of neutral lipid
stores.

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|
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|
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|

|
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|
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48(1):
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|
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|

|
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|
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21(1):
167 - 178.
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|
 |
|

|
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|
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|
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|

|
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|
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55(12):
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|
 |
|

|
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|
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47(11):
2367 - 2373.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
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119(20):
4215 - 4224.
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[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. Ren, J. He, H. Jiang, L. Zu, S. Pu, X. Guo, and G. Xu
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37(1):
175 - 183.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. J. Gerdes, M. Myakishev, N. A. Frost, V. Rishi, J. Moitra, A. Acharya, M. R. Levy, S.-w. Park, A. Glick, S. H. Yuspa, et al.
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August 1, 2006;
66(15):
7578 - 7588.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
P. Bostrom, B. Magnusson, P.-A. Svensson, O. Wiklund, J. Boren, L. M. S. Carlsson, M. Stahlman, S.-O. Olofsson, and L. M. Hulten
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Arterioscler Thromb Vasc Biol,
August 1, 2006;
26(8):
1871 - 1876.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. L. Niklaus and J. W. Pollard
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July 1, 2006;
147(7):
3375 - 3390.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
B. Magnusson, L. Asp, P. Bostrom, M. Ruiz, P. Stillemark-Billton, D. Linden, J. Boren, and S.-O. Olofsson
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Arterioscler Thromb Vasc Biol,
July 1, 2006;
26(7):
1566 - 1571.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
L. Andersson, P. Bostrom, J. Ericson, M. Rutberg, B. Magnusson, D. Marchesan, M. Ruiz, L. Asp, P. Huang, M. A. Frohman, et al.
PLD1 and ERK2 regulate cytosolic lipid droplet formation
J. Cell Sci.,
June 1, 2006;
119(11):
2246 - 2257.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. Yamaguchi, S. Matsushita, K. Motojima, F. Hirose, and T. Osumi
MLDP, a Novel PAT Family Protein Localized to Lipid Droplets and Enriched in the Heart, Is Regulated by Peroxisome Proliferator-activated Receptor {alpha}
J. Biol. Chem.,
May 19, 2006;
281(20):
14232 - 14240.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
K. T. Dalen, S. M. Ulven, B. M. Arntsen, K. Solaas, and H. I. Nebb
PPAR{alpha} activators and fasting induce the expression of adipose differentiation-related protein in liver
J. Lipid Res.,
May 1, 2006;
47(5):
931 - 943.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Sato, M. Fukasawa, Y. Yamakawa, T. Natsume, T. Suzuki, I. Shoji, H. Aizaki, T. Miyamura, and M. Nishijima
Proteomic profiling of lipid droplet proteins in hepatoma cell lines expressing hepatitis C virus core protein.
J. Biochem.,
May 1, 2006;
139(5):
921 - 930.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Marcinkiewicz, D. Gauthier, A. Garcia, and D. L. Brasaemle
The Phosphorylation of Serine 492 of Perilipin A Directs Lipid Droplet Fragmentation and Dispersion
J. Biol. Chem.,
April 28, 2006;
281(17):
11901 - 11909.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
K. A. R. Tobin, N. K. Harsem, K. T. Dalen, A. C. Staff, H. I. Nebb, and A. K. Duttaroy
Regulation of ADRP expression by long-chain polyunsaturated fatty acids in BeWo cells, a human placental choriocarcinoma cell line
J. Lipid Res.,
April 1, 2006;
47(4):
