| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Correspondence to:
Albert W. Girotti.
Lipid peroxidation is a well known example of oxidative damage in cell membranes, lipoproteins, and other lipid-containing structures. Peroxidative modification of unsaturated phospholipids, glycolipids, and cholesterol can occur in reactions triggered by i) free radical species such as oxyl radicals, peroxyl radicals, and hydroxyl radicals derived from iron-mediated reduction of hydrogen peroxide or ii ) non-radical species such as singlet oxygen, ozone, and peroxynitrite generated by the reaction of superoxide with nitric oxide. Lipid hydroperoxides (LOOHs) are prominent non-radical intermediates of lipid peroxidation whose identification can often provide valuable mechanistic information, e.g., whether a primary reaction is mediated by singlet oxygen or oxyradicals. Certain cholesterol-derived hydroperoxides (ChOOHs) have been used very effectively in this regard, both in model systems and cells. Being more polar than parent lipids, LOOHs perturb membrane structure/function and can be deleterious to cells on this basis alone. However, LOOHs can also participate in redox reactions, the nature and magnitude of which often determines whether peroxidative injury is exacerbated or prevented. Exacerbation may reflect iron-catalyzed one-electron reduction of LOOHs, resulting in free radical-mediated chain peroxidation, whereas prevention may reflect selenoperoxidase-catalyzed two-electron reduction of LOOHs to relatively non-toxic alcohols. LOOH partitioning between these two pathways in an oxidatively stressed cell is still poorly understood, but recent cell studies involving various ChOOHs have begun to shed light on this important question. An aspect of related interest that is under intensive investigation is lipid peroxidation/LOOH-mediated stress signaling, which may evoke a variety of cellular responses, ranging from induction of antioxidant enzymes to apoptotic death. Ongoing exploration of these processes will have important bearing on our understanding of disease states associated with peroxidative stress.—Girotti, A. W. Lipid hydroperoxide generation, turnover, and effector action in biological systems. J. Lipid Res. 1998. 39: 1529–1542.
Supplementary key words:
oxidative stress, lipid peroxidation, cholesterol, hydroperoxides, membranes, lipoproteins, iron, selenoperoxidases, signal transduction, apoptosis
Copyright © 1998 by Lipid Research, Inc.
Review
Lipid hydroperoxide generation, turnover, and effector action in biological systems
Albert W. Girottia
a Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226-4801
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  P. Abidi, H. Zhang, S. M Zaidi, W.-J. Shen, S. Leers-Sucheta, Y. Cortez, J. Han, and S. Azhar Oxidative stress-induced inhibition of adrenal steroidogenesis requires participation of p38 mitogen-activated protein kinase signaling pathway J. Endocrinol., July 1, 2008; 198(1): 193 - 207. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Murphy and K. M. Johnson Cholesterol, Reactive Oxygen Species, and the Formation of Biologically Active Mediators J. Biol. Chem., June 6, 2008; 283(23): 15521 - 15525. [Full Text] [PDF]
|
|
|
|
 |
|
 A. B. Gerry and D. S. Leake A moderate reduction in extracellular pH protects macrophages against apoptosis induced by oxidized low density lipoprotein J. Lipid Res., April 1, 2008; 49(4): 782 - 789. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Leekumjorn, Y. Wu, A. K. Sum, and C. Chan Experimental and Computational Studies Investigating Trehalose Protection of HepG2 Cells from Palmitate-Induced Toxicity Biophys. J., April 1, 2008; 94(7): 2869 - 2883. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Perez, F. A. Arenas, G. A. Pradenas, J. M. Sandoval, and C. C. Vasquez Escherichia coli YqhD Exhibits Aldehyde Reductase Activity and Protects from the Harmful Effect of Lipid Peroxidation-derived Aldehydes J. Biol. Chem., March 21, 2008; 283(12): 7346 - 7353. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Franky Dhaval Shah, Shilin Nandubhai Shukla, Pankaj Manubhai Shah, H. R. H. Patel, and Prabhudas Shankerbhai Patel Significance of Alterations in Plasma Lipid Profile Levels in Breast Cancer Integr Cancer Ther, March 1, 2008; 7(1): 33 - 41. [Abstract] [PDF]
|
|
|
|
|
|
R. Soundararajan, A. D. Wishart, H. P. V. Rupasinghe, M. Arcellana-Panlilio, C. M. Nelson, M. Mayne, and G. S. Robertson Quercetin 3-Glucoside Protects Neuroblastoma (SH-SY5Y) Cells in Vitro against Oxidative Damage by Inducing Sterol Regulatory Element-binding Protein-2-mediated Cholesterol Biosynthesis J. Biol. Chem., January 25, 2008; 283(4): 2231 - 2245. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kuehnle, A. Crameri, R. E. Kalin, P. Luciani, S. Benvenuti, A. Peri, F. Ratti, M. Rodolfo, L. Kulic, F. L. Heppner, et al. Prosurvival Effect of DHCR24/Seladin-1 in Acute and Chronic Responses to Oxidative Stress Mol. Cell. Biol., January 15, 2008; 28(2): 539 - 550. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. F. Verit, O. Erel, and N. Celik Serum paraoxonase-1 activity in women with endometriosis and its relationship with the stage of the disease Hum. Reprod., January 1, 2008; 23(1): 100 - 104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Franco, M. I. Panayiotidis, and J. A. Cidlowski Glutathione Depletion Is Necessary for Apoptosis in Lymphoid Cells Independent of Reactive Oxygen Species Formation J. Biol. Chem., October 19, 2007; 282(42): 30452 - 30465. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Ran, H. Liang, Y. Ikeno, W. Qi, T. A. Prolla, L. J. Roberts II, N. Wolf, H. VanRemmen, and A. Richardson Reduction in Glutathione Peroxidase 4 Increases Life Span Through Increased Sensitivity to Apoptosis J. Gerontol. A Biol. Sci. Med. Sci., September 1, 2007; 62(9): 932 - 942. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-Y. Oh, J.-H. Shin, and J.-H. Roe Dual Role of OhrR as a Repressor and an Activator in Response to Organic Hydroperoxides in Streptomyces coelicolor J. Bacteriol., September 1, 2007; 189(17): 6284 - 6292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Liu, S. A. Seibold, C. J. Rieke, I. Song, R. I. Cukier, and W. L. Smith Prostaglandin Endoperoxide H Synthases: PEROXIDASE HYDROPEROXIDE SPECIFICITY AND CYCLOOXYGENASE ACTIVATION J. Biol. Chem., June 22, 2007; 282(25): 18233 - 18244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Coban, J. Popov, M. Burger, D. Vobornik, and L. J. Johnston Transition from Nanodomains to Microdomains Induced by Exposure of Lipid Monolayers to Air Biophys. J., April 15, 2007; 92(8): 2842 - 2853. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Cheng, T. Nguyen, H. Song, and J. Bonanno Hypoxia Protects Human Corneal Endothelium from Tertiary Butyl Hydroperoxide and Paraquat-Induced Cell Death In Vitro Experimental Biology and Medicine, March 1, 2007; 232(3): 445 - 453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kriska, G. K. Marathe, J. C. Schmidt, T. M. McIntyre, and A. W. Girotti Phospholipase Action of Platelet-activating Factor Acetylhydrolase, but Not Paraoxonase-1, on Long Fatty Acyl Chain Phospholipid Hydroperoxides J. Biol. Chem., January 5, 2007; 282(1): 100 - 108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kriska, V. V. Levchenko, W. Korytowski, B. P. Atshaves, F. Schroeder, and A. W. Girotti Intracellular Dissemination of Peroxidative Stress: INTERNALIZATION, TRANSPORT, AND LETHAL TARGETING OF A CHOLESTEROL HYDROPEROXIDE SPECIES BY STEROL CARRIER PROTEIN-2-OVEREXPRESSING HEPATOMA CELLS J. Biol. Chem., August 18, 2006; 281(33): 23643 - 23651. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Seleznev, C. Zhao, X. H. Zhang, K. Song, and Z. A. Ma Calcium-independent Phospholipase A2 Localizes in and Protects Mitochondria during Apoptotic Induction by Staurosporine J. Biol. Chem., August 4, 2006; 281(31): 22275 - 22288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Miyamoto, G. R. Martinez, D. Rettori, O. Augusto, M. H. G. Medeiros, and P. Di Mascio Linoleic acid hydroperoxide reacts with hypochlorous acid, generating peroxyl radical intermediates and singlet molecular oxygen PNAS, January 10, 2006; 103(2): 293 - 298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. F. Jacob and R. P. Mason Lipid Peroxidation Induces Cholesterol Domain Formation in Model Membranes J. Biol. Chem., November 25, 2005; 280(47): 39380 - 39387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Koshiishi, K. Tsuchida, T. Takajo, and M. Komatsu Quantification of lipid alkyl radicals trapped with nitroxyl radical via HPLC with postcolumn thermal decomposition J. Lipid Res., November 1, 2005; 46(11): 2506 - 2513. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lapointe, S. Kimmins, L. A. MacLaren, and J.-F. Bilodeau Estrogen Selectively Up-Regulates the Phospholipid Hydroperoxide Glutathione Peroxidase in the Oviducts Endocrinology, June 1, 2005; 146(6): 2583 - 2592. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Yasuda, M. Yamaya, K. Nakayama, S. Ebihara, T. Sasaki, S. Okinaga, D. Inoue, M. Asada, M. Nemoto, and H. Sasaki Increased Arterial Carboxyhemoglobin Concentrations in Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., June 1, 2005; 171(11): 1246 - 1251. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Xu, L. Chen, L. Leung, T. S. B. Yen, C. Lee, and J. Y. Chan Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia PNAS, March 15, 2005; 102(11): 4120 - 4125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Miketova, K. Kaemingk, M. Hockenberry, A. Pasvogel, J. Hutter, K. Krull, and I. M. Moore Oxidative Changes in Cerebral Spinal Fluid Phosphatidylcholine during Treatment for Acute Lymphoblastic Leukemia Biol Res Nurs, January 1, 2005; 6(3): 187 - 195. [Abstract] [PDF]
|
|
|
|
|
|
Q. Ran, H. Liang, M. Gu, W. Qi, C. A. Walter, L. J. Roberts II, B. Herman, A. Richardson, and H. Van Remmen Transgenic Mice Overexpressing Glutathione Peroxidase 4 Are Protected against Oxidative Stress-induced Apoptosis J. Biol. Chem., December 31, 2004; 279(53): 55137 - 55146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Jaburek, S. Miyamoto, P. Di Mascio, K. D. Garlid, and P. Jezek Hydroperoxy Fatty Acid Cycling Mediated by Mitochondrial Uncoupling Protein UCP2 J. Biol. Chem., December 17, 2004; 279(51): 53097 - 53102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Hansen, Y. Even, and A.-M. Geneviere The {alpha}, {beta}, {gamma}, {partial}-Unsaturated Aldehyde 2-trans-4-trans-Decadienal Disturbs DNA Replication and Mitotic Events in Early Sea Urchin Embryos Toxicol. Sci., September 1, 2004; 81(1): 190 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Sattler, L. U. Gilliland, M. Magallanes-Lundback, M. Pollard, and D. DellaPenna Vitamin E Is Essential for Seed Longevity and for Preventing Lipid Peroxidation during Germination PLANT CELL, June 1, 2004; 16(6): 1419 - 1432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Pritchard Jr., J. Ou, Z. Ou, Y. Shi, J. P. Franciosi, P. Signorino, S. Kaul, C. Ackland-Berglund, K. Witte, S. Holzhauer, et al. Hypoxia-induced acute lung injury in murine models of sickle cell disease Am J Physiol Lung Cell Mol Physiol, April 1, 2004; 286(4): L705 - L714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Kronke, V. N. Bochkov, J. Huber, F. Gruber, S. Bluml, A. Furnkranz, A. Kadl, B. R. Binder, and N. Leitinger Oxidized Phospholipids Induce Expression of Human Heme Oxygenase-1 Involving Activation of cAMP-responsive Element-binding Protein J. Biol. Chem., December 19, 2003; 278(51): 51006 - 51014. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kawai, A. Furuhata, S. Toyokuni, Y. Aratani, and K. Uchida Formation of Acrolein-derived 2'-Deoxyadenosine Adduct in an Iron-induced Carcinogenesis Model J. Biol. Chem., December 12, 2003; 278(50): 50346 - 50354. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Masuelli, R. Bei, P. Sacchetti, I. Scappaticci, P. Francalanci, L. Albonici, A. Coletti, C. Palumbo, M. Minieri, R. Fiaccavento, et al. {beta}-Catenin accumulates in intercalated disks of hypertrophic cardiomyopathic hearts Cardiovasc Res, November 1, 2003; 60(2): 376 - 387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Alic, V. J. Higgins, A. Pichova, M. Breitenbach, and I. W. Dawes Lipid Hydroperoxides Activate the Mitogen-activated Protein Kinase Mpk1p in Saccharomyces cerevisiae J. Biol. Chem., October 24, 2003; 278(43): 41849 - 41855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kawai, A. Saito, N. Shibata, M. Kobayashi, S. Yamada, T. Osawa, and K. Uchida Covalent Binding of Oxidized Cholesteryl Esters to Protein: IMPLICATIONS FOR OXIDATIVE MODIFICATION OF LOW DENSITY LIPOPROTEIN AND ATHEROSCLEROSIS J. Biol. Chem., May 30, 2003; 278(23): 21040 - 21049. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Abstract Section: 11th International Symposium on Trace Elements in Man and Animals Abstracts J. Nutr., May 1, 2003; 133(5): 203E - 282. [Full Text] [PDF]
|
|
|
|
|
|
M. Cnop, J. C. Hannaert, A. Y. Grupping, and D. G. Pipeleers Low Density Lipoprotein Can Cause Death of Islet {beta}-Cells by Its Cellular Uptake and Oxidative Modification Endocrinology, September 1, 2002; 143(9): 3449 - 3453. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yang, R. Sharma, J.-Z. Cheng, M. K. Saini, N. H. Ansari, U. P. Andley, S. Awasthi, and Y. C. Awasthi Protection of HLE B-3 Cells against Hydrogen Peroxide- and Naphthalene-Induced Lipid Peroxidation and Apoptosis by Transfection with hGSTA1 and hGSTA2 Invest. Ophthalmol. Vis. Sci., February 1, 2002; 43(2): 434 - 445. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. PERLEMUTER, A. SABILE, P. LETTERON, G. VONA, A. TOPILCO, Y. CHRETIEN, K. KOIKE, D. PESSAYRE, J. CHAPMAN, G. BARBA, et al. Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral-related steatosis FASEB J, February 1, 2002; 16(2): 185 - 194. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Alic, V. J. Higgins, and I. W. Dawes Identification of a Saccharomyces cerevisiae Gene that Is Required for G1 Arrest in Response to the Lipid Oxidation Product Linoleic Acid Hydroperoxide* Mol. Biol. Cell, June 1, 2001; 12(6): 1801 - 1810. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Bobola, M. S. Berger, R. G. Ellenbogen, T. S. Roberts, J. R. Geyer, and J. R. Silber O6-Methylguanine-DNA Methyltransferase in Pediatric Primary Brain Tumors: Relation to Patient and Tumor Characteristics Clin. Cancer Res., March 1, 2001; 7(3): 613 - 619. [Abstract] [Full Text]
|
|
|
|
|
|
H. H. F. Refsgaard, L. Tsai, and E. R. Stadtman Modifications of proteins by polyunsaturated fatty acid peroxidation products PNAS, January 18, 2000; 97(2): 611 - 616. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Karten, H. Boechzelt, P. M. Abuja, M. Mittelbach, and W. Sattler Macrophage-enhanced formation of cholesteryl ester–core aldehydes during oxidation of low density lipoprotein J. Lipid Res., July 1, 1999; 40(7): 1240 - 1253. [Abstract] [Full Text]
|
|
|
|
|
|
S. Kotamraju, N. Hogg, J. Joseph, L. K. Keefer, and B. Kalyanaraman Inhibition of Oxidized Low-density Lipoprotein-induced Apoptosis in Endothelial Cells by Nitric Oxide. PEROXYL RADICAL SCAVENGING AS AN ANTIAPOPTOTIC MECHANISM J. Biol. Chem., May 11, 2001; 276(20): 17316 - 17323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Tiku, R. Shah, and G. T. Allison Evidence Linking Chondrocyte Lipid Peroxidation to Cartilage Matrix Protein Degradation. POSSIBLE ROLE IN CARTILAGE AGING AND THE PATHOGENESIS OF OSTEOARTHRITIS J. Biol. Chem., June 23, 2000; 275(26): 20069 - 20076. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |
