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Correspondence to: Robert J. Nicolosi.
Although comparative studies of the cholesterolemic properties of trans fatty acids relative to cis -unsaturates and saturates have been conducted in humans and animals, there is no recent information relating these lipid responses to susceptibility to atherosclerosis. Therefore, hamsters were fed diets containing equivalent amounts of cholesterol (0.12% wt/wt) and test fats (20% wt/wt) for 8 weeks. Each test fat contained between 50–52% of the total triacylglycerols as a single fatty acid, i.e., 8:0, 14:0, 18:0, cis -18:1, or trans -18:1 while the balance consisted of 16:0, cis -18:1 and 18:2 that were the same for all groups. Plasma total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-C) levels were not different for 8:0, cis -18:1, and trans -18:1, whereas 14:0 caused a significant rise in plasma TC, LDL-C, and HDL-C. LDL oxidation measurements showed that the lag phase of conjugated diene formation was longest for the trans -18:1 and cis -18:1 groups while rate of conjugated diene formation was lowest for the trans -18:1 and cis -18:1 groups. The trans -18:1- and cis -18:1-fed animals had significantly higher levels of LDL 
-tocopherol relative to the 8:0- and 14:0-fed animals. Aortic fatty streak formation was highest for the 14:0- and 8:0-fed animals and lowest for the trans -18:1.
In conclusion, the plasma lipid and antioxidant properties of trans -18:1 and cis -18:1 were comparable while the trans -18:1-fed hamsters had the least amount of early atherosclerosis. In addition, 8:0-fed animals unexpectedly had early atherosclerosis formation similar to the 14:0-fed animals.—Nicolosi, R. J., T. A. Wilson, E. J. Rogers, and D. Kritchevsky. Effects of specific fatty acids (8:0, 14:0, cis -18:1, trans -18:1) on plasma lipoproteins, early atherogenic potential, and LDL oxidative properties in the hamster. J. Lipid Res. 1998. 39: 1972–1980.
Supplementary key words:
cis oleate, trans oleate, medium chain triacylglycerols, -tocopherol, LDL oxidation, hamsters
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