815 - 823.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
B. H.-J. Chang, L. Li, A. Paul, S. Taniguchi, V. Nannegari, W. C. Heird, and L. Chan
Protection against Fatty Liver but Normal Adipogenesis in Mice Lacking Adipose Differentiation-Related Protein
Mol. Cell. Biol.,
February 1, 2006;
26(3):
1063 - 1076.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
U. Edvardsson, A. Ljungberg, D. Linden, L. William-Olsson, H. Peilot-Sjogren, A. Ahnmark, and J. Oscarsson
PPAR{alpha} activation increases triglyceride mass and adipose differentiation-related protein in hepatocytes
J. Lipid Res.,
February 1, 2006;
47(2):
329 - 340.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. N. Gross, H. Miyoshi, T. Hosaka, H.-H. Zhang, E. C. Pino, S. Souza, M. Obin, A. S. Greenberg, and P. F. Pilch
Dynamics of Lipid Droplet-Associated Proteins during Hormonally Stimulated Lipolysis in Engineered Adipocytes: Stabilization and Lipid Droplet Binding of Adipocyte Differentiation-Related Protein/Adipophilin
Mol. Endocrinol.,
February 1, 2006;
20(2):
459 - 466.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Y. Masuda, H. Itabe, M. Odaki, K. Hama, Y. Fujimoto, M. Mori, N. Sasabe, J. Aoki, H. Arai, and T. Takano
ADRP/adipophilin is degraded through the proteasome-dependent pathway during regression of lipid-storing cells
J. Lipid Res.,
January 1, 2006;
47(1):
87 - 98.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
V. Llorente-Cortes, M. Otero-Vinas, S. Camino-Lopez, P. Costales, and L. Badimon
Cholesteryl Esters of Aggregated LDL Are Internalized by Selective Uptake in Human Vascular Smooth Muscle Cells
Arterioscler Thromb Vasc Biol,
January 1, 2006;
26(1):
117 - 123.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. Xu, C. Sztalryd, X. Lu, J. T. Tansey, J. Gan, H. Dorward, A. R. Kimmel, and C. Londos
Post-translational Regulation of Adipose Differentiation-related Protein by the Ubiquitin/Proteasome Pathway
J. Biol. Chem.,
December 30, 2005;
280(52):
42841 - 42847.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Cinti, G. Mitchell, G. Barbatelli, I. Murano, E. Ceresi, E. Faloia, S. Wang, M. Fortier, A. S. Greenberg, and M. S. Obin
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J. Lipid Res.,
November 1, 2005;
46(11):
2347 - 2355.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
P. Wei, S. Taniguchi, Y. Sakai, M. Imamura, T. Inoguchi, H. Nawata, S. Oda, Y. Nakabeppu, J. Nishimura, and S. Ikuyama
Expression of Adipose Differentiation-Related Protein (ADRP) Is Conjointly Regulated by PU.1 and AP-1 in Macrophages
J. Biochem.,
October 1, 2005;
138(4):
399 - 412.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
P. Bostrom, M. Rutberg, J. Ericsson, P. Holmdahl, L. Andersson, M. A. Frohman, J. Boren, and S.-O. Olofsson
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Arterioscler Thromb Vasc Biol,
September 1, 2005;
25(9):
1945 - 1951.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. M. Wurfel, W. Y. Park, F. Radella, J. Ruzinski, A. Sandstrom, J. Strout, R. E. Bumgarner, and T. R. Martin
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August 15, 2005;
175(4):
2570 - 2578.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
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Arterioscler Thromb Vasc Biol,
August 1, 2005;
25(8):
1711 - 1717.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
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Lipid Droplets Gain PAT Family Proteins by Interaction with Specialized Plasma Membrane Domains
J. Biol. Chem.,
July 15, 2005;
280(28):
26330 - 26338.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
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Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane
J. Cell Sci.,
June 15, 2005;
118(12):
2601 - 2611.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
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[Full Text]
[PDF]
|
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|
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|
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|
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J. Clin. Endocrinol. Metab.,
June 1, 2005;
90(6):
3251 - 3261.
[Abstract]
[Full Text]
[PDF]
