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Journal of Lipid Research, Vol. 4, 57-62, January 1963
Copyright © 1963 by Lipid Research, Inc.

The biochemistry of plasmalogens: II. Hemolytic activity of some plasmalogen derivatives

Eugene L. Gottfried and Maurice M. Rapport

Departments of Medicine and Biochemistry, and the Unit for Research in Aging, Albert Einstein College of Medicine, Yeshiva University, New York 61, N. Y.

A series of lysophosphatides was prepared from the plasmalogens phosphatidal choline and phosphatidal ethanolamine, and their hemolytic activity compared with that of -palmitoyl lysolecithin. The nature of the linkage of the hydrocarbon chain (acyl ester, ,ßbeta;-unsaturated ether, or alkyl ether) did not appreciably affect lytic activity. Unsaturation in the hydrocarbon chain of lysolecithins decreased hemolytic activity considerably; lysocephalins were significantly different in this respect. Sheep erythrocytes were much more sensitive to differences in lysolecithin structure than human or rabbit erythrocytes.

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