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Journal of Lipid Research, Vol 38, 1490-1495, Copyright © 1997 by Lipid Research, Inc.
NR Webb, WJ de Villiers, PM Connell, FC de Beer and DR van der Westhuyzen
The class B, type I scavenger receptor has been implicated as a receptor
for high density lipoprotein (HDL). We have isolated a murine cDNA clone
encoding an alternative form of SR-BI that differs in the putative
cytoplasmic domain of the receptor. This variant form, likely the result of
alternative mRNA splicing, is designated SR-BI.2. SR-BI.2 mRNA was detected
in mouse tissues known to express SR-BI and tissue- specific differences in
the relative abundance of SR-BI.2 were apparent. In mouse adrenal glands,
SR-BI.2 represented approximately one-third of total SR-BI mRNA, whereas in
mouse testes, SR-BI.2 represented the major mRNA species (79% of total).
SR-BI.2 was also detected in the human cell lines examined, namely HeLa,
HepG2, and THP- 1 cells. CHO cells transfected with the mouse SR-BI.2 cDNA
expressed significant levels of SR-BI.2 protein and acquired the ability to
take up fluorescent lipid (DiI) from DiI-HDL. Alternative splicing of SR-BI
represents a potentially important process for the regulation of SR-BI
expression and function.
ARTICLES
Alternative forms of the scavenger receptor BI (SR-BI)
Department of Internal Medicine, University of Kentucky Medical Center, Lexington 40536, USA.
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