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S. E. Schadinger, N. L. R. Bucher, B. M. Schreiber, and S. R. Farmer
PPAR{gamma}2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes
Am J Physiol Endocrinol Metab,
June 1, 2005;
288(6):
E1195 - E1205.
[Abstract]
[Full Text]
[PDF]
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C. L. Seachord, C. A. VandeVoort, and D. M. Duffy
Adipose Differentiation-Related Protein: A Gonadotropin- and Prostaglandin-Regulated Protein in Primate Periovulatory Follicles
Biol Reprod,
June 1, 2005;
72(6):
1305 - 1314.
[Abstract]
[Full Text]
[PDF]
|
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N. E. Wolins, B. K. Quaynor, J. R. Skinner, M. J. Schoenfish, A. Tzekov, and P. E. Bickel
S3-12, Adipophilin, and TIP47 Package Lipid in Adipocytes
J. Biol. Chem.,
May 13, 2005;
280(19):
19146 - 19155.
[Abstract]
[Full Text]
[PDF]
|
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|
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S. Chung, J. M. Brown, M. B. Sandberg, and M. McIntosh
Trans-10,cis-12 CLA increases adipocyte lipolysis and alters lipid droplet-associated proteins: role of mTOR and ERK signaling
J. Lipid Res.,
May 1, 2005;
46(5):
885 - 895.
[Abstract]
[Full Text]
[PDF]
|
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J. W. Meadows, B. Pitzer, D. E. Brockman, and L. Myatt
Expression and Localization of Adipophilin and Perilipin in Human Fetal Membranes: Association with Lipid Bodies and Enzymes Involved in Prostaglandin Synthesis
J. Clin. Endocrinol. Metab.,
April 1, 2005;
90(4):
2344 - 2350.
[Abstract]
[Full Text]
[PDF]
|
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|
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H. Robenek, S. Lorkowski, M. Schnoor, and D. Troyer
Spatial Integration of TIP47 and Adipophilin in Macrophage Lipid Bodies
J. Biol. Chem.,
February 18, 2005;
280(7):
5789 - 5794.
[Abstract]
[Full Text]
[PDF]
|
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|
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A. J. Smith, M. A. Sanders, B. R. Thompson, C. Londos, F. B. Kraemer, and D. A. Bernlohr
Physical Association between the Adipocyte Fatty Acid-binding Protein and Hormone-sensitive Lipase: A FLUORESCENCE RESONANCE ENERGY TRANSFER ANALYSIS
J. Biol. Chem.,
December 10, 2004;
279(50):
52399 - 52405.
[Abstract]
[Full Text]
[PDF]
|
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|
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D. L. Brasaemle, G. Dolios, L. Shapiro, and R. Wang
Proteomic Analysis of Proteins Associated with Lipid Droplets of Basal and Lipolytically Stimulated 3T3-L1 Adipocytes
J. Biol. Chem.,
November 5, 2004;
279(45):
46835 - 46842.
[Abstract]
[Full Text]
[PDF]
|
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|
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|
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V. Subramanian, A. Garcia, A. Sekowski, and D. L. Brasaemle
Hydrophobic sequences target and anchor perilipin A to lipid droplets
J. Lipid Res.,
November 1, 2004;
45(11):
1983 - 1991.
[Abstract]
[Full Text]
[PDF]
|
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|
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|
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A. W. Cohen, R. Hnasko, W. Schubert, and M. P. Lisanti
Role of Caveolae and Caveolins in Health and Disease
Physiol Rev,
October 1, 2004;
84(4):
1341 - 1379.
[Abstract]
[Full Text]
[PDF]
|
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V. Subramanian, A. Rothenberg, C. Gomez, A. W. Cohen, A. Garcia, S. Bhattacharyya, L. Shapiro, G. Dolios, R. Wang, M. P. Lisanti, et al.
Perilipin A Mediates the Reversible Binding of CGI-58 to Lipid Droplets in 3T3-L1 Adipocytes
J. Biol. Chem.,
October 1, 2004;
279(40):
42062 - 42071.
[Abstract]
[Full Text]
[PDF]
|
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|
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|
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J. M. Caviglia, I. N. T. de Gomez Dumm, R. A. Coleman, and R. A. Igal
Phosphatidylcholine deficiency upregulates enzymes of triacylglycerol metabolism in CHO cells
J. Lipid Res.,
August 1, 2004;
45(8):
1500 - 1509.
[Abstract]
[Full Text]
[PDF]
|
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|

