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Journal of Lipid Research, Vol. 4, 63-67, January 1963
Copyright © 1963 by Lipid Research, Inc.

A study of the effect of d- and l-triiodothyronine on bile acid excretion of rats

T. H. Lin , R. Rubinstein , and W. L. Holmes

Biochemistry Section, Research and Development Division, Smith Kline & French Laboratories, Philadelphia 1, Pennsylvania

The effect of d- and l-triiodothyronine on bile acid patterns in rats was studied by means of gas-liquid chromatography. Treatment with either d- or l-triiodothyronine caused a relative decrease of cholate and a relative increase of chenodesoxycholate. This is in gross agreement with the results obtained by means of paper chromatography recently reported by Strand. In addition, the present study shows that the above treatment caused a relative increase in a bile acid component suspected to be a metabolite of chenodesoxycholic acid. Preliminary data tend to indicate that intestinal absorption of cholesterol was poorer in d-triiodothyronine-treated rats than in control animals.

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