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Journal of Lipid Research, Vol 38, 1421-1432, Copyright © 1997 by Lipid Research, Inc.
A Fredenrich, LM Giroux, M Tremblay, L Krimbou, J Davignon and JS Cohn
In order to assess the relationship between plasma accumulation of
triglyceride-rich lipoproteins (TRL) and lipoprotein levels of apoC-III and
apoE, we have measured apoC-III and apoE in lipoproteins separated
according to size (by automated gel filtration chromatography) from plasma
of normolipidemic subjects (plasma triglyceride (TG): 0.84 +/- 0.10 mmol/l;
mean +/- SE, n = 8), and from type III (n = 8) and type IV (n = 8)
hyperlipoproteinemic patients, matched for plasma TG (5.76 +/- 0.62 v 5.55
+/- 0.45 mmol/l, resp.). Total plasma apoC-III concentration was similar in
type III and type IV patients (33.1 +/- 3.4 v 37.6 +/- 4.4 mg/dl,
respectively), but was significantly increased compared to normolipidemic
controls (10.0 +/- 1.0 mg/dl, P < 0.001). TRL apoC-III was lower and
high density lipoprotein (HDL) apoC- III was significantly higher in type
III versus type IV subjects (14.8 +/- 3.2 vs. 22.8 +/- 3.0 mg/dl, P <
0.05; 8.3 +/- 1.0 vs. 5.2 +/- 0.5 mg/dl, P < 0.05). Plasma concentration
of apoC-III in lipoproteins that eluted between TRL and HDL
(intermediate-sized lipoproteins, ISL) was similar in the two
hypertriglyceridemic groups (10.1 +/- 1.3 vs. 9.7 +/- 1.6 mg/dl), but was
significantly higher (P< 0.05) than controls (2.2 +/- 0.3 mg/dl). TRL,
ISL, and HDL apoE concentrations were significantly higher in type III
versus type IV subjects (P < 0.05). All lipoprotein fractions in type
III patients were characterized by lower apoC-III to apoE ratios. In
contrast, the TRL apoC-III to apoE ratio of type IV patients was similar
and the ISL apoC-III to apoE ratio was significantly higher, compared to
normolipidemic individuals. These results indicate that compared to
normolipidemic individuals, remnant-like lipoproteins in the ISL fraction
of type IV patients are enriched in apoC-III relative to apoE, whereas
those of type III patients are enriched in apoE relative to apoC-III.
ARTICLES
Plasma lipoprotein distribution of apoC-III in normolipidemic and hypertriglyceridemic subjects: comparison of the apoC-III to apoE ratio in different lipoprotein fractions
Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Quebec, Canada.
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