| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Lipid Research, Vol 38, 419-428, Copyright © 1997 by Lipid Research, Inc.
ARTICLES |
A Sevanian, G Bittolo-Bon, G Cazzolato, H Hodis, J Hwang, A Zamburlini, M Maiorino and F Ursini
Department of Molecular Pharmacology and Toxicology, University of Southern California, School of Pharmcy, Los Angeles 90033, USA.
A subclass of LDL described on the basis of its greater electronegativity and oxidative status is further characterized using a new, highly sensitive single photon counting technique to measure lipid hydroperoxides. We describe in this report that these particles, which we refer to as LDL-, are enriched in lipid peroxides and other peroxidation products as compared to the bulk of the unmodified, normal LDL (nLDL) recovered from human plasma. This chemiluminescence-based, single photon counting technique has unique advantages in that analyses are performed on whole LDL, thus avoiding artifactual lipid peroxidation during lipid extraction. Evidence for increased amounts of lipid hydroperoxides in LDL- versus nLDL are in agreement with other analytical methods such as measurement of conjugated dienes as well as cholesterol oxidation products. LDL- also has lower proportions of polyunsaturated fatty acids than nLDL. Analysis of the amino acid composition of apoB-100 and fatty acid composition of total LDL lipids also revealed major differences between nLDL and LDL- consistent with an oxidative modification of the latter. Thus, LDL- has significantly lower proportions of the oxidizable amino acids histidine and lysine, and marked differences in other neutral and acidic amino acids. The deficit in specific amino acids is in agreement with a reduced TNBS reactivity and increased relative electrophoretic mobility of LDL-. We postulate that LDL- is a major carrier of lipid hydroperoxides associated with plasma LDL and may arise from oxidative events in the vasculature and/ or by ingestion of peroxide-enriched meals.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  K. Chen, M. Febbraio, W. Li, and R. L. Silverstein A Specific CD36-Dependent Signaling Pathway Is Required for Platelet Activation by Oxidized Low-Density Lipoprotein Circ. Res., June 20, 2008; 102(12): 1512 - 1519. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kanayama, S. Yamaguchi, T. Shibata, N. Shibata, M. Kobayashi, R. Nagai, H. Arai, K. Takahashi, and K. Uchida Identification of a Serum Component That Regulates Cyclooxygenase-2 Gene Expression in Cooperation with 4-Hydroxy-2-nonenal J. Biol. Chem., August 17, 2007; 282(33): 24166 - 24174. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. G. Tsouli, D. N. Kiortsis, V. Xydis, M. I. Argyropoulou, M. Elisaf, and A. D. Tselepis Antibodies against various forms of mildly oxidized low-density lipoprotein are not associated with carotid intima-media thickness in patients with primary hyperlipidemia. Angiology, October 1, 2006; 57(5): 615 - 622. [Abstract] [PDF]
|
|
|
|
 |
|
 J. P. Conway and M. Kinter Proteomic and Transcriptomic Analyses of Macrophages with an Increased Resistance to Oxidized Low Density Lipoprotein (oxLDL)-induced Cytotoxicity Generated by Chronic Exposure to oxLDL Mol. Cell. Proteomics, October 1, 2005; 4(10): 1522 - 1540. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Zalewski and C. Macphee Role of Lipoprotein-Associated Phospholipase A2 in Atherosclerosis: Biology, Epidemiology, and Possible Therapeutic Target Arterioscler. Thromb. Vasc. Biol., May 1, 2005; 25(5): 923 - 931. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Asatryan, R. T. Hamilton, J. M. Isas, J. Hwang, R. Kayed, and A. Sevanian LDL phospholipid hydrolysis produces modified electronegative particles with an unfolded apoB-100 protein J. Lipid Res., January 1, 2005; 46(1): 115 - 122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-L. Liu, K. Ylitalo, R. Salonen, J. T. Salonen, and M.