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Journal of Lipid Research, Vol. 4, 21-23, January 1963
Copyright © 1963 by Lipid Research, Inc.

Changes in the lipolytic activity of the guinea pig mammary gland at parturition

D. S. Robinson

External Staff of the Medical Research Council Sir William Dunn School of Pathology Oxford, England

During pregnancy, the clearing factor lipase activity of the guinea pig mammary gland remains constant until immediately before parturition. It then increases rapidly until, at parturition, the activity per gland is some 100 times greater than during pregnancy. Activity remains at this high level after parturition. If suckling is prevented at one of the two mammary glands of the guinea pig by tying off the teat, the activity of that gland falls within a few days to a level that is only some 5 times greater than that in the gland during pregnancy. The activity of the suckled gland remains high. The activity of lactating mammary gland tissue is much higher than that of any other tissue studied hitherto.

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