HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sehayek, E. Articles by Breslow, J. L. Search for Related Content PubMed PubMed Citation Articles by Sehayek, E. Articles by Breslow, J. L. Social Bookmarking                      What's this?

The Journal of Lipid Research, Vol. 39, 2415-2422, December 1998
Copyright © 1998 by Lipid Research, Inc.

Original Article

U-shape relationship between change in dietary cholesterol absorption and plasma lipoprotein responsiveness and evidence for extreme interindividual variation in dietary cholesterol absorption in humans

Correspondence to: Jan L. Breslow.

A possible relationship between change in dietary cholesterol absorption and plasma lipoprotein responsiveness was examined in 18 normal subjects fed low fat low cholesterol, high fat low cholesterol, and high fat high cholesterol diets. For the group, neither dietary cholesterol nor dietary fat affected the percentage dietary cholesterol absorption, whereas dietary cholesterol intake raised total and LDL-C and dietary fat raised total, LDL, and HDL-C. On a fixed diet there was approximately a 2-fold variation among subjects in percentage dietary cholesterol absorption. Subjects also varied in response to dietary cholesterol and fat with regard to dietary cholesterol absorption and plasma lipoprotein responsiveness. There was a U-shaped parabolic relationship between dietary cholesterol-induced percent change in LDL-C and the change in percentage dietary cholesterol absorption (R² = 0.62, P = 0.005). A similar but weaker relationship characterized the responsiveness of HDL-C (R² = 0.38, P = 0.05). For the group, increased cholesterol intake raised dietary cholesterol mass absorption from 1.6 to 4.6 mg/kg per day, but the range of increase was from 1 to 4.7 mg/kg per day. Increased fat intake also affected dietary cholesterol mass absorption with most subjects displaying a strong inverse relationship between fat intake and mass absorption (r = -0.77, P < 0.003).

In summary: i) the percentage change in dietary cholesterol absorption in response to dietary cholesterol does appear to regulate diet responsiveness of LDL and HDL-C, and ii) the large variability in percent absorption and changes in percentage and mass absorption in response to dietary cholesterol suggest the presence of genetically determined differences among individuals in the regulation of dietary cholesterol absorption.—Sehayek, E., C. Nath, T. Heinemann, M. McGee, C. E. Seidman, P. Samuel, and J. L. Breslow. U-shape relationship between change in dietary cholesterol absorption and plasma lipoprotein responsiveness and evidence for extreme interindividual variation in dietary cholesterol absorption in humans. J. Lipid Res. 1998. 39: 2415–2422.

Supplementary key words: dietary fat, LDL, HDL

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				B. Hansel, C. Nicolle, F. Lalanne, F. Tondu, T. Lassel, Y. Donazzolo, J. Ferrieres, M. Krempf, J.-L. Schlienger, B. Verges, et al. Effect of low-fat, fermented milk enriched with plant sterols on serum lipid profile and oxidative stress in moderate hypercholesterolemia Am. J. Clinical Nutrition, September 1, 2007; 86(3): 790 - 796. [Abstract] [Full Text] [PDF]

				A. L. Garcia-Otin, M. Cofan, M. Junyent, D. Recalde, A. Cenarro, M. Pocovi, E. Ros, and F. Civeira Increased Intestinal Cholesterol Absorption in Autosomal Dominant Hypercholesterolemia and No Mutations in the Low-Density Lipoprotein Receptor or Apolipoprotein B Genes J. Clin. Endocrinol. Metab., September 1, 2007; 92(9): 3667 - 3673. [Abstract] [Full Text] [PDF]

				E. Sehayek, Y. Y. Fung, H. J. Yu, J. Lembcke, U. Ceglarek, D. Teupser, J. Thiery, D. Lutjohann, K. von Bergmann, and J. L. Breslow A complex plasma plant sterol locus on mouse chromosome 14 has at least two genes regulating intestinal sterol absorption J. Lipid Res., October 1, 2006; 47(10): 2291 - 2296. [Abstract] [Full Text] [PDF]

				J. J. Repa, S. D. Turley, G. Quan, and J. M. Dietschy Delineation of molecular changes in intrahepatic cholesterol metabolism resulting from diminished cholesterol absorption J. Lipid Res., April 1, 2005; 46(4): 779 - 789. [Abstract] [Full Text] [PDF]

				L.-P. Duan, H. H. Wang, and D. Q-H. Wang Cholesterol absorption is mainly regulated by the jejunal and ileal ATP-binding cassette sterol efflux transporters Abcg5 and Abcg8 in mice J. Lipid Res., July 1, 2004; 45(7): 1312 - 1323. [Abstract] [Full Text] [PDF]

