J. Lipid Res. Did you know there is a large type edition? Click here.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vega, G. L.
Right arrow Articles by Cohen, J. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vega, G. L.
Right arrow Articles by Cohen, J. C.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

The Journal of Lipid Research, Vol. 39, 1520-1524, July 1998
Copyright © 1998 by Lipid Research, Inc.

Rapid communication

The -514 polymorphism in the hepatic lipase gene (LIPC) does not influence androgen-mediated stimulation of hepatic lipase activity

Gloria Lena Vegaa, Jimin Gaoa, Thomas P. Bersotb, Robert W. Mahleyb, Richard Verstraetea, Scott M. Grundya, Ann Whitea, and Jonathan C. Cohena
a The Center for Human Nutrition, Departments of Clinical Nutrition and Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235
b The Gladstone Institute of Cardiovascular Disease, The Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, CA 94141

Correspondence to: Jonathan C. Cohen.

The -514T allele of hepatic lipase is associated with increased high density lipoprotein-cholesterol levels in men, but not in women. This observation suggests that the -514C to T polymorphism may diminish the response of hepatic lipase to androgens. To test this hypothesis, five -514T and five -514C homozygous men were treated with the anabolic steroid stanozolol for 6 days. The mean increase in hepatic lipase activity was similar in the two groups (45 ± 10 vs. 51 ± 10 mmol·hr-1 · l-1, P = 0.5). To evaluate the association between the -514 polymorphism and hepatic lipase activity at different physiological androgen concentrations, hepatic lipase genotypes and activities were measured in 44 men and 40 premenopausal women. The effect of the -514T allele on hepatic lipase activity was significant and quantitatively similar in both sexes.

These data indicate that the -514 polymorphism does not influence the response of hepatic lipase activity to androgens, and that the effects of this polymorphism on hepatic lipase activity are independent of androgen action.—Vega, G. L., J. Gao, T. P. Bersot, R. W. Mahley, R. Verstraete, S. M. Grundy, A. White, and J. C. Cohen. The -514 polymorphism in the hepatic lipase gene (LIPC ) does not influence androgen-mediated stimulation of hepatic lipase activity. J. Lipid Res. 1998. 39: 1520–1524.

Supplementary key words: stanozolol, HDL-cholesterol


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 DiabetesHome page
M. Teran-Garcia, N. Santoro, T. Rankinen, J. Bergeron, T. Rice, A. S. Leon, D.C. Rao, J. S. Skinner, R. N. Bergman, J.-P. Despres, et al.
Hepatic Lipase Gene Variant -514C>T Is Associated With Lipoprotein and Insulin Sensitivity Response to Regular Exercise: The HERITAGE Family Study
Diabetes, July 1, 2005; 54(7): 2251 - 2255.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
C. Zhang, R. Lopez-Ridaura, E. B Rimm, N. Rifai, D. J Hunter, and F. B Hu
Interactions between the -514C->T polymorphism of the hepatic lipase gene and lifestyle factors in relation to HDL concentrations among US diabetic men
Am. J. Clinical Nutrition, June 1, 2005; 81(6): 1429 - 1435.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Isaacs, F. A. Sayed-Tabatabaei, O. T. Njajou, J. C. M. Witteman, and C. M. van Duijn
The -514 C->T Hepatic Lipase Promoter Region Polymorphism and Plasma Lipids: A Meta-Analysis
J. Clin. Endocrinol. Metab., August 1, 2004; 89(8): 3858 - 3863.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
R. V. Andersen, H. H. Wittrup, A. Tybjaerg-Hansen, R. Steffensen, P. Schnohr, and B.o. G. Nordestgaard
Hepatic lipase mutations,elevated high-density lipoprotein cholesterol, and increased risk of ischemic heart disease: The Copenhagen City Heart Study
J. Am. Coll. Cardiol., June 4, 2003; 41(11): 1972 - 1982.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
S.-H. H. Juo, Z. Han, J. D. Smith, L. Colangelo, and K. Liu
romoter polymorphisms of hepatic lipase gene influence HDL2 but not HDL3 in African American men: CARDIA study
J. Lipid Res., February 1, 2001; 42(2): 258 - 264.
[Abstract] [Full Text]

Home page
 J. Lipid Res.Home page
S. S. Deeb and R. Peng
The C-514T polymorphism in the human hepatic lipase gene promoter diminishes its activity
J. Lipid Res., January 1, 2000; 41(1): 155 - 158.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 1998 by the American Society for Biochemistry and Molecular Biology.