|
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|
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T. Yamaguchi, N. Omatsu, S. Matsushita, and T. Osumi
CGI-58 Interacts with Perilipin and Is Localized to Lipid Droplets: POSSIBLE INVOLVEMENT OF CGI-58 MISLOCALIZATION IN CHANARIN-DORFMAN SYNDROME
J. Biol. Chem.,
July 16, 2004;
279(29):
30490 - 30497.
[Abstract]
[Full Text]
[PDF]
|
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|

|
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|
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E. Umlauf, E. Csaszar, M. Moertelmaier, G. J. Schuetz, R. G. Parton, and R. Prohaska
Association of Stomatin with Lipid Bodies
J. Biol. Chem.,
May 28, 2004;
279(22):
23699 - 23709.
[Abstract]
[Full Text]
[PDF]
|
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|

|
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|
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S. D. Patel, M. W. Rajala, L. Rossetti, P. E. Scherer, and L. Shapiro
Disulfide-Dependent Multimeric Assembly of Resistin Family Hormones
Science,
May 21, 2004;
304(5674):
1154 - 1158.
[Abstract]
[Full Text]
[PDF]
|
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K. T. Dalen, K. Schoonjans, S. M. Ulven, M. S. Weedon-Fekjaer, T. G. Bentzen, H. Koutnikova, J. Auwerx, and H. I. Nebb
Adipose Tissue Expression of the Lipid Droplet-Associating Proteins S3-12 and Perilipin Is Controlled by Peroxisome Proliferator-Activated Receptor-{gamma}
Diabetes,
May 1, 2004;
53(5):
1243 - 1252.
[Abstract]
[Full Text]
[PDF]
|
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|
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|
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A. W. Cohen, B. Razani, W. Schubert, T. M. Williams, X. B. Wang, P. Iyengar, D. L. Brasaemle, P. E. Scherer, and M. P. Lisanti
Role of Caveolin-1 in the Modulation of Lipolysis and Lipid Droplet Formation
Diabetes,
May 1, 2004;
53(5):
1261 - 1270.
[Abstract]
[Full Text]
[PDF]
|
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|
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R. Mishra, S. N. Emancipator, C. Miller, T. Kern, and M. S. Simonson
Adipose differentiation-related protein and regulators of lipid homeostasis identified by gene expression profiling in the murine db/db diabetic kidney
Am J Physiol Renal Physiol,
May 1, 2004;
286(5):
F913 - F921.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
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|
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S. Urs, C. Smith, B. Campbell, A. M. Saxton, J. Taylor, B. Zhang, J. Snoddy, B. Jones Voy, and N. Moustaid-Moussa
Gene Expression Profiling in Human Preadipocytes and Adipocytes by Microarray Analysis
J. Nutr.,
April 1, 2004;
134(4):
762 - 770.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. Larigauderie, C. Furman, M. Jaye, C. Lasselin, C. Copin, J.-C. Fruchart, G. Castro, and M. Rouis
Adipophilin Enhances Lipid Accumulation and Prevents Lipid Efflux From THP-1 Macrophages: Potential Role in Atherogenesis
Arterioscler Thromb Vasc Biol,
March 1, 2004;
24(3):
504 - 510.
[Abstract]
[Full Text]
|
 |
|

|
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|
 |
 
A. Garcia, V. Subramanian, A. Sekowski, S. Bhattacharyya, M. W. Love, and D. L. Brasaemle
The Amino and Carboxyl Termini of Perilipin A Facilitate the Storage of Triacylglycerols
J. Biol. Chem.,
February 27, 2004;
279(9):
8409 - 8416.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
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A. G. Ostermeyer, L. T. Ramcharan, Y. Zeng, D. M. Lublin, and D. A. Brown
Role of the hydrophobic domain in targeting caveolin-1 to lipid droplets
J. Cell Biol.,
January 5, 2004;
164(1):
69 - 78.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
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|
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I. Bildirici, C.-R. Roh, W. T. Schaiff, B. M. Lewkowski, D. M. Nelson, and Y. Sadovsky
The Lipid Droplet-Associated Protein Adipophilin Is Expressed in Human Trophoblasts and Is Regulated by Peroxisomal Proliferator-Activated Receptor-{gamma}/Retinoid X Receptor
J. Clin. Endocrinol. Metab.,
December 1, 2003;
88(12):
6056 - 6062.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
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X. Nan, J.-X. Cheng, and X. S. Xie
Vibrational imaging of lipid droplets in live fibroblast cells with coherent anti-Stokes Raman scattering microscopy
J. Lipid Res.,
November 1, 2003;
44(11):
2202 - 2208.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
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|
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N. E. Wolins, J. R. Skinner, M. J. Schoenfish, A. Tzekov, K. G. Bensch, and P. E. Bickel
Adipocyte Protein S3-12 Coats Nascent Lipid Droplets
J. Biol. Chem.,
September 26, 2003;
278(39):
37713 - 37721.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Ohashi, N. Mizushima, Y. Kabeya, and T. Yoshimori
Localization of Mammalian NAD(P)H Steroid Dehydrogenase-like Protein on Lipid Droplets
J. Biol. Chem.,
September 19, 2003;
278(38):
36819 - 36829.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
O. Gavrilova, M. Haluzik, K. Matsusue, J. J. Cutson, L. Johnson, K. R. Dietz, C. J. Nicol, C. Vinson, F. J. Gonzalez, and M. L. Reitman
Liver Peroxisome Proliferator-activated Receptor {gamma} Contributes to Hepatic Steatosis, Triglyceride Clearance, and Regulation of Body Fat Mass
J. Biol. Chem.,
September 5, 2003;
278(36):
34268 - 34276.
[Abstract]
[Full Text]
[PDF]
|
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|