-R. Taskinen Circulating Oxidized Low-Density Lipoprotein and Its Association With Carotid Intima-Media Thickness in Asymptomatic Members of Familial Combined Hyperlipidemia Families Arterioscler. Thromb. Vasc. Biol., August 1, 2004; 24(8): 1492 - 1497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Navab, G. M. Ananthramaiah, S. T. Reddy, B. J. Van Lenten, B. J. Ansell, G. C. Fonarow, K. Vahabzadeh, S. Hama, G. Hough, N. Kamranpour, et al. Thematic review series: The Pathogenesis of Atherosclerosis The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL J. Lipid Res., June 1, 2004; 45(6): 993 - 1007. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Haseruck, W. Erl, D. Pandey, G. Tigyi, P. Ohlmann, C. Ravanat, C. Gachet, and W. Siess The plaque lipid lysophosphatidic acid stimulates platelet activation and platelet-monocyte aggregate formation in whole blood: involvement of P2Y1 and P2Y12 receptors Blood, April 1, 2004; 103(7): 2585 - 2592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hwang, M. H. Ing, A. Salazar, B. Lassegue, K. Griendling, M. Navab, A. Sevanian, and T. K. Hsiai Pulsatile Versus Oscillatory Shear Stress Regulates NADPH Oxidase Subunit Expression: Implication for Native LDL Oxidation Circ. Res., December 12, 2003; 93(12): 1225 - 1232. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Rother, R. Brandl, D. L. Baker, P. Goyal, H. Gebhard, G. Tigyi, and W. Siess Subtype-Selective Antagonists of Lysophosphatidic Acid Receptors Inhibit Platelet Activation Triggered by the Lipid Core of Atherosclerotic Plaques Circulation, August 12, 2003; 108(6): 741 - 747. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Benitez, J. L. Sanchez-Quesada, V. Ribas, O. Jorba, F. Blanco-Vaca, F. Gonzalez-Sastre, and J. Ordonez-Llanos Platelet-Activating Factor Acetylhydrolase Is Mainly Associated With Electronegative Low-Density Lipoprotein Subfraction Circulation, July 8, 2003; 108(1): 92 - 96. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-y. Yang, J. L. Raya, H.-H. Chen, C.-H. Chen, Y. Abe, H. J. Pownall, A. A. Taylor, and C. V. Smith Isolation, Characterization, and Functional Assessment of Oxidatively Modified Subfractions of Circulating Low-Density Lipoproteins Arterioscler. Thromb. Vasc. Biol., June 1, 2003; 23(6): 1083 - 1090. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-H. Chen, T. Jiang, J.-H. Yang, W. Jiang, J. Lu, G. K. Marathe, H. J. Pownall, C. M. Ballantyne, T. M. McIntyre, P. D. Henry, et al. Low-Density Lipoprotein in Hypercholesterolemic Human Plasma Induces Vascular Endothelial Cell Apoptosis by Inhibiting Fibroblast Growth Factor 2 Transcription Circulation, April 29, 2003; 107(16): 2102 - 2108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Maeba and N. Ueta Ethanolamine plasmalogens prevent the oxidation of cholesterol by reducing the oxidizability of cholesterol in phospholipid bilayers J. Lipid Res., January 1, 2003; 44(1): 164 - 171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Sanchez-Quesada, S. Benitez, C. Otal, M. Franco, F. Blanco-Vaca, and J. Ordonez-Llanos Density distribution of electronegative LDL in normolipemic and hyperlipemic subjects J. Lipid Res., May 1, 2002; 43(5): 699 - 705. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. URSINI and A. SEVANIAN Wine Polyphenols and Optimal Nutrition Ann. N.Y. Acad. Sci., May 1, 2002; 957(1): 200 - 209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Plat, H. Brzezinka, D. Lutjohann, R. P. Mensink, and K. von Bergmann Oxidized plant sterols in human serum and lipid infusions as measured by combined gas-liquid chromatography-mass spectrometry J. Lipid Res., December 1, 2001; 42(12): 2030 - 2038. