Rapid Communication

Body mass index and hepatic lipase gene (LIPC) polymorphism jointly influence postheparin plasma hepatic lipase activity

Correspondence to: Jonathan C. Cohen.

The -514 polymorphism in the hepatic lipase gene (LIPC) is associated with decreased hepatic lipase activity. In the present study, the interaction between body mass index (BMI), the -514 polymorphism, and hepatic lipase activity was examined in 118 white men and in 51 African American men. BMI was significantly positively correlated with hepatic lipase activity in both populations. BMI was similar in men with genetic differences in hepatic lipase activity, indicating that high hepatic lipase activity did not cause increased BMI. The data therefore suggest that high BMI leads to increased hepatic lipase activity. The actions of BMI and the -514 polymorphism on hepatic lipase activity appear to be additive and independent, rather than synergistic.

This finding indicates that hepatic lipase activity is a multifactorial trait, determined in part by polymorphism within the LIPC gene as well as by factors that influence BMI.—Nie, L., J. Wang, L. T. Clark, A. Tang, G. L. Vega, S. M. Grundy, and J. C. Cohen. Body mass index and hepatic lipase gene (LIPC) polymorphism jointly influence postheparin plasma hepatic lipase activity. J. Lipid Res. 1998. 39: 1127–1130.

Supplementary key words: adiposity, LIPC, -514 polymorphism

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				N. Grarup, C. H. Andreasen, M. K. Andersen, A. Albrechtsen, A. Sandbaek, T. Lauritzen, K. Borch-Johnsen, T. Jorgensen, O. Schmitz, T. Hansen, et al. The -250G>A Promoter Variant in Hepatic Lipase Associates with Elevated Fasting Serum High-Density Lipoprotein Cholesterol Modulated by Interaction with Physical Activity in a Study of 16,156 Danish Subjects J. Clin. Endocrinol. Metab., June 1, 2008; 93(6): 2294 - 2299. [Abstract] [Full Text] [PDF]

				G. F. Lewis and D. J. Rader New Insights Into the Regulation of HDL Metabolism and Reverse Cholesterol Transport Circ. Res., June 24, 2005; 96(12): 1221 - 1232. [Abstract] [Full Text] [PDF]

				C. Zhang, R. Lopez-Ridaura, E. B Rimm, N. Rifai, D. J Hunter, and F. B Hu Interactions between the -514C->T polymorphism of the hepatic lipase gene and lifestyle factors in relation to HDL concentrations among US diabetic men Am. J. Clinical Nutrition, June 1, 2005; 81(6): 1429 - 1435. [Abstract] [Full Text] [PDF]

				A. Isaacs, F. A. Sayed-Tabatabaei, O. T. Njajou, J. C. M. Witteman, and C. M. van Duijn The -514 C->T Hepatic Lipase Promoter Region Polymorphism and Plasma Lipids: A Meta-Analysis J. Clin. Endocrinol. Metab., August 1, 2004; 89(8): 3858 - 3863. [Abstract] [Full Text] [PDF]

				M. C. Carr, J. D. Brunzell, and S. S. Deeb Ethnic differences in hepatic lipase and HDL in Japanese, black, and white Americans: role of central obesity and LIPC polymorphisms J. Lipid Res., March 1, 2004; 45(3): 466 - 473. [Abstract] [Full Text] [PDF]

				J. E. Hokanson, M. I. Kamboh, S. Scarboro, R. H. Eckel, and R. F. Hamman Effects of the Hepatic Lipase Gene and Physical Activity on Coronary Heart Disease Risk Am. J. Epidemiol., November 1, 2003; 158(9): 836 - 843. [Abstract] [Full Text] [PDF]

				I. I.L. Berk-Planken, N. Hoogerbrugge, R. P. Stolk, A. H. Bootsma, and H. Jansen Atorvastatin Dose-Dependently Decreases Hepatic Lipase Activity in Type 2 Diabetes: Effect of sex and the LIPC promoter variant Diabetes Care, February 1, 2003; 26(2): 427 - 432. [Abstract] [Full Text] [PDF]

				References Circulation, December 17, 2002; 106(25): 3373 - 3421. [Full Text]

				J. Pihlajamaki, L. Karjalainen, P. Karhapaa, I. Vauhkonen, M.-R. Taskinen, S. S. Deeb, and M. Laakso G-250A Substitution in Promoter of Hepatic Lipase Gene Is Associated With Dyslipidemia and Insulin Resistance in Healthy Control Subjects and in Members of Families With Familial Combined Hyperlipidemia Arterioscler. Thromb. Vasc. Biol., July 1, 2000; 20(7): 1789 - 1795. [Abstract] [Full Text] [PDF]

				J. Q. Purnell, S. E. Kahn, J. J. Albers, D. N. Nevin, J. D. Brunzell, and R. S. Schwartz Effect of Weight Loss with Reduction of Intra-Abdominal Fat on Lipid Metabolism in Older Men J. Clin. Endocrinol. Metab., March 1, 2000; 85(3): 977 - 982. [Abstract] [Full Text]

				M. C. Carr, J. E. Hokanson, S. S. Deeb, J. Q. Purnell, E. S. Mitchell, and J. D. Brunzell A Hepatic Lipase Gene Promoter Polymorphism Attenuates the Increase in Hepatic Lipase Activity With Increasing Intra-abdominal Fat in Women Arterioscler. Thromb. Vasc. Biol., November 1, 1999; 19(11): 2701 - 2707. [Abstract] [Full Text] [PDF]

				R. V. Shohet, G. L. Vega, A. Anwar, J. E. Cigarroa, S. M. Grundy, and J. C. Cohen Hepatic Lipase (LIPC) Promoter Polymorphism in Men With Coronary Artery Disease : Allele Frequency and Effects on Hepatic Lipase Activity and Plasma HDL-C Concentrations Arterioscler. Thromb. Vasc. Biol., August 1, 1999; 19(8): 1975 - 1978. [Abstract] [Full Text] [PDF]

				M. Chandalia, N. Abate, A. Garg, J. Stray-Gundersen, and S. M. Grundy Relationship between Generalized and Upper Body Obesity to Insulin Resistance in Asian Indian Men J. Clin. Endocrinol. Metab., July 1, 1999; 84(7): 2329 - 2335. [Abstract] [Full Text]

				T. P. Bersot, G. L. Vega, S. M. Grundy, K. E. Palaoglu, P. Atagündüz, S. Özbayrakçi, O. Gökdemir, and R. W. Mahley Elevated hepatic lipase activity and low levels of high density lipoprotein in a normotriglyceridemic, nonobese Turkish population J. Lipid Res., March 1, 1999; 40(3): 432 - 438. [Abstract] [Full Text]

				G. L. Vega, J. Gao, T. P. Bersot, R. W. Mahley, R. Verstraete, S. M. Grundy, A. White, and J. C. Cohen The -514 polymorphism in the hepatic lipase gene (LIPC) does not influence androgen-mediated stimulation of hepatic lipase activity J. Lipid Res., July 1, 1998; 39(7): 1520 - 1524. [Abstract] [Full Text]