|
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|
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T. Hayashi and T.-P. Su
{sigma}-1 Receptors ({sigma}1 Binding Sites) Form Raft-Like Microdomains and Target Lipid Droplets on the Endoplasmic Reticulum: Roles in Endoplasmic Reticulum Lipid Compartmentalization and Export
J. Pharmacol. Exp. Ther.,
August 1, 2003;
306(2):
718 - 725.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. Hayashi and T.-P. Su
Intracellular Dynamics of {sigma}-1 Receptors ({sigma}1 Binding Sites) in NG108-15 Cells
J. Pharmacol. Exp. Ther.,
August 1, 2003;
306(2):
726 - 733.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
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|
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C. Sztalryd, G. Xu, H. Dorward, J. T. Tansey, J. A. Contreras, A. R. Kimmel, and C. Londos
Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation
J. Cell Biol.,
June 23, 2003;
161(6):
1093 - 1103.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. DiDonato and D. L. Brasaemle
Fixation Methods for the Study of Lipid Droplets by Immunofluorescence Microscopy
J. Histochem. Cytochem.,
June 1, 2003;
51(6):
773 - 780.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Rome, K. Clement, R. Rabasa-Lhoret, E. Loizon, C. Poitou, G. S. Barsh, J.-P. Riou, M. Laville, and H. Vidal
Microarray Profiling of Human Skeletal Muscle Reveals That Insulin Regulates ~800 Genes during a Hyperinsulinemic Clamp
J. Biol. Chem.,
May 9, 2003;
278(20):
18063 - 18068.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
P. Targett-Adams, D. Chambers, S. Gledhill, R. G. Hope, J. F. Coy, A. Girod, and J. McLauchlan
Live Cell Analysis and Targeting of the Lipid Droplet-binding Adipocyte Differentiation-related Protein
J. Biol. Chem.,
April 25, 2003;
278(18):
15998 - 16007.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. L. McManaman, W. Zabaronick, J. Schaack, and D. J. Orlicky
Lipid droplet targeting domains of adipophilin
J. Lipid Res.,
April 1, 2003;
44(4):
668 - 673.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. T. Tansey, A. M. Huml, R. Vogt, K. E. Davis, J. M. Jones, K. A. Fraser, D. L. Brasaemle, A. R. Kimmel, and C. Londos
Functional Studies on Native and Mutated Forms of Perilipins. A ROLE IN PROTEIN KINASE A-MEDIATED LIPOLYSIS OF TRIACYLGLYCEROLS IN CHINESE HAMSTER OVARY CELLS
J. Biol. Chem.,
February 28, 2003;
278(10):
8401 - 8406.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Imamura, T. Inoguchi, S. Ikuyama, S. Taniguchi, K. Kobayashi, N. Nakashima, and H. Nawata
ADRP stimulates lipid accumulation and lipid droplet formation in murine fibroblasts
Am J Physiol Endocrinol Metab,
October 1, 2002;
283(4):
E775 - E783.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
C. J. Schultz, E. Torres, C. Londos, and J. S. Torday
Role of adipocyte differentiation-related protein in surfactant phospholipid synthesis by type II cells
Am J Physiol Lung Cell Mol Physiol,
August 1, 2002;
283(2):
L288 - L296.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. C. Souza, K. V. Muliro, L. Liscum, P. Lien, M. T. Yamamoto, J. E. Schaffer, G. E. Dallal, X. Wang, F. B. Kraemer, M. Obin, et al.
Modulation of Hormone-sensitive Lipase and Protein Kinase A-mediated Lipolysis by Perilipin A in an Adenoviral Reconstituted System
J. Biol. Chem.,
March 1, 2002;
277(10):
8267 - 8272.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
N. B. Cole, D. D. Murphy, T. Grider, S. Rueter, D. Brasaemle, and R. L. Nussbaum
Lipid Droplet Binding and Oligomerization Properties of the Parkinson's Disease Protein alpha -Synuclein
J. Biol. Chem.,
February 15, 2002;
277(8):
6344 - 6352.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
R. G. Hope, D. J. Murphy, and J. McLauchlan
The Domains Required to Direct Core Proteins of Hepatitis C Virus and GB Virus-B to Lipid Droplets Share Common Features with Plant Oleosin Proteins
J. Biol. Chem.,
February 1, 2002;
277(6):
4261 - 4270.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. J. Charron and L. D. Sibley
Host cells: mobilizable lipid resources for the intracellular parasite Toxoplasma gondii
J. Cell Sci.,
January 8, 2002;
115(15):
3049 - 3059.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S. Cases, S. J. Stone, P. Zhou, E. Yen, B. Tow, K. D. Lardizabal, T. Voelker, and R. V. Farese Jr.
Cloning of DGAT2, a Second Mammalian Diacylglycerol Acyltransferase, and Related Family Members
J. Biol. Chem.,
October 12, 2001;
276(42):
38870 - 38876.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
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|
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J. T. Tansey, C. Sztalryd, J. Gruia-Gray, D. L. Roush, J. V. Zee, O. Gavrilova, M. L. Reitman, C.-X. Deng, C. Li, A. R. Kimmel, et al.
Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity
PNAS,
May 22, 2001;
98(11):
6494 - 6499.
[Abstract]
[Full Text]
[PDF]
|
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Copyright © 1997 by the American Society for Biochemistry and Molecular Biology.
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