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Correspondence to:
Jonathan C. Cohen.
Plasma high density lipoprotein cholesterol (HDL-C) concentrations are higher in African American men than in white men, but the mechanism(s) responsible for this ethnic difference has not been elucidated. This study examined the relationship between hepatic lipase activity, plasma HDL-C concentrations, and a hepatic lipase polymorphism (-514T) in African American and white American men. Consistent with previous reports, plasma HDL-C concentrations were significantly higher in African American men than in white American men. Mean post-heparin plasma hepatic lipase activity was significantly lower in African American than in white American men (27 ± 12 vs. 44 ± 17 mmol · h-1 · l-1, P < 0.001). The -514T hepatic lipase allele was associated with low hepatic lipase activity in both populations, and was 3-fold more common among African Americans than white Americans.
Taken together, these data suggest that genetic differences in hepatic lipase activity contribute to the differences in plasma HDL-C concentrations between African American men and white American men.—Vega, G. L., L. T. Clark, A. Tang, S. Marcovina, S. M. Grundy, and J. C. Cohen. Hepatic lipase activity is lower in African American men than in white American men: effects of 5' flanking polymorphism in the hepatic lipase gene (LIPC). J. Lipid Res. 1998. 39: 228–232.
Supplementary key words:
high density lipoprotein cholesterol
Copyright © 1998 by Lipid Research, Inc.
Rapid Communication
Hepatic lipase activity is lower in African American men than in white American men: effects of 5' flanking polymorphism in the hepatic lipase gene (LIPC)
Gloria Lena Vegaa,
Luther T. Clarkb,
Aylmer Tangb,
Santica Marcovinac,
Scott M. Grundya, and
Jonathan C. Cohena
a The Center for Human Nutrition, Departments of Clinical Nutrition and Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75235-9052
b The State University of New York Health Science Center at Brooklyn, Brooklyn, NY 11203
c Department of Medicine and Northwest Lipid Research Laboratories, The University of Washington, Seattle, WA 98103
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L. Nie, S. Niu, G. L. Vega, L. T. Clark, A. Tang, S. M. Grundy, and J. C. Cohen Three polymorphisms associated with low hepatic lipase activity are common in African Americans J. Lipid Res., September 1, 1998; 39(9): 1900 - 1903. [Abstract] [Full Text]
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G. L. Vega, J. Gao, T. P. Bersot, R. W. Mahley, R. Verstraete, S. M. Grundy, A. White, and J. C. Cohen The -514 polymorphism in the hepatic lipase gene (LIPC) does not influence androgen-mediated stimulation of hepatic lipase activity J. Lipid Res., July 1, 1998; 39(7): 1520 - 1524. [Abstract] [Full Text]
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L. Nie, J. Wang, L. T. Clark, A. Tang, G. L. Vega, S. M. Grundy, and J. C. Cohen Body mass index and hepatic lipase gene (LIPC) polymorphism jointly influence postheparin plasma hepatic lipase activity J. Lipid Res., May 1, 1998; 39(5): 1127 - 1130. [Abstract] [Full Text] [PDF]
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M.C. Carr, A.F. Ayyobi, S.J. Murdoch, S.S. Deeb, and J.D. Brunzell Contribution of Hepatic Lipase, Lipoprotein Lipase, and Cholesteryl Ester Transfer Protein to LDL and HDL Heterogeneity in Healthy Women Arterioscler Thromb Vasc Biol, April 1, 2002; 22(4): 667 - 673. [Abstract] [Full Text] [PDF]
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