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Sanchez-Quesada, A. Perez, A. Caixas, M. Rigla, A. Payes, S. Benitez, and J. Ordonez-Llanos Effect of Glycemic Optimization on Electronegative Low-Density Lipoprotein in Diabetes: Relation to Nonenzymatic Glycosylation and Oxidative Modification J. Clin. Endocrinol. Metab., July 1, 2001; 86(7): 3243 - 3249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Navab, J. A. Berliner, G. Subbanagounder, S. Hama, A. J. Lusis, L. W. Castellani, S. Reddy, D. Shih, W. Shi, A. D. Watson, et al. HDL and the Inflammatory Response Induced by LDL-Derived Oxidized Phospholipids Arterioscler. Thromb. Vasc. Biol., April 1, 2001; 21(4): 481 - 488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Conxita De Castellarnau, J. L. Sanchez-Quesada, S. Benitez, R. Rosa, L. Caveda, L. Vila, and J. Ordonez-Llanos Electronegative LDL From Normolipemic Subjects Induces IL-8 and Monocyte Chemotactic Protein Secretion by Human Endothelial Cells Arterioscler. Thromb. Vasc. Biol., October 1, 2000; 20(10): 2281 - 2287. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Navab, S. Y. Hama, C. J. Cooke, G. M. Anantharamaiah, M. Chaddha, L. Jin, G. Subbanagounder, K. F. Faull, S. T. Reddy, N. E. Miller, et al. Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: step 1 J. Lipid Res., September 1, 2000; 41(9): 1481 - 1494. [Abstract] [Full Text]
|
|
|
|
|
|
P. Pauletto, M. Puato, E. Faggin, N. Santipolo, V. Pagliara, M. Zoleo, G. P. Deriu, F. Grego, M. Plebani, S. Sartore, et al. Specific Cellular Features of Atheroma Associated With Development of Neointima After Carotid Endarterectomy : The Carotid Atherosclerosis and Restenosis Study Circulation, August 15, 2000; 102(7): 771 - 778. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. J. Schroepfer Jr. Oxysterols: Modulators of Cholesterol Metabolism and Other Processes Physiol Rev, January 1, 2000; 80(1): 361 - 554. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. X. Rong, L. Shen, Y. H. Chang, A. Richters, H. N. Hodis, and A. Sevanian Cholesterol Oxidation Products Induce Vascular Foam Cell Lesion Formation in Hypercholesterolemic New Zealand White Rabbits Arterioscler. Thromb. Vasc. Biol., September 1, 1999; 19(9): 2179 - 2188. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Ziouzenkova, L. Asatryan, M. Akmal, C. Tetta, M. L. Wratten, G. Loseto-Wich, G. Jurgens, J. Heinecke, and A. Sevanian Oxidative Cross-linking of ApoB100 and Hemoglobin Results in Low Density Lipoprotein Modification in Blood. RELEVANCE TO ATHEROGENESIS CAUSED BY HEMODIALYSIS J. Biol. Chem., July 2, 1999; 274(27): 18916 - 18924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Bielicki and T. M. Forte Evidence that lipid hydroperoxides inhibit plasma lecithin:cholesterol acyltransferase activity J. Lipid Res., May 1, 1999; 40(5): 948 - 954. [Abstract] [Full Text]
|
|
|
|
|
|
S. Jimi, N. Uesugi, K. Saku, H. Itabe, B. Zhang, K. Arakawa, and S. Takebayashi Possible Induction of Renal Dysfunction in Patients With Lecithin:Cholesterol Acyltransferase Deficiency by Oxidized Phosphatidylcholine in Glomeruli Arterioscler. Thromb. Vasc. Biol., March 1, 1999; 19(3): 794 - 801. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Bittolo-Bon and G. Cazzolato Analytical capillary isotachophoresis of total plasma lipoproteins: a new tool to identify atherogenic low density lipoproteins J. Lipid Res., January 1, 1999; 40(1): 170 - 177. [Abstract] [Full Text]
|
|
|
|
|
|
R. Shern-Brewer, N. Santanam, C. Wetzstein, J. White-Welkley, and S. Parthasarathy Exercise and Cardiovascular Disease : A New Perspective Arterioscler. Thromb. Vasc. Biol., July 1, 1998; 18(7): 1181 - 1187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Maschberger, M. Bauer, J. Baumann-Siemons, K. J. Zangl, E. V. Negrescu, A. J. Reininger, and W. Siess Mildly Oxidized Low Density Lipoprotein Rapidly Stimulates via Activation of the Lysophosphatidic Acid Receptor Src Family and Syk Tyrosine Kinases and Ca2+ Influx in Human Platelets J. Biol. Chem., June 16, 2000; 275(25): 19159 - 19166. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |
