|
 |
|
|||||||
|
|||||||||
Correspondence to:
Keith K. Stanley.
We have examined the expression of caveolin in MDCK cells under conditions that vary cellular cholesterol concentration. Caveolin mRNA levels dropped to one-sixth of control levels after treatment with simvastatin, an inhibitor of cholesterol synthesis, or ß-trimethyl cyclodextrin (CD), a cholesterol sequestering drug. Both simvastatin and CD treatment decreased total cellular cholesterol levels to about 50% of control values. The potent activator of the sterol regulatory element, 25-hydroxycholesterol, showed no direct regulation of caveolin mRNA levels. Caveolin protein concentration was also decreased to 50% of control values in cholesterol-depleted cells, giving rise to a severe attenuation of caveolin expression detected by indirect immunofluorescence labeling. Quantitative electron microscopy showed a total loss of morphologically recognizable invaginated caveolae after these cholesterol depletion treatments. When the number of invaginated caveolae per cell was expressed as a function of the cellular cholesterol content, a threshold phenomenon was observed, suggesting that caveolae only form when the steady state cellular cholesterol is above 50% of control values.
These findings indicate that caveolins, and caveolae, may play an important part in cellular cholesterol homeostasis. — Hail- stones, D., L. S. Sleer, R. G. Parton, and K. K. Stanley. Regulation of caveolin and caveolae by cholesterol in MDCK cells. J. Lipid Res. 1998. 39: 369–379.
Supplementary key words:
caveolae, caveolin, cyclodextrin, 25-hydroxycholesterol, simvastatin
Copyright © 1998 by Lipid Research, Inc.
Original Article
Regulation of caveolin and caveolae by cholesterol in MDCK cells
Deborah Hailstonesa,
Leanne S. Sleera,
Robert G. Partonb, and
Keith K. Stanleya
a The Heart Research Institute, 145 Missenden Road, Camperdown NSW 2050, Sydney, Australia
b Centre for Microscopy and Microanalysis, Department of Physiology and Pharmacology, Centre for Molecular and Cellular Biology, University of Queensland, QLD 4092, Brisbane, Australia
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  Z. H. Huang, D. Gu, and T. Mazzone Role of adipocyte-derived apoE in modulating adipocyte size, lipid metabolism, and gene expression in vivo Am J Physiol Endocrinol Metab, May 1, 2009; 296(5): E1110 - E1119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hahn-Obercyger, L. Graeve, and Z. Madar A high-cholesterol diet increases the association between caveolae and insulin receptors in rat liver J. Lipid Res., January 1, 2009; 50(1): 98 - 107. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Liu and P. F. Pilch A Critical Role of Cavin (Polymerase I and Transcript Release Factor) in Caveolae Formation and Organization J. Biol. Chem., February 15, 2008; 283(7): 4314 - 4322. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Shmuel, E. Nodel-Berner, T. Hyman, A. Rouvinski, and Y. Altschuler Caveolin 2 Regulates Endocytosis and Trafficking of the M1 Muscarinic Receptor in MDCK Epithelial Cells Mol. Biol. Cell, May 1, 2007; 18(5): 1570 - 1585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-H. Sun, D. C. Flynn, V. Castranova, L. L. Millecchia, A. R. Beardsley, and J. Liu Identification of a Novel Domain at the N Terminus of Caveolin-1 That Controls Rear Polarization of the Protein and Caveolae Formation J. Biol. Chem., March 9, 2007; 282(10): 7232 - 7241. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. H. Huang, C. A. Reardon, and T. Mazzone Endogenous ApoE Expression Modulates Adipocyte Triglyceride Content and Turnover Diabetes, December 1, 2006; 55(12): 3394 - 3402. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Gosens, G. L. Stelmack, G. Dueck, K. D. McNeill, A. Yamasaki, W. T. Gerthoffer, H. Unruh, A. S. Gounni, J. Zaagsma, and A. J Halayko Role of caveolin-1 in p42/p44 MAP kinase activation and proliferation of human airway smooth muscle Am J Physiol Lung Cell Mol Physiol, September 1, 2006; 291(3): L523 - L534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Idkowiak-Baldys, K. P. Becker, K. Kitatani, and Y. A. Hannun Dynamic Sequestration of the Recycling Compartment by Classical Protein Kinase C J. Biol. Chem., August 4, 2006; 281(31): 22321 - 22331. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. G. Frank, M. W.-C. Cheung, S. Pavlides, G. Llaverias, D. S. Park, and M. P. Lisanti Caveolin-1 and regulation of cellular cholesterol homeostasis Am J Physiol Heart Circ Physiol, August 1, 2006; 291(2): H677 - H686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Frank and M. P. Lisanti Defining lipid raft structure and function with proximity imaging Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2165 - H2166. [Full Text] [PDF]
|
|
|
|
|
|
J. G. Kay, R. Z. Murray, J. K. Pagan, and J. L. Stow Cytokine Secretion via Cholesterol-rich Lipid Raft-associated SNAREs at the Phagocytic Cup J. Biol. Chem., April 28, 2006; 281(17): 11949 - 11954. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Parr, S. M. Storey, D. M. Mitchell, A. L. McIntosh, M. Zhou, K. D. Mir, and J. M. Ball The Rotavirus Enterotoxin NSP4 Directly Interacts with the Caveolar Structural Protein Caveolin-1 J. Virol., March 15, 2006; 80(6): 2842 - 2854. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Mehta and A. B. Malik Signaling Mechanisms Regulating Endothelial Permeability Physiol Rev, January 1, 2006; 86(1): 279 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. C. Matthews, M. J. Taggart, and M. Westwood Effect of Cholesterol Depletion on Mitogenesis and Survival: The Role of Caveolar and Noncaveolar Domains in Insulin-Like Growth Factor-Mediated Cellular Function Endocrinology, December 1, 2005; 146(12): 5463 - 5473. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Park, M. Suh, B. Thomson, A. B.R. Thomson, K. S. Ramanujam, and M. T. Clinin Dietary ganglioside decreases cholesterol content, caveolin expression and inflammatory mediators in rat intestinal microdomains Glycobiology, October 1, 2005; 15(10): 935 - 942. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Wang and A. A. Abdel-Rahman Effect of chronic ethanol administration on hepatic eNOS activity and its association with caveolin-1 and calmodulin in female rats Am J Physiol Gastrointest Liver Physiol, September 1, 2005; 289(3): G579 - G585. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Y. Breusegem, N. Halaihel, M. Inoue, H. Zajicek, E. Lederer, N. P. Barry, V. Sorribas, and M. Levi Acute and chronic changes in cholesterol modulate Na-Pi cotransport activity in OK cells Am J Physiol Renal Physiol, July 1, 2005; 289(1): F154 - F165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Maxwell, M. E. Cleasby, A. Harding, A. Stark, G. J. Cooney, and G. E. O. Muscat Nur77 Regulates Lipolysis in Skeletal Muscle Cells: EVIDENCE FOR CROSS-TALK BETWEEN THE {beta}-ADRENERGIC AND AN ORPHAN NUCLEAR HORMONE RECEPTOR PATHWAY J. Biol. Chem., April 1, 2005; 280(13): 12573 - 12584. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pol, S. Martin, M. A. Fernandez, M. Ingelmo-Torres, C. Ferguson, C. Enrich, and R. G. Parton Cholesterol and Fatty Acids Regulate Dynamic Caveolin Trafficking through the Golgi Complex and between the Cell Surface and Lipid Bodies Mol. Biol. Cell, April 1, 2005; 16(4): 2091 - 2105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-L. Wang, D. Ye, T. E. Peterson, S. Cao, V. H. Shah, Z. S. Katusic, G. C. Sieck, and H.-C. Lee Caveolae Targeting and Regulation of Large Conductance Ca2+-activated K+ Channels in Vascular Endothelial Cells J. Biol. Chem., March 25, 2005; 280(12): 11656 - 11664. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Pietiainen, V. Marjomaki, P. Upla, L. Pelkmans, A. Helenius, and T. Hyypia Echovirus 1 Endocytosis into Caveosomes Requires Lipid Rafts, Dynamin II, and Signaling Events Mol. Biol. Cell, November 1, 2004; 15(11): 4911 - 4925. