HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Daggy, B. P. Articles by Setchell, K. D. Search for Related Content PubMed PubMed Citation Articles by Daggy, B. P. Articles by Setchell, K. D. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol 38, 491-502, Copyright © 1997 by Lipid Research, Inc.

ARTICLES

Additive hypocholesterolemic effect of psyllium and cholestyramine in the hamster: influence on fecal sterol and bile acid profiles

BP Daggy, NC O'Connell, GR Jerdack, BA Stinson and KD Setchell
Procter & Gamble Company, Cincinnati, OH 45040, USA.

Recent findings suggest that the effects of cholestyramine and psyllium in combination could be additive for cholesterol-lowering. We therefore examined the effect of both agents, alone and in combination, on lipoprotein cholesterol and neutral and acidic steroid excretion in the hamster. Animals (n = 8/group) were fed for 21 days, either a basal chow diet supplemented with 10% palm oil and 0.2% cholesterol, or one of four treatments consisting of the basal diet plus: 5.5% cellulose; 5% psyllium with 0.5% cellulose; 0.5% cholestyramine with 5% cellulose; or 5% psyllium with 0.5% cholestyramine. Psyllium and cholestyramine both had significant hypocholesterolemic effects, but in combination produced additive reductions in lipoprotein and hepatic cholesterol. Psyllium, cholestyramine, and the combination increased total bile acid excretion by 26%, 57%, and 79%, respectively. Psyllium affected only unconjugated bile acid excretion while cholestyramine also increased the excretion of conjugated and primary bile acids. Neither agent, nor the combination, affected fecal neutral sterol excretion. We conclude that, while both agents lower cholesterol by a mechanism of increased bile acid excretion, these studies indicate that psyllium does not bind bile acids in vivo and lend further support for the concomitant use of these agents for cholesterol-lowering.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				S.-O. Lee, A. L. Simons, P. A. Murphy, and S. Hendrich Soyasaponins Lowered Plasma Cholesterol and Increased Fecal Bile Acids in Female Golden Syrian Hamsters Exp Biol Med, July 1, 2005; 230(7): 472 - 478. [Abstract] [Full Text] [PDF]

				E. A. Trautwein, A. Kunath-Rau, and H. F. Erbersdobler Increased Fecal Bile Acid Excretion and Changes in the Circulating Bile Acid Pool Are Involved in the Hypocholesterolemic and Gallstone-Preventive Actions of Psyllium in Hamsters J. Nutr., April 1, 1999; 129(4): 896 - 902. [Abstract] [Full Text]

				A.H.M. Terpstra, J. A. Lapre, H. T. de Vries, and A. C. Beynen Dietary Pectin with High Viscosity Lowers Plasma and Liver Cholesterol Concentration and Plasma Cholesteryl Ester Transfer Protein Activity in Hamsters J. Nutr., November 1, 1998; 128(11): 1944 - 1949. [Abstract] [Full Text]