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Correspondence to:
Miguel A. Vega.
Mouse and hamster SR-BI glycoproteins and their putative human counterpart CLA-I are so far the only scavenger receptors known to bind both native and modified lipoproteins. CD36, a multigland glycoprotein structurally related to SR-BI and CLA-1, has been reported to bind oxidized low density lipoprotein (OxLDL) and acetylated LDL (AcLDL). In this report, we have studied the ability of CD36 to bind native lipoproteins. By transient expression of human CD36 in mammalian and insect cells, we demonstrate that CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, VLDL, and, as previously reported, for OxLDL and AcLDL. The specificity of these interactions is supported by the dose-dependent inhibitory effect of a monoclonal antibody against CD36. Furthermore, at least for HDL, binding to CD36 does not require the presence of apoE.
These findings, together with preferential expression of CD36 in tissues performing very active fatty acid metabolism (skeletal muscle, heart, mammary epithelium, and adipose tissue) and its involvement in foam cell formation (macrophages), suggest that binding of lipoproteins to CD36 might contribute to the regulation of lipid metabolism, and to the pathogenesis of atherosclerosis.—Calvo, D., D. Gómez-Coronado, Y. Suárez, M. A. Lasunción, and M. A. Vega. Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL. J. Lipid Res. 1998. 39: 777–788.
Supplementary key words:
scavenger receptor, cholesterol, fatty acids, atherosclerosis
Copyright © 1998 by Lipid Research, Inc.
Original Article
Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL
Dominica Calvoa,
Diego Gómez-Coronadob,
Yajaira Suárezb,
Miguel A. Lasunciónb, and
Miguel A. Vegac
a Hospital de la Princesa, Madrid, Spain
b Servicio de Bioquímica-Investigación, Hospital Ramón y Cajal, Madrid
c Instituto de Parasitología y Biomedicina López-Neyra, C.S.I.C., Granada, Spain
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X. Gu, B. Trigatti, S. Xu, S. Acton, J. Babitt, and M. Krieger The Efficient Cellular Uptake of High Density Lipoprotein Lipids via Scavenger Receptor Class B Type I Requires Not Only Receptor-mediated Surface Binding but Also Receptor-specific Lipid Transfer Mediated by Its Extracellular Domain J. Biol. Chem., October 9, 1998; 273(41): 26338 - 26348. [Abstract] [Full Text] [PDF]
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N. Ohgami, R. Nagai, M. Ikemoto, H. Arai, A. Kuniyasu, S. Horiuchi, and H. Nakayama CD36, a Member of the Class B Scavenger Receptor Family, as a Receptor for Advanced Glycation End Products J. Biol. Chem., January 26, 2001; 276(5): 3195 - 3202. [Abstract] [Full Text] [PDF]
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