				R. J. Kirby, P. N. Howles, and D. Y. Hui Rate of gastric emptying influences dietary cholesterol absorption efficiency in selected inbred strains of mice J. Lipid Res., January 1, 2004; 45(1): 89 - 98. [Abstract] [Full Text] [PDF]

				E. Sehayek Genetic regulation of cholesterol absorption and plasma plant sterol levels: commonalities and differences J. Lipid Res., November 1, 2003; 44(11): 2030 - 2038. [Abstract] [Full Text] [PDF]

				L. Berglund and D. Hyson Cholesterol Absorption and the Metabolic Syndrome: A New Look at an Old Area Arterioscler. Thromb. Vasc. Biol., August 1, 2003; 23(8): 1314 - 1316. [Full Text] [PDF]

				K. L. Herron, S. Vega-Lopez, K. Conde, T. Ramjiganesh, N. S. Shachter, and M. L. Fernandez Men Classified as Hypo- or Hyperresponders to Dietary Cholesterol Feeding Exhibit Differences in Lipoprotein Metabolism J. Nutr., April 1, 2003; 133(4): 1036 - 1042. [Abstract] [Full Text] [PDF]

				K. von Bergmann, D. Lutjohann, B. Lindenthal, and A. Steinmetz Efficiency of intestinal cholesterol absorption in humans is not related to apoE phenotype J. Lipid Res., January 1, 2003; 44(1): 193 - 197. [Abstract] [Full Text] [PDF]

				M. J. Sharman, W. J. Kraemer, D. M. Love, N. G. Avery, A. L. Gomez, T. P. Scheett, and J. S. Volek A Ketogenic Diet Favorably Affects Serum Biomarkers for Cardiovascular Disease in Normal-Weight Men J. Nutr., July 1, 2002; 132(7): 1879 - 1885. [Abstract] [Full Text] [PDF]

				K. L. Herron, S. Vega-Lopez, K. Conde, T. Ramjiganesh, S. Roy, N. S. Shachter, and M. L. Fernandez Pre-Menopausal Women, Classified as Hypo- or Hyper-Responders, do not Alter their LDL/HDL Ratio Following a High Dietary Cholesterol Challenge J. Am. Coll. Nutr., June 1, 2002; 21(3): 250 - 258. [Abstract] [Full Text] [PDF]

				M. Schwarz, D. L. Davis, B. R. Vick, and D. W. Russell Genetic analysis of intestinal cholesterol absorption in inbred mice J. Lipid Res., November 1, 2001; 42(11): 1801 - 1811. [Abstract] [Full Text] [PDF]

				D. Q-H. Wang, B. Paigen, and M. C. Carey Genetic factors at the enterocyte level account for variations in intestinal cholesterol absorption efficiency among inbred strains of mice J. Lipid Res., November 1, 2001; 42(11): 1820 - 1830. [Abstract] [Full Text] [PDF]

				M. Souidi, M. Combettes-Souverain, F. Milliat, E. R. Eckhardt, O. Audas, S. Dubrac, M. Parquet, J. Férézou, and C. Lutton Hamsters Predisposed to Sucrose-Induced Cholesterol Gallstones (LPN Strain) Are More Resistant to Excess Dietary Cholesterol than Hamsters That Are Not Sensitive to Cholelithiasis Induction J. Nutr., June 1, 2001; 131(6): 1803 - 1811. [Abstract] [Full Text]

				G. Beaumier-Gallon, C. Dubois, M. Senft, M.-F. Vergnes, A.-M. Pauli, H. Portugal, and D. Lairon Dietary cholesterol is secreted in intestinally derived chylomicrons during several subsequent postprandial phases in healthy humans Am. J. Clinical Nutrition, May 1, 2001; 73(5): 870 - 877. [Abstract] [Full Text] [PDF]

				R. M Weggemans, P. L Zock, and M. B Katan Dietary cholesterol from eggs increases the ratio of total cholesterol to high-density lipoprotein cholesterol in humans: a meta-analysis Am. J. Clinical Nutrition, May 1, 2001; 73(5): 885 - 891. [Abstract] [Full Text] [PDF]

				L. B. Nguyen, S. Shefer, G. Salen, G. S. Tint, F. Ruiz, and J. Bullock Mechanisms for cholesterol homeostasis in rat jejunal mucosa: effects of cholesterol, sitosterol, and lovastatin J. Lipid Res., February 1, 2001; 42(2): 195 - 200. [Abstract] [Full Text]

				R. E. Ostlund , Jr., M. S. Bosner, and W. F. Stenson Cholesterol absorption efficiency declines at moderate dietary doses in normal human subjects J. Lipid Res., August 1, 1999; 40(8): 1453 - 1458. [Abstract] [Full Text]