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Podar, R. Shringarpure, Y.-T. Tai, M. Simoncini, M. Sattler, K. Ishitsuka, P. G. Richardson, T. Hideshima, D. Chauhan, and K. C. Anderson Caveolin-1 Is Required for Vascular Endothelial Growth Factor-Triggered Multiple Myeloma Cell Migration and Is Targeted by Bortezomib Cancer Res., October 15, 2004; 64(20): 7500 - 7506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Lau, S. J. Nixon, R. G. Parton, and G. E. O. Muscat ROR{alpha} Regulates the Expression of Genes Involved in Lipid Homeostasis in Skeletal Muscle Cells: CAVEOLIN-3 AND CPT-1 ARE DIRECT TARGETS OF ROR J. Biol. Chem., August 27, 2004; 279(35): 36828 - 36840. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H. Massol, J. E. Larsen, Y. Fujinaga, W. I. Lencer, and T. Kirchhausen Cholera Toxin Toxicity Does Not Require Functional Arf6- and Dynamin-dependent Endocytic Pathways Mol. Biol. Cell, August 1, 2004; 15(8): 3631 - 3641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. E. Daniel, G. Bodie, M. Mannarino, G. Boddy, and W.-J. Cho Changes in membrane cholesterol affect caveolin-1 localization and ICC-pacing in mouse jejunum Am J Physiol Gastrointest Liver Physiol, July 1, 2004; 287(1): G202 - G210. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Buk, M. Waibel, C. Braig, A. S. Martens, P. C. Heinrich, and L. Graeve Polarity and lipid raft association of the components of the ciliary neurotrophic factor receptor complex in Madin-Darby canine kidney cells J. Cell Sci., April 15, 2004; 117(10): 2063 - 2075. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Fu, A. Hoang, G. Escher, R. G. Parton, Z. Krozowski, and D. Sviridov Expression of Caveolin-1 Enhances Cholesterol Efflux in Hepatic Cells J. Biol. Chem., April 2, 2004; 279(14): 14140 - 14146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. V. Burgos, C. Klattenhoff, E. de la Fuente, A. Rigotti, and A. Gonzalez Cholesterol depletion induces PKA-mediated basolateral-to-apical transcytosis of the scavenger receptor class B type I in MDCK cells PNAS, March 16, 2004; 101(11): 3845 - 3850. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Pouvreau, C. Berthier, S. Blaineau, J. Amsellem, R. Coronado, and C. Strube Membrane cholesterol modulates dihydropyridine receptor function in mice fetal skeletal muscle cells J. Physiol., March 1, 2004; 555(2): 365 - 381. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Hnasko and M. P. Lisanti The Biology of Caveolae: Lessons from Caveolin Knockout Mice and Implications for Human Disease Mol. Interv., December 1, 2003; 3(8): 445 - 464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. B. Chauhan Membrane dynamics, cholesterol homeostasis, and Alzheimer's disease J. Lipid Res., November 1, 2003; 44(11): 2019 - 2029. [Abstract] [Full Text]
|
|
|
|
|
|
P. Gargalovic and L. Dory Cellular apoptosis is associated with increased caveolin-1 expression in macrophages J. Lipid Res., September 1, 2003; 44(9): 1622 - 1632. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. L. TUMA and A. L. HUBBARD Transcytosis: Crossing Cellular Barriers Physiol Rev, July 1, 2003; 83(3): 871 - 932. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. R. Nabi and P. U. Le Caveolae/raft-dependent endocytosis J. Cell Biol., May 26, 2003; 161(4): 673 - 677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Huo, X. Guo, S. Hong, M. Jiang, X. Liu, and K. Liao Lipid Rafts/Caveolae Are Essential for Insulin-like Growth Factor-1 Receptor Signaling during 3T3-L1 Preadipocyte Differentiation Induction J. Biol. Chem., March 21, 2003; 278(13): 11561 - 11569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Podar, Y.-T. Tai, C. E. Cole, T. Hideshima, M. Sattler, A. Hamblin, N. Mitsiades, R. L. Schlossman, F. E. Davies, G. J. Morgan, et al. Essential Role of Caveolae in Interleukin-6- and Insulin-like Growth Factor I-triggered Akt-1-mediated Survival of Multiple Myeloma Cells J. Biol. Chem., February 14, 2003; 278(8): 5794 - 5801. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hua, S. Munk, and C. I. Whiteside Endothelin-1 activates mesangial cell ERK1/2 via EGF-receptor transactivation and caveolin-1 interaction Am J Physiol Renal Physiol, February 1, 2003; 284(2): F303 - F312. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Gargalovic and L. Dory Caveolins and macrophage lipid metabolism J. Lipid Res., January 1, 2003; 44(1): 11 - 21. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ring, J. Pohl, A. Volkl, and W. Stremmel Evidence for vesicles that mediate long-chain fatty acid uptake by human microvascular endothelial cells J. Lipid Res., December 1, 2002; 43(12): 2095 - 2104. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Razani, S. E. Woodman, and M. P. Lisanti Caveolae: From Cell Biology to Animal Physiology Pharmacol. Rev., September 1, 2002; 54(3): 431 - 467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Pohl, A. Ring, and W. Stremmel Uptake of long-chain fatty acids in HepG2 cells involves caveolae: analysis of a novel pathway J. Lipid Res., August 1, 2002; 43(9): 1390 - 1399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Xu, S. Takeda, T. Nakata, Y. Noda, Y. Tanaka, and N. Hirokawa Role of KIFC3 motor protein in Golgi positioning and integration J. Cell Biol., July 22, 2002; 158(2): 293 - 303. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Grimmer, B. van Deurs, and K. Sandvig Membrane ruffling and macropinocytosis in A431 cells require cholesterol J. Cell Sci., July 15, 2002; 115(14): 2953 - 2962. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Goligorsky, H. Li, S. Brodsky, and J. Chen Relationships between caveolae and eNOS: everything in proximity and the proximity of everything Am J Physiol Renal Physiol, July 1, 2002; 283(1): F1 - F10. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Roepstorff, P. Thomsen, K. Sandvig, and B. van Deurs Sequestration of Epidermal Growth Factor Receptors in Non-caveolar Lipid Rafts Inhibits Ligand Binding J. Biol. Chem., May 17, 2002; 277(21): 18954 - 18960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Carozzi, S. Roy, I. C. Morrow, A. Pol, B. Wyse, J. Clyde-Smith, I. A. Prior, S. J. Nixon, J. F. Hancock, and R. G. Parton Inhibition of Lipid Raft-dependent Signaling by a Dystrophy-associated Mutant of Caveolin-3 J. Biol. Chem., May 10, 2002; 277(20): 17944 - 17949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Empig and M. A. Goldsmith Association of the Caveola Vesicular System with Cellular Entry by Filoviruses J. Virol., April 16, 2002; 76(10): 5266 - 5270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. S. Garver, K. Krishnan, J. R. Gallagos, M. Michikawa, G. A. Francis, and R. A. Heidenreich Niemann-Pick C1 protein regulates cholesterol transport to the trans-Golgi network and plasma membrane caveolae J. Lipid Res., April 1, 2002; 43(4): 579 - 589. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Mobius, Y. Ohno-Iwashita, E. G. van Donselaar, V. M.J. Oorschot, Y. Shimada, T. Fujimoto, H. F.G. Heijnen, H. J. Geuze, and J. W. Slot Immunoelectron Microscopic Localization of Cholesterol Using Biotinylated and Non-cytolytic Perfringolysin O J. Histochem. Cytochem., January 1, 2002; 50(1): 43 - 56. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Bickel Lipid rafts and insulin signaling Am J Physiol Endocrinol Metab, January 1, 2002; 282(1): E1 - E10. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Thomsen, K. Roepstorff, M. Stahlhut, and B. van Deurs Caveolae Are Highly Immobile Plasma Membrane Microdomains, Which Are not Involved in Constitutive Endocytic Trafficking Mol. Biol. Cell, January 1, 2002; 13(1): 238 - 250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. McCabe and L. G. Berthiaume N-Terminal Protein Acylation Confers Localization to Cholesterol, Sphingolipid-enriched Membranes But Not to Lipid Rafts/Caveolae Mol. Biol. Cell, November 1, 2001; 12(11): 3601 - 3617. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Jayachandran, T. Hayashi, D. Sumi, A. Iguchi, and V. M. Miller Temporal effects of 17{beta}-estradiol on caveolin-1 mRNA and protein in bovine aortic endothelial cells Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1327 - H1333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Shah, S. Cao, H. Hendrickson, J. Yao, and Z. S. Katusic Regulation of hepatic eNOS by caveolin and calmodulin after bile duct ligation in rats Am J Physiol Gastrointest Liver Physiol, June 1, 2001; 280(6): G1209 - G1216. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Alfsen, P. Iniguez, E. Bouguyon, and M. Bomsel Secretory IgA Specific for a Conserved Epitope on gp41 Envelope Glycoprotein Inhibits Epithelial Transcytosis of HIV-1 J. Immunol., May 15, 2001; 166(10): 6257 - 6265. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. G. Frank, F. Galbiati, D. Volonte, B. Razani, D. E. Cohen, Y. L. Marcel, and M. P. Lisanti Influence of caveolin-1 on cellular cholesterol efflux mediated by high-density lipoproteins Am J Physiol Cell Physiol, May 1, 2001; 280(5): C1204 - C1214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Grimmer, T.-G. Iversen, B. van Deurs, and K. Sandvig Endosome to Golgi Transport of Ricin Is Regulated by Cholesterol Mol. Biol. Cell, December 1, 2000; 11(12): 4205 - 4216. [Abstract] [Full Text]
|
|
|
|
 |
|
 Y. Zhu, H.-L. Liao, N. Wang, Y. Yuan, K.-S. Ma, L. Verna, and M. B. Stemerman Lipoprotein Promotes Caveolin-1 and Ras Translocation to Caveolae : Role of Cholesterol in Endothelial Signaling Arterioscler Thromb Vasc Biol, November 1, 2000; 20(11): 2465 - 2470. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. S. Garver, R. A. Heidenreich, R. P. Erickson, M. A. Thomas, and J. M. Wilson Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments J. Lipid Res., May 1, 2000; 41(5): 673 - 687. [Abstract] [Full Text]
|
|
|
|
|
|
P. Verkade, T. Harder, F. Lafont, and K. Simons Induction of Caveolae in the Apical Plasma Membrane of Madin-Darby Canine Kidney Cells J. Cell Biol., February 21, 2000; 148(4): 727 - 740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. H. Hansen, L.-L. Niels-Christiansen, E. Thorsen, L. Immerdal, and E. M. Danielsen Cholesterol Depletion of Enterocytes. EFFECT ON THE GOLGI COMPLEX AND APICAL MEMBRANE TRAFFICKING J. Biol. Chem., February 18, 2000; 275(7): 5136 - 5142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Machleidt, W.-P. Li, P. Liu, and R. G.W. Anderson Multiple Domains in Caveolin-1 Control Its Intracellular Traffic J. Cell Biol., January 10, 2000; 148(1): 17 - 28. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T Fujimoto, H Kogo, R Nomura, and T Une Isoforms of caveolin-1 and caveolar structure J. Cell Sci., January 10, 2000; 113(19): 3509 - 3517. [Abstract] [PDF]
|
|
|
|
|
|
P. Le, N Benlimame, A Lagana, A Raz, and I. Nabi Clathrin-mediated endocytosis and recycling of autocrine motility factor receptor to fibronectin fibrils is a limiting factor for NIH-3T3 cell motility J. Cell Sci., January 9, 2000; 113(18): 3227 - 3240. [Abstract] [PDF]
|
|
|
|
|
|
G. J. Schroepfer Jr. Oxysterols: Modulators of Cholesterol Metabolism and Other Processes Physiol Rev, January 1, 2000; 80(1): 361 - 554. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Lange, J. Ye, M. Rigney, and T. L. Steck Regulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol J. Lipid Res., December 1, 1999; 40(12): 2264 - 2270. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Smart, G. A. Graf, M. A. McNiven, W. C. Sessa, J. A. Engelman, P. E. Scherer, T. Okamoto, and M. P. Lisanti Caveolins, Liquid-Ordered Domains, and Signal Transduction Mol. Cell. Biol., November 1, 1999; 19(11): 7289 - 7304. [Full Text] [PDF]
|
|
|
|
|
|
A. L. Munn, A. Heese-Peck, B. J. Stevenson, H. Pichler, and H. Riezman Specific Sterols Required for the Internalization Step of Endocytosis in Yeast Mol. Biol. Cell, November 1, 1999; 10(11): 3943 - 3957. [Abstract] [Full Text]
|
|
|
|
|
|
R. Luetterforst, E. Stang, N. Zorzi, A. Carozzi, M. Way, and R. G. Parton Molecular Characterization of Caveolin Association with the Golgi Complex: Identification of a Cis-Golgi Targeting Domain in the Caveolin Molecule J. Cell Biol., June 28, 1999; 145(7): 1443 - 1459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. H. Rothblat, M. de la Llera-Moya, V. Atger, G. Kellner-Weibel, D. L. Williams, and M. C. Phillips Cell cholesterol efflux: integration of old and new observations provides new insights J. Lipid Res., May 1, 1999; 40(5): 781 - 796. [Abstract] [Full Text]
|
|
|
|
|
|
S. K. Rodal, G. Skretting, O. Garred, F. Vilhardt, B. van Deurs, and K. Sandvig Extraction of Cholesterol with Methyl-beta -Cyclodextrin Perturbs Formation of Clathrin-coated Endocytic Vesicles Mol. Biol. Cell, April 1, 1999; 10(4): 961 - 974. [Abstract] [Full Text]
|
|
|
|
|
|
P. Scheiffele, A. Rietveld, T. Wilk, and K. Simons Influenza Viruses Select Ordered Lipid Domains during Budding from the Plasma Membrane J. Biol. Chem., January 22, 1999; 274(4): 2038 - 2044. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. W. Shaul and R. G. W. Anderson Role of plasmalemmal caveolae in signal transduction Am J Physiol Lung Cell Mol Physiol, November 1, 1998; 275(5): L843 - L851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. J. Field, E. Born, S. Murthy, and S. N. Mathur Caveolin is present in intestinal cells: role in cholesterol trafficking? J. Lipid Res., October 1, 1998; 39(10): 1938 - 1950. [Abstract] [Full Text]
|
|
|
|
|
|
F. Lafont, S. Lecat, P. Verkade, and K. Simons Annexin XIIIb Associates with Lipid Microdomains to Function in Apical Delivery J. Cell Biol., September 21, 1998; 142(6): 1413 - 1427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Parpal, M. Karlsson, H. Thorn, and P. Stralfors Cholesterol Depletion Disrupts Caveolae and Insulin Receptor Signaling for Metabolic Control via Insulin Receptor Substrate-1, but Not for Mitogen-activated Protein Kinase Control J. Biol. Chem., March 23, 2001; 276(13): 9670 - 9678. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. E. Karpen, J. T. Bukowski, T. Hughes, J.-P. Gratton, W. C. Sessa, and M. R. Gailani The Sonic Hedgehog Receptor Patched Associates with Caveolin-1 in Cholesterol-rich Microdomains of the Plasma Membrane J. Biol. Chem., June 1, 2001; 276(22): 19503 - 19511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Gargalovic and L. Dory Caveolin-1 and Caveolin-2 Expression in Mouse Macrophages. HIGH DENSITY LIPOPROTEIN 3-STIMULATED SECRETION AND A LACK OF SIGNIFICANT SUBCELLULAR CO-LOCALIZATION J. Biol. Chem., July 6, 2001; 276(28): 26164 - 26170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Abrami, M. Fivaz, T. Kobayashi, T. Kinoshita, R. G. Parton, and F. G. van der Goot Cross-talk between Caveolae and Glycosylphosphatidylinositol-rich Domains J. Biol. Chem., August 10, 2001; 276(33): 30729 - 30736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Razani, J. A. Engelman, X. B. Wang, W. Schubert, X. L. Zhang, C. B. Marks, F. Macaluso, R. G. Russell, M. Li, R. G. Pestell, et al. Caveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities J. Biol. Chem., October 5, 2001; 276(41): 38121 - 38138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. T. Watson, S. Shigematsu, S.-H. Chiang, S. Mora, M. Kanzaki, I. G. Macara, A. R. Saltiel, and J. E. Pessin Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation J. Cell Biol., August 20, 2001; 154(4): 829 - 840. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |