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The Journal of Lipid Research, Vol. 39, 1589-1593, August 1998
Copyright © 1998 by Lipid Research, Inc.

Original Article

Evidence that the E2-isoprostane, 15-E2t-isoprostane (8-iso-prostaglandin E2) is formed in vivo

Jason D. Morrowa, Jennifer Scruggsa, Yan Chena, William E. Zackerta, and L. Jackson Roberts, IIa
a Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, 506 Medical Research Building 1, Nashville, TN 37232-6602

Correspondence to: Jason D. Morrow.

D2/E2-isoprostanes are prostaglandin D2/E2-like compounds that are produced in vivo as non-enzymatic products of free radical catalyzed peroxidation of arachidonic acid. One E2-isoprostane that should be formed is 15-E2t-isoprostane (8-iso-prostaglandin E2). 15-E2t-isoprostane has been shown to exert potent biological activity but proof that it is formed in vivo is lacking. Evidence is now presented that 15-E2t-isoprostane is formed in vivo by demonstrating that an endogenous E2-isoprostane with a retention time on capillary GC identical with that of 15-E2t-isoprostane co-chromatographs through four high resolving HPLC purification procedures with authentic radiolabeled 15-E2t-isoprostane.—Morrow, J. D., J. Scruggs, Y. Chan, W. E. Zackert, and L. J. Roberts II. Evidence that the E2-isoprostane, 15-E2t-isoprostane (8-iso-prostaglandin E2) is formed in vivo. J. Lipid Res. 1998. 39: 1589–1593.

Supplementary key words: lipid peroxidation, isoeicosanoids, free radicals, eicosanoid


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