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Journal of Lipid Research, Vol 38, 680-689, Copyright © 1997 by Lipid Research, Inc.
S Delion, S Chalon, D Guilloteau, B Lejeune, JC Besnard and G Durand
The influence of aging (2, 6, 12, and 24 months) on hippocampal lipid
composition and neurochemical markers (endogenous noradrenaline, serotonin
levels, monoamine oxidase (MOA) activities) was studied in rats fed a
control or an n-3 polyunsaturated fatty acid (PUFA)- deficient diet. The
n-3 PUFA deficiency reduced the 22:6 (n-3) level, compensated by the
increase in 22:5 (n-6). However, the difference in 22:6 (n-3) content
between control and deficient rats was less between 2 and 12 months and
then became stable. There was an overall age- induced decrease in the major
phospholipid classes phosphatidylethanolamine (PE), and phosphatidylcholine
(PC) whereas the minor classes, phosphatidylinositol (PI),
phosphatidylserine (PS), and sphingomyelin (SM), were greatly increased,
regardless of diet. The n-3 PUFA deficiency induced a reduction in the PS
level, concomitant with a higher level in MAO-B activity as compared to
control rats at the age of 24 months. The age-related evolution of the
MAO-B activity was parallel with that of noradrenaline levels in both
dietary groups. The noradrenaline and serotonin levels were modified
according to age but without effect of the n-3 PUFA deficiency. Results
showed that the hippocampus sustained specific age-induced modifications in
lipid composition and neurotransmission factors, often with a transition
period between 6 and 12 months.
ARTICLES
Age-related changes in phospholipid fatty acid composition and monoaminergic neurotransmission in the hippocampus of rats fed a balanced or an n-3 polyunsaturated fatty acid-deficient diet
INSERM U316, Laboratoire de Biophysique Medicale et Pharmaceutique, Tours, France.
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