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Journal of Lipid Research, Vol 38, 795-804, Copyright © 1997 by Lipid Research, Inc.
Variation in adrenergic regulation of lipolysis between omental and subcutaneous adipocytes from obese and non-obese men
J Hoffstedt, P Arner, G Hellers and F Lonnqvist
Department of Medicine and Surgery, Huddinge University Hospital, Sweden.
Regional variations in adipocyte lipolysis between subcutaneous and
visceral fat may be important for obesity complications. In the present
study, we compared adrenergic regulation of lipolysis in omental and
subcutaneous adipocytes from obese (n = 15) and non-obese (n = 14) male
subjects. Waist-to-hip ratio, blood pressure, plasma insulin, and plasma
triglycerides were increased in obesity. No regional differences in
adrenoceptor lipolytic function were observed in non-obese subjects with
the exception of a slight increase in noradrenaline sensitivity in omental
adipocytes (P < 0.05), because of increased beta(1)- adrenoceptor
sensitivity (P < 0.05). In the obese subjects, the rate of
noradrenaline-induced glycerol release was 2-fold higher (P < 0.005) and
the noradrenaline sensitivity was 3-fold higher (P < 0.05) in omental
versus subcutaneous adipocytes. These findings were mainly due to a 50-fold
increase in omental beta(3)-adrenoceptor sensitivity (P < 0.002) and to
a smaller 6-fold increase in omental beta(1)-adrenoceptor sensitivity (P
< 0.02), accompanied by increased beta(3)- as well as
beta(1)-adrenoceptor lipolytic rates at approximately 50% receptor subtype
occupancy by the agonist (P < 0.05). In conclusion, minor regional
differences in adipocyte lipolytic response to catecholamines are present
in non-obese males. In contrast, catecholamine-induced lipolysis is
markedly increased in omental as compared to subcutaneous adipocytes in
obese males, mainly due to an increase in beta(3)- adrenoceptor function of
visceral fat cells, in combination with a smaller increase in
beta(1)-adrenoceptor function.

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Copyright © 1997 by the American Society for Biochemistry and Molecular Biology.
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