HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sbarbati, A. Articles by Osculati, F. Search for Related Content PubMed PubMed Citation Articles by Sbarbati, A. Articles by Osculati, F. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol 38, 343-347, Copyright © 1997 by Lipid Research, Inc.

ARTICLES

Chemical shift imaging at 4.7 tesla of brown adipose tissue

A Sbarbati, U Guerrini, P Marzola, R Asperio and F Osculati
Institute of Anatomy and Histology, University of Verona, Italy.

In vivo distinction between small deposits of brown adipose tissue (BAT) and surrounding tissues may be difficult. In this article, we propose an experiment paradigm, based on techniques of chemical shift magnetic resonance imaging (CSI), which can improve the methods presently available for the study of BAT. Male rats were examined in an imager-spectrometer equipped with a 4.7 T magnet. Proton spectra of isolated BAT deposits showed that both fat and water protons contributed significantly to the genesis of the magnetic resonance signal. An equivocal definition of BAT deposits was obtained by three (respectively, spin-echo, water-selective, and fat-selective) images. The spin-echo (SE), T1-weighted image provided the best anatomical description of the structures. The images selective for fat-protons displayed the degree of lipid accumulation in each area. The images selective for water-protons provided an internal control of adipose tissue localization. The proposed paradigm allows an unequivocal definition of BAT deposits and appears particularly useful in studies where experimental manipulation (i.e., cold acclimation or drug treatment) produces changes in this issue.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				E. Lunati, P. Marzola, E. Nicolato, M. Fedrigo, M. Villa, and A. Sbarbati In vivo quantitative lipidic map of brown adipose tissue by chemical shift imaging at 4.7 tesla J. Lipid Res., August 1, 1999; 40(8): 1395 - 1400. [Abstract